549521-78-0|(3S,6S,10aR)-Ethyl 6-((tert-butoxycarbonyl)amino)-5-oxo-1,2,3,5,6,7,10,10a-octahydropyrrolo[1,2-a]azocine-3-carboxylate| Ambeed

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Quality Control of [ 549521-78-0 ] Purity: 95+% SDS Specification

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Product Details of [ 549521-78-0 ]

CAS No. :	549521-78-0
Formula :	C₁₈H₂₈N₂O₅
M.W :	352.43
SMILES Code :	O=C([C@@H]1CC[C@@](C/C=C\C[C@@H]2NC(OC(C)(C)C)=O)([H])N1C2=O)OCC
MDL No. :	MFCD16038275
InChI Key :	JSPQCKZOXNWHSV-OOBDJQDNSA-N
Pubchem ID :	59828298

Safety of [ 549521-78-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 549521-78-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 549521-78-0 ]

[ 549521-78-0 ] Synthesis Path-Downstream 1~9

1
[ 549521-78-0 ]
[ 1220952-21-5 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen;palladium 10% on activated carbon; In ethanol;	Scheme 1; ι) 4M HCI/dioxane ">CbZ-CI/NaH∞3 CO2Et ") dme HC] CO2H EDCIZHOBtZDIPEAZDCM 5Ref 1 Duggan, H M E , Hitchcock, P B and Young, D W , Org Biomol Chem , 2005, 3, 2287-2295

References: [1]Patent: WO2010/77589,2010,A2 .Location in patent: Page/Page column 37.

2
C₁₆H₂₄N₂O₅ [ No CAS ]
[ 75-03-6 ]
[ 549521-78-0 ]

Yield	Reaction Conditions	Operation in experiment
82%		Compound A2 (32 mg, 0.10 mmol) and KOH (6 mg, 0.10 mmol) were dissolved in THF (2 mL).The suspension was stirred for 1 minute,Ethyl iodide (20 [mu] L, 0.25 mmol) was then added.The mixture was stirred under N2 at room temperature for 12 hours,The resulting residue was dissolved in chloroform.The organic phase was washed with water, dried over anhydrous potassium carbonate,The resulting crude product was purified by column chromatography (cyclohexane / ethyl acetate = 6/1)To give colorless oil B2 (29 mg, 82%).See the chemical equations formula X.

References: [1]Patent: CN106188098,2016,A .Location in patent: Paragraph 0068; 0069; 0070; 0071; 0087; 0088; 0089; 0090.

3
[ 549521-78-0 ]
C₂₁H₃₃N₃O₆ [ No CAS ]