CAS No. :	1143-70-0
Formula :	C₁₃H₈O₄
M.W :	228.20
SMILES Code :	O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
Synonyms :	2',7-Dihydroxy-3,4-benzocoumarin; 3,8-Dihydroxy Urolithin
MDL No. :	MFCD20275235
InChI Key :	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Pubchem ID :	5488186

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

HEK293 APP-Swedish cells	30 μM		To evaluate the effect of UA on Aβ42 expression in HEK293 APP-Swedish cells, it was found that UA decreased Aβ42 expression.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
HMC3 human microglia cells	30 μM	48 hours	To evaluate the effect of UA on IL-1β expression in HMC3 cells, it was found that UA significantly reduced IL-1β expression, and this effect was partially dependent on CTSZ.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
SH-SY5Y cells	100 nM	24-48 h	Urolithin A pretreatment significantly inhibited high glucose-induced mitochondrial calcium accumulation, indicating its regulatory effect on high glucose-induced mitochondrial calcium homeostasis.	Cell Death Differ. 2021 Jan;28(1):184-202.
SH-SY5Y cells	100 nM	48 h	Urolithin A pretreatment significantly reduced high glucose-induced mtROS levels, indicating its inhibitory effect on high glucose-induced oxidative stress.	Cell Death Differ. 2021 Jan;28(1):184-202.
SH-SY5Y cells	100 nM	72 h	Urolithin A significantly reduced high glucose-induced LDH release, indicating its protective effect against high glucose-induced cell damage.	Cell Death Differ. 2021 Jan;28(1):184-202.
HEK293 APP-Swedish cells	30 μM	48 h	To investigate the effect of Urolithin A on Aβ42 expression in HEK293 APP-Swedish cells, results showed that UA decreased Aβ42 expression.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
HMC3 human microglia cells	30 μM	48 h	To investigate the effect of Urolithin A on Aβ42-induced inflammatory response in HMC3 cells, results showed that UA significantly reduced IL-1β expression.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
ARPE-19 cells	100 μM	24 h	UA restored viability in SI-treated ARPE-19 cells and reduced 4-HNE levels, indicating that UA maintained proteostasis by restoring autophagic flux.	Mol Neurodegener. 2024 Jun 18;19(1):49.
HepG2 cells	20 μM	24 h	To validate the role of MUP1 in UA-mediated alleviation of alcohol-induced ER stress, results showed that knockdown of MUP1 attenuated the beneficial effects of UA on ER stress-related proteins.	Gut Microbes. 2024 Jan-Dec;16(1):2367342.
BMDMs	5, 10, 25, 50 µM	24 h	To observe the effect of UA on BMDMs cell activity and inflammatory factors, it was found that UA treatment inhibited CM stimulation-induced elevated mRNA expression of IL-6 and TNF-α and decreased extracellular secretion of IL-6.	J Adv Res. 2025 Mar;69:125-138.
THP-1	5, 10, 25, 50 µM	24 h	To observe the effect of UA on THP-1 cell activity and inflammatory factors, it was found that UA treatment inhibited CM stimulation-induced elevated mRNA expression of IL-6 and TNF-α and decreased extracellular secretion of IL-6.	J Adv Res. 2025 Mar;69:125-138.
Th17 cells	5 µM	4 h	URA significantly inhibited the differentiation of CD4+ T cells into Th17 cells, reduced IL-17 secretion, and decreased the expression of Th17-related genes.	EBioMedicine. 2021 Feb;64:103227.
Bone marrow-derived dendritic cells (BM-DCs)	25 µM	18 h	URA inhibited the activation of BM-DCs, reduced the expression of co-stimulatory molecules CD80, CD86, and MHCII, and suppressed the secretion of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α, while increasing the expression of anti-inflammatory cytokine IL-10.	EBioMedicine. 2021 Feb;64:103227.
primary mouse cardiomyocytes	10 μg/mL	6 h	To evaluate the protective effect of UA on LPS-induced cardiomyocyte injury, the results showed that UA significantly improved cell viability and alleviated LPS-induced cardiomyocyte injury.	MedComm (2020). 2023 Dec 19;4(6):e459.

Mice	APP/PS1 mice, 3xTgAD mice, 3xTgAD/Pol β+/− mice	Oral gavage	200 mg/kg/day	Once daily for 5 months	To evaluate the effects of long-term UA treatment on cognitive function, olfactory function, synaptic function, Aβ and tau pathology, neuroinflammation, lysosomal function, and DNA damage in AD mice. The results showed that UA significantly improved learning, memory, and olfactory function in AD mice, reduced Aβ and tau pathologies, enhanced long-term potentiation, and induced mitophagy by increasing lysosomal functions.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
Mice	STZ-induced diabetic mouse model	Intraperitoneal injection	2.5 mg/kg	Once daily for 8 weeks	Urolithin A injection significantly inhibited STZ-induced expression of APP, BACE1, and p-Tau, as well as Aβ deposition, indicating its protective effect against diabetes-associated Alzheimer's disease pathology.	Cell Death Differ. 2021 Jan;28(1):184-202.
Mice	APP/PS1 mice, 3xTgAD mice, 3xTgAD/Pol β+/− mice	Oral gavage	200 mg/kg	Once daily for 5 months	To investigate the effect of long-term Urolithin A treatment on learning and memory in Alzheimer's disease mouse models, results showed that UA significantly improved learning and memory and reduced Aβ and tau pathologies.	Alzheimers Dement. 2024 Jun;20(6):4212-4233.
Mice	C57BL/6J wild-type mice	Intraperitoneal injection	2.3 mg/kg	Daily for 7 days	UA alleviated SI-induced neurodegeneration and preserved visual function. UA restored autophagic flux and triggered PINK1/Parkin-dependent mitophagy.	Mol Neurodegener. 2024 Jun 18;19(1):49.
C57BL/6J mice	Chronic alcohol-induced liver disease model	Oral gavage	200 mg/kg	Daily for 14 weeks	UA alleviated chronic alcohol-induced liver disease by modulating the gut-microbiota-liver axis, significantly improving alcohol-induced metabolic disorders and hepatic ER stress, and restoring gut microbiota dysbiosis.	Gut Microbes. 2024 Jan-Dec;16(1):2367342.
BALB/c mice	Breast cancer xenograft model	Dietary administration	2 g/kg	Two weeks	To observe the effect of UA on the breast cancer xenograft model, it was found that UA treatment significantly reduced tumor size and decreased IL-6 levels in the tumor environment.	J Adv Res. 2025 Mar;69:125-138.
C57BL/6 mice	Experimental autoimmune encephalomyelitis (EAE) model	Oral	25 mg/kg	Daily administration until the end of the experiment (30 days)	URA significantly alleviated the clinical symptoms of EAE mice, reduced inflammatory cell infiltration and demyelination in the central nervous system, and decreased the numbers of M1-type microglia and activated dendritic cells, while also reducing the infiltration of Th1/Th17 cells.	EBioMedicine. 2021 Feb;64:103227.
C57BL/6 mice	Severe acute pancreatitis-associated acute cardiac injury (SACI) model	Intraperitoneal injection	30 mg/kg	1 hour before and 3 hours after modeling, lasting for 24 hours	To investigate the cardioprotective effect of UA on SACI mice and its mechanisms, the results showed that UA significantly reduced serum levels of amylase, lipase, LDH, CK-MB, BNP, cTnT, cTnI, alleviated pathological damage to pancreatic and cardiac tissues, and reduced myocardial cell apoptosis and oxidative stress.	MedComm (2020). 2023 Dec 19;4(6):e459.

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 1143-70-0

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CAS No.: 1143-70-0

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed