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Chemical Structure| 1404365-04-3 Chemical Structure| 1404365-04-3
Chemical Structure| 1404365-04-3

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Product Details of trans-3-(aminomethyl)cyclobutanol HCl

CAS No. :1404365-04-3
Formula : C5H12ClNO
M.W : 137.61
SMILES Code : O[C@H]1C[C@H](CN)C1.[H]Cl
MDL No. :MFCD22422286

Safety of trans-3-(aminomethyl)cyclobutanol HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of trans-3-(aminomethyl)cyclobutanol HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1404365-04-3 ]

[ 1404365-04-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1414772-61-4 ]
  • [ 1404365-04-3 ]
  • [ 1426928-27-9 ]
YieldReaction ConditionsOperation in experiment
61% At 0-5 C 153 mg (1.11 mmol) <strong>[1404365-04-3]trans-3-(aminomethyl)cyclobutanol hydrochloride</strong> were added to 89 mg (2.23 mmol) sodiumhydride (60% in mineral oil) in 7.5 mL anhydrous DMF. After 5 min of stirring on the ice bath, 150 mg (0.56 mmol) 3-(1 - benzofur-2-yl)-6-chloroimidazo[1 ,2-b]pyridazine were added. The ice bath was removed and it was stirred over night at rt. The reaction mixture was poured into saturated ammonium chloride solution. It was extracted four times with ethyl acetate. The combined organic phases were washed twice with brine, dried over magnesium sulfate and concentrated. The residue was purified by HPLC to yield 114 mg (61 %) product. 1H-NMR (400 MHz, DMSO-d6), delta [ppm] = 2.21 -2.44 (5H), 2.77 (2H), 5.36-5.44 (1 H), 7.01 (1 H), 7.25-7.36 (2H), 7.59 (1 H), 7.62 (1 H), 7.70-7.75 (1 H), 7.71 -7.75 (1 H), 8.11 -8.17 (2H). LC-MS (Method 2): Rt = 0.75 min; MS (ESIpos) m/z = 335 [M+H]+.
  • 2
  • [ 1414772-61-4 ]
  • [ 1404365-04-3 ]
  • [ 1610454-06-2 ]
YieldReaction ConditionsOperation in experiment
4% With potassium carbonate; In butan-1-ol; at 150℃; for 48.0h; 150 mg (0.56 mmol) 3-(1-benzofur-2-yl)-6-chloroimidazo[1 ,2-b]pyridazine, 183.7 mg (1.34 mmol) <strong>[1404365-04-3]trans-3-(aminomethyl)cyclobutanol hydrochloride</strong> (1 :1 ) and 415 mg(3.00 mmol) potassium carbonate in 4.0 mL butan-1-ol were stirred 48 h at 150C. The solvent was removed. The residue was purified by HPLC to yield 7.0 mg (4%). LC-MS (Method 2): Rt = 0.90 min; MS (ESIpos) m/z = 335 [M+H]+. 1H-NMR (400 MHz ,DMSO-d6), delta [ppm]= 1.95-2.05 (2H), 2.10-2.19 (2H), 2.52-2.60 (1H), 3.41-3.48 (2H), 4.28-4.38 (1H), 4.94-5.00 (1H), 6.77-6.82 (1H), 7.21-7.35 (3H), 7.54-7.57 (1H), 7.59-7.65 (1H), 7.67-7.73 (1H), 7.78-7.84 (1H), 7.90-7.95 (1H).
 

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