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Chemical Structure| 102065-86-1 Chemical Structure| 102065-86-1

Structure of 102065-86-1

Chemical Structure| 102065-86-1

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Product Details of [ 102065-86-1 ]

CAS No. :102065-86-1
Formula : C3H8N2
M.W : 72.11
SMILES Code : NC1CNC1
MDL No. :MFCD06858460

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Application In Synthesis of [ 102065-86-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 102065-86-1 ]

[ 102065-86-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 93107-30-3 ]
  • [ 102065-86-1 ]
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[3'-amino-1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid [ No CAS ]
  • 2
  • [ 93107-30-3 ]
  • [ 101752-05-0 ]
  • [ 102065-86-1 ]
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[3'-amino-1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; EXAMPLE 2 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[3'-amino-1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid and its hydrochloride salt A mixture of 3-amino-1-azetidine (80 mg, 0.048 mmole), 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (10.6 mg, 0.04 mole) and DBU (0.0113 ml, 12.1 mg, 0.08 mmole) in 5 ml of acetonitrile was refluxed under nitrogen (79°-80° C.) for 3 hours and was then allowed to stand at room temperature under nitrogen overnight. The reaction mixture was then filtered and the wet cake was washed with acetonitrile and then with ethyl ether. The cake was then dried in vacuo to give 15 mg of the title compound, m.p. 277°-278° C. The hydrochloride salt of the title compound was prepared by adding 130 mg (0.04 mmole) of the title compound to methanolic HCl containing an equivalent amount (0.04 mmole) of HCl and stirring at room temperature for 4 hours. Crystals were collected by filtration, washed with ethyl ether and dried to give 22.3 mg of the hydrochloride salt, m.p. above 300° C. NMR (DMSO-D6): 1.12-1.13, d, and 1.26-1.28 d, 4H of cyclopropane, 3.8, s, 1H of cyclopropane; 4.05-4.25, m, 4H of C2 'and C4 'azetidine; 4.46-4.52, q, 1H of azetidine C3 '; 6.92-6.98, d, 1H of C8; 7.80-7.86, d, 1H of C5; 8.6, s, 1H of C2; 8.68-8.84, d, 2H of NH2.
 

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