[ CAS No. 100929-33-7 ] {[proInfo.proName]}

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Quality Control of [ 100929-33-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 100929-33-7 ]

SDS Specification

Alternatived Products of [ 100929-33-7 ]

Product Details of [ 100929-33-7 ]

CAS No. :	100929-33-7	MDL No. :	MFCD09253729
Formula :	C₉H₁₃NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OZNSMUSCZYUFHD-VIFPVBQESA-N
M.W :	167.21	Pubchem ID :	10866717
Synonyms :

Safety of [ 100929-33-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 100929-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 100929-33-7 ]

[ 100929-33-7 ] Synthesis Path-Downstream 1~81

1
[ 75-21-8 ]
[ 100929-33-7 ]
[ 138713-42-5 ]

Reference： [1]Synthesis,1991,p. 996 - 998

2
[ 78307-39-8 ]
[ 100929-33-7 ]

Reference： [1]Chemische Berichte,1986,vol. 119,p. 2191 - 2207

3
[ 75-36-5 ]
[ 100929-33-7 ]
[ 100929-34-8 ]

Reference： [1]Chemische Berichte,1986,vol. 119,p. 2191 - 2207

4
[ 100929-33-7 ]
[ 91-13-4 ]
[ 209530-22-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1998,p. 2519 - 2526
[2]Tetrahedron Letters,1998,vol. 39,p. 4099 - 4102

5
[ 159848-74-5 ]
[ 100929-33-7 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium bicarbonate; In sodium hydroxide; hydrochloric methanol;	The process is performed under the conditions of Example 2, starting with 12.45 g of tert-butyl (1R)-1-(4-methoxyphenyl) -2-hydroxyethylcarbamate in 130 cm3 of 2.5 N hydrochloric methanol, with stirring for 1 h 30 minutes at a temperature in the region of 20 C., and then for 30 minutes at a temperature in the region of 30 C. The reaction mass is evaporated under reduced pressure (5 kPa) at a temperature in the region of 40 C. 61 cm3 of aqueous 5% sodium hydrogen carbonate solution are added to the residue obtained and the mixture is then extracted with 3 times 100 cm3 of dichloromethane. The aqueous phase is separated out after settling has taken place and is then evaporated as above. The solid obtained is taken up in 65 cm3 of aqueous 1 N sodium hydroxide solution and the resulting solution is reduced to 2/3 of its volume by concentration under the above conditions. The mixture is extracted with 3 times 100 cm3 of dichloromethane. The extracts are combined, dried over magnesium sulfate, filtered and evaporated under reduced pressure (5 kPa) at a temperature in the region of 40 C. The crystals obtained are dried under reduced pressure (5 kPa) at about 20 C. 5.86 g of (2R)-2-amino-2-(4-methoxyphenyl) -1-ethanol are obtained in the form of a white solid melting at 103 C. tert-Butyl (1R)-1-(4-methoxyphenyl)-2-hydroxyethylcarbamate:

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1998,p. 2519 - 2526
[2]Tetrahedron Letters,1998,vol. 39,p. 4099 - 4102
[3]Patent: US2002/19427,2002,A1

Yield	Reaction Conditions	Operation in experiment
52.71%	With lithium aluminium tetrahydride; In diethyl ether; for 3.0h;Reflux;	General procedure: Cryohydrate under bath, 2 - hydroxy -1 - phenyl ethyl oxime (4g, 26.5mmol) soluble in an amount of 40 ml anhydrous ethyl ether, is dropped into the containing lithium aluminum hydride (2.51g, 66 . 2mmol) ethyl ether suspension of 10 ml, then completing 30min, gradually heating to reflux, the reaction 3h. To be after the reaction is complete, under the ice salt bath, is dropped into the aqueous ether 2.5 ml, stirring 30min, then one by one 15% sodium hydroxide solution with 2.5 ml, continuing to stir 30min, add 7.5 ml water, stirring 1h, adding anhydrous magnesium sulfate, stirring 1h. Filtering, and for 20 ml of ethyl ether run filter washing cake. Drying of the organic layer with anhydrous magnesium sulfate, desolvation, yellow oily product obtained 0.58g, yield: 15.98%.

7
[ 57056-39-0 ]
[ 100929-33-7 ]
C₃₄H₃₇N₃O₆ [ No CAS ]

Reference： [1]Tetrahedron Letters,2000,vol. 41,p. 3941 - 3945

8
[ 50-00-0 ]
[ 100929-33-7 ]
(R)-4-(4-Methoxy-phenyl)-oxazolidine [ No CAS ]
(5R,10R)-5,10-bis(4-methoxyphenyl)-1,6-diaza-3,8-dioxabicyclo[4.4.1]undecane [ No CAS ]
C₂₁H₂₆N₂O₄ [ No CAS ]

Reference： [1]Heterocycles,2004,vol. 64,p. 277 - 289

9
[ 139152-08-2 ]
[ 100929-33-7 ]
(R,R)-1,2-dichloro-4,5-bis(4-(p-methoxyphenyl)oxazolin-2-yl)benzene [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2001,vol. 123,p. 2911 - 2912

10
[ 100929-33-7 ]
[ 5659-93-8 ]
2,2-bis[2-[4-(4-methoxyphenyl)-1,3-oxazolinyl]]propane [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2000,vol. 122,p. 1635 - 1649

11
[ 637-69-4 ]
diazotized 4-amino-benzonitrile [ No CAS ]
[ 100929-33-7 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1998,p. 2519 - 2526
[2]Tetrahedron Letters,1998,vol. 39,p. 4099 - 4102

12
[ 100929-33-7 ]
(1S)-N-methyl-1-(4-methoxyphenyl)-2-(isoindolin-2-yl)ethylamine [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 4099 - 4102

13
[ 100929-33-7 ]
C₁₇H₁₈NO⁽¹⁺⁾*Cl^(1-) [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 4099 - 4102

14
[ 100929-33-7 ]
[ 100929-27-9 ]

Reference： [1]Chemische Berichte,1986,vol. 119,p. 2191 - 2207

15
[ 100929-33-7 ]
3-Hydroxy-N-[(R)-2-hydroxy-1-(4-methoxy-phenyl)-ethyl]-3-phenyl-propionamide [ No CAS ]

Reference： [1]Chemische Berichte,1986,vol. 119,p. 2191 - 2207

16
[ 100929-33-7 ]
[ 138713-77-6 ]

Reference： [1]Synthesis,1991,p. 996 - 998

17
[ 100929-33-7 ]
[ 138713-47-0 ]

Reference： [1]Synthesis,1991,p. 996 - 998

18
[ 100929-33-7 ]
[ 138713-54-9 ]

Reference： [1]Synthesis,1991,p. 996 - 998

19
[ 100929-33-7 ]
[ 138713-43-6 ]

Reference： [1]Synthesis,1991,p. 996 - 998

20
[ 100929-33-7 ]
[ 138713-76-5 ]

Reference： [1]Synthesis,1991,p. 996 - 998

21
[ 100929-33-7 ]
[ 138713-51-6 ]

Reference： [1]Synthesis,1991,p. 996 - 998

22
[ 590-42-1 ]
[ 100929-33-7 ]
N-(tert-butyl)-N'-[(1R)-1-(4-methoxyphenyl)-2-hydroxyethyl]thiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In diethyl ether; ethanol; water;	The process is performed under the conditions of Example 1, starting with 5.78 g of <strong>[100929-33-7](2R)-2-amino-2-(4-methoxyphenyl)-1-ethanol</strong> and 6.48 cm3 of tert-butyl isothiocyanate in 73 cm3 of ethanol for 17 h 30 minutes at a temperature in the region of 20 C. The reaction mass is evaporated under reduced pressure (5 kPa) at a temperature in the region of 40 C. and the solid residue obtained is then ground in 45 cm3 of water, filtered and washed with twice 20 cm3 of water and twice 25 cm3 of diethyl ether. The crystals are dried in an oven under reduced pressure (10 Pa) at a temperature in the region of 45 C. 4.9 g of N-(tert-butyl)-N'-[(1R)-1-(4-methoxyphenyl)2-hydroxyethyl]-thiourea are obtained in the form of a white solid. (Rf=0.60 in ethyl acetate, on a Merck 60F254R silica plate). (2R)-2-Amino-2-(4-methoxyphenyl)-1-ethanol:

Reference： [1]Patent: US2002/19427,2002,A1

23
[ 590-42-1 ]
[ 100929-33-7 ]
N-(tert-butyl)-N'-[1-(4-methoxyphenyl)-2-hydroxyethyl]thiourea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In diethyl ether; ethanol; water;	N-(tert-Butyl)-N'-[1-(4-methoxyphenyl)-2-hydroxyethyl]thiourea: The process is performed under the conditions of Example 1, starting with 1.3 g of 2-amino -2-(4-methoxyphenyl)-1-ethanol and 1.46 cm3 of tert-butyl isothiocyanate in 12 cm3 of absolute ethanol for 21 hours at a temperature in the region of 20 C. After concentration of the reaction mass under reduced pressure (5 kPa) at a temperature in the region of 40 C., the residue obtained is taken up in 10 cm3 of water. A crystalline precipitate forms, which is filtered off, washed with 3 times 5 cm3 of diethyl ether and dried under reduced pressure (10 Pa) at a temperature in the region of 40 C. 1.32 g of N-(tert-butyl) -N'-[1- (4-methoxyphenyl)-2-hydroxyethyl]thiourea are obtained in the form of a white solid melting at 127 C. 2-Amino-2-(4-methoxyphenyl)-1-ethanol:

Reference： [1]Patent: US2002/19427,2002,A1

24
tert-butyl 1-(4-methoxyphenyl)-2-hydroxyethylcarbamate [ No CAS ]
[ 100929-33-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In methanol; sodium hydroxide; sodium bicarbonate;	A mixture of 3.4 g of tert-butyl 1-(4-methoxyphenyl)-2-hydroxyethylcarbamate in 32 cm3 of methanol containing 10% by mass of anhydrous hydrogen chloride is stirred for 1 hour at a temperature in the region of 20 C. The reaction medium is concentrated under reduced pressure (5 kPa) at a temperature in the region of 40 C. The residue is taken up in 9 cm3 of aqueous 5% sodium hydrogen carbonate solution and the mixture is then extracted with 3 times 30 cm3 of dichloromethane. The aqueous phase is concentrated as above and the white solid obtained is then taken up in 17 cm3 of aqueous 1 N sodium hydroxide solution. The precipitate is extracted with 3 times 30 cm3 of dichloromethane. The combined organic extracts are evaporated under reduced pressure (5 kPa) at a temperature in the region of 40 C. The white solid obtained is dried under reduced pressure (10 Pa) at a temperature in the region of 40 C. 1.3 g of 2-amino-2-(4-methoxyphenyl)-1-ethanol are obtained in the form of a white solid melting at 96 C. tert-Butyl 1-(4-methoxyphenyl)-2-hydroxyethylcarbamate:

Reference： [1]Patent: US2002/19427,2002,A1

25
[ 100929-33-7 ]
[ 67-64-1 ]
C₁₂H₁₇NO₂ [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6231 - 6236

26
[ 86790-89-8 ]
[ 100929-33-7 ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 6231 - 6236

27
[ 77568-43-5 ]
[ 100929-33-7 ]