Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-6-Methylpyridine
Nucleophilic Substitution: The chlorine atom can be substituted by a nucleophile, such as hydroxide ion or amine groups. This can lead to the formation of products such as 6-methylpyridine or substituted derivatives depending on the nucleophile used.
Aromatic Electrophilic Substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes for a hydrogen atom on the ring. The presence of the chlorine atom can influence the regioselectivity of the substitution reaction.
Grignard Reaction: The compound can react with a Grignard reagent (RMgX) to form a substituted product. The Grignard reagent acts as a nucleophile attacking the electrophilic carbon of the pyridine ring.
Reduction: The compound can undergo reduction reactions, where the chlorine atom or the pyridine ring can be reduced to form corresponding products, such as 6-methylpiperidine.
Metalation: The compound can react with strong bases or organometallic reagents to undergo metalation, leading to the formation of metal complexes or organometallic compounds.
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3-Bromo-2-chloro-6-methyl-5-nitropyridine
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2-(2-Chloro-6-methylpyridin-3-yl)acetic acid
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4-Bromo-6-chloro-2-methylpyridin-3-amine
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5-Bromo-2-chloro-4,6-dimethylnicotinonitrile
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Methyl 5-bromo-2-chloro-6-methylnicotinate
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