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Chemical Structure| 102065-88-3 Chemical Structure| 102065-88-3

Structure of 102065-88-3

Chemical Structure| 102065-88-3

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Product Details of [ 102065-88-3 ]

CAS No. :102065-88-3
Formula : C5H10N2O
M.W : 114.15
SMILES Code : CC(NC1CNC1)=O
MDL No. :MFCD16876789

Safety of [ 102065-88-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 102065-88-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 102065-88-3 ]

[ 102065-88-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 93107-30-3 ]
  • [ 101752-05-0 ]
  • [ 102065-88-3 ]
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[3'-acetylamino-1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
83.7 mg (76%) With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; EXAMPLE 5 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3'-acetylamino-1'-azetidinyl]-4-oxo-3-quinoline-carboxylic acid and its hydrochloride salt A mixture of 3-acetylamino-1-azetidine (110 mg, 0.963 mmole), 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (212 mg, 0.8 mmole) and DBU (0.134 ml, 137 mg, 0.9 mmole) in 10 ml of acetonitrile were refluxed under nitrogen (79°-80° C.) for one hour and was then allowed to stand at room temperature under nitrogen overnight. The reaction mixture was then filtered and the wet cake was washed with acetonitrile and then with ethyl ether. The cake was then dried in vacuo to give 311 mg of the title compound. The hydrochloride salt was prepared by adding the title compound (100 mg) to methanolic HCl containing an equivalent amount of HCl and stirring at room temperature for 30 minutes. The solid material that formed was filtered, washed with acetonitrile, and dried in vacuo to give 83.7 mg (76percent) of the hydrochloride salt, m.p. 265°-266° C. dec.
 

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