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Chemical Structure| 33973-59-0 Chemical Structure| 33973-59-0
Chemical Structure| 33973-59-0

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Triacetonamine HCl is a natural product isolated and purified from the senescing flag leaves of the barley varieties Lomerit and Carina and an anticancer chemotherapeutic agent.

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Product Citations

Product Citations

Liu, Andong ; Xia, Haining ; Yang, Hao ; Xu, Xinyi ; Li, Chengjing ; Li, Xiaowen , et al.

Abstract: Hematoporphyrin, a photosensitizer, has substantial potential for photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC). However, the strong hydrophobic interactions between hematoporphyrin molecules cause them to easily aggregate, leading to poor solubility in water and suppression of active photoreactive sites. To address these challenges, a biomimetic synthesis strategy was employed to organically integrate ferroferric oxide (Fe3O4) nanoparticles with hematoporphyrin, resulting in the construction of highly hydrophilic and efficient Fe3O4/Haematoporphyrin@BSA (BMH) nanoparticles. This delivery system effectively improved the solubility, bioavailability, and PDT efficiency of hematoporphyrin. Compared with free hematoporphyrin, the BMH nanoparticles exhibited a smaller average hydrated particle size with excellent dispersion in the PBS solution. Additionally, BMH nanoparticles demonstrated efficient cellular uptake by CAL27 tumor cells in a shorter time frame. PDT experiments on CAL27 tumor cells revealed that under the same light exposure, the BMH nanoparticles resulted in a 58% increase in ROS generation, leading to a 57% increase in cell death compared to the hematoporphyrin group. Notably, the electron spin resonance spectrometer (ESR) results and structural analysis of the protein cages suggested that the organic integration of Fe3O4 nanoparticles with hematoporphyrin enhanced electron transfer and increased free radical production, thereby improving overall PDT efficiency. This study demonstrated that highly biocompatible BMH protein-cage nanoparticles significantly enhanced the therapeutic potential of hematoporphyrin for PDT in OSCC.

Keywords: potential ; PDT ; cell ; hematoporphyrin ; leading ; Fe3O4 ; nanoparticles ; hematoporphyrin ; highly ; efficient ; BMH ; free ; demonstrated ; CAL27 ; tumor ; cells ; increase ; electron ; enhanced

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Product Details of Triacetonamine HCl

CAS No. :33973-59-0
Formula : C9H18ClNO
M.W : 191.70
SMILES Code : O=C1CC(C)(C)NC(C)(C)C1.[H]Cl
MDL No. :MFCD00012768
InChI Key :ZXNWYMNKYXUZGM-UHFFFAOYSA-N
Pubchem ID :94452

Safety of Triacetonamine HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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