Home Chemistry Heterocyclic Building Blocks Pyridines 2-Methoxypyridine
Electrophilic aromatic substitution: 2-methoxypyridine can react with electrophiles such as acyl chlorides or alkyl halides to substitute the methoxy group with the electrophile.
Nucleophilic substitution: The methoxy group in 2-methoxypyridine can be replaced by a nucleophile under suitable conditions, such as with strong nucleophiles like Grignard reagents or organolithium compounds.
Metalation: The pyridine ring in 2-methoxypyridine can be metalated by treatment with strong bases such as butyllithium or lithium diisopropylamide (LDA), leading to the formation of a metal complex.
Oxidation: 2-methoxypyridine can undergo oxidation reactions to form various products, such as pyridine N-oxide, using oxidizing agents like hydrogen peroxide or peracids.
Reduction: The pyridine ring or the methoxy group in 2-methoxypyridine can be reduced under appropriate conditions, such as using reducing agents like lithium aluminum hydride or hydrogen in the presence of a catalyst.
Alkylation or acylation: 2-methoxypyridine can undergo alkylation or acylation reactions at the nitrogen atom or the oxygen atom of the methoxy group, respectively, using suitable alkylating or acylating agents.
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5-Bromo-3-(difluoromethyl)-2-methoxypyridine
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(S)-2-Amino-2-(6-methoxypyridin-2-yl)ethanol dihydrochloride
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(R)-1-(6-Methoxypyridin-3-yl)propan-1-amine dihydrochloride
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(S)-1-(2-Methoxypyridin-4-yl)ethanamine hydrochloride
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4-Iodo-2-methoxy-5-(trifluoromethyl)pyridine
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5-Chloro-3-(chloromethyl)-2-methoxypyridine
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3-Bromo-6-(chloromethyl)-2-methoxypyridine
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(2-Methoxy-5-nitropyridin-3-yl)boronic acid
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