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Chemical Structure| 5391-39-9 Chemical Structure| 5391-39-9
Chemical Structure| 5391-39-9

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Product Details of 1-ACETYL-2-IMIDAZOLIDINONE

CAS No. :5391-39-9
Formula : C5H8N2O2
M.W : 128.13
SMILES Code : CC(=O)N1CCNC1=O
MDL No. :MFCD00988254
InChI Key :JJWACYUTERPMBM-UHFFFAOYSA-N
Pubchem ID :79350

Safety of 1-ACETYL-2-IMIDAZOLIDINONE

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of 1-ACETYL-2-IMIDAZOLIDINONE

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5391-39-9 ]

[ 5391-39-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 5391-39-9 ]
  • [ 32202-61-2 ]
  • [ 67356-94-9 ]
  • 2
  • [ 5391-39-9 ]
  • [ 1075-35-0 ]
  • 5-chloro-2-methyl-3-(4,5-dihydro-1-H-imidazol-2-yl)-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With trichlorophosphate; In ethanol; at 50℃; for 8.5h;Heating / reflux; A mixture of <strong>[1075-35-0]5-chloro-2-methylindole</strong> (30.1 g; 0.18 mole) and 1-acetyl-imidazolidine-2-one (24 g; 0.18 mole) was added to phosphorous oxychloride (178 ml) and heated to 50 C. After 5 hours, phosphorous oxychloride was evaporated. The residue was treated with ethanol (250 ml) cautiously and maintained at reflux for 3.5 hours. The mixture was concentrated under reduced pressure to half of the orignal volume to obtain a precipitate, which was collected on a filter. The crystalline residue was treated with water, washed with ethylacetate, treated with 2N sodium hydroxide to pH 11 and stirred overnight. The precipitate was filtered, washed with water and t-butylmethylether and dried to give product (10.9 g, 26%), m.p. 213 C. [0467] 1H-NMR(DMSO): d 2.5 (s, 3H, CH-31), 3.55 (s, 4H, 2×CH-2), 6.30 (b, 1H, imidazolin), 7.04 (d, 1H 8.00 (s, 1H, H-4), 11.57 (b, 1H, NH-indol); MS (Ei 70 eV) m/Z 233M+.
  • 4
  • [ 5391-39-9 ]
  • [ 1075-34-9 ]
  • 5-bromo-3-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl-1H-indole hydrochloride [ No CAS ]
 

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