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Chemical Structure| 35511-15-0 Chemical Structure| 35511-15-0
Chemical Structure| 35511-15-0

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Product Details of Piroxicam Related Compound J

CAS No. :35511-15-0
Formula : C11H11NO5S
M.W : 269.27
SMILES Code : COC(=O)C1=C(C2=C([S](N1C)(=O)=O)C=CC=C2)O
MDL No. :MFCD00071766
InChI Key :NGHIOTWSWSQQNT-UHFFFAOYSA-N
Pubchem ID :54676532

Safety of Piroxicam Related Compound J

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Piroxicam Related Compound J

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35511-15-0 ]

[ 35511-15-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 10167-97-2 ]
  • [ 35511-15-0 ]
  • [ 76066-12-1 ]
  • 2
  • [ 35511-15-0 ]
  • [ 33332-28-4 ]
  • N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
In 5,5-dimethyl-1,3-cyclohexadiene; EXAMPLE 1 N-(6-Chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide A mixture of 9.0 g (33 mmols) of methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide, 4.36 g (33 mmols) of 2-amino-6-chloro-pyrazine and 1200 ml of xylene was refluxed for 24 hours in a nitrogen atmosphere. The methanol formed by the reaction was removed with the aid of a 4 A molecular sieve arranged in a Soxhlet attachment. After cooling and standing overnight, the crystals were filtered off and recrystallized from dioxane. 7.91 g (64percent of theory) of N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide were obtained. Melting point: 278°-279° C. (decomposition). IR (KBr): 1655 cm-1 (CO amide). 1H-NMR ([D6 ]-DMSO): delta=11.70 (br.s,1,OH, exchangeable with CD3 OD; 9.3 (s,1,3'-H); 8.6 (s,1,5'-H); 8.1-7.8 (m,4,5-H to 8H); 2.85 (s,3,N-CH3). MS: M+ 366 m/e. C14 H11 ClN4 O4 S (366.79): Calc.: C--45.84percent; H--3.03percent; N--15.28percent; Cl--9.67percent; S--8.74percent. Found: C--46.08percent; H--3.04percent; N--15.31percent; Cl--9.62percent; S--8.64percent.
 

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