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Chemical Structure| 106012-41-3 Chemical Structure| 106012-41-3

Structure of 106012-41-3

Chemical Structure| 106012-41-3

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Product Details of [ 106012-41-3 ]

CAS No. :106012-41-3
Formula : C16H15NO
M.W : 237.30
SMILES Code : O=C(NC1=CC=CC=C1C(C)=C)C2=CC=CC=C2

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Application In Synthesis of [ 106012-41-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106012-41-3 ]

[ 106012-41-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 52562-19-3 ]
  • [ 98-88-4 ]
  • [ 106012-41-3 ]
YieldReaction ConditionsOperation in experiment
99% With triethylamine; In dichloromethane; for 1h;Cooling with ice; 1: In a 100 mL three-necked flask, add methyl triphenylphosphonium bromide (5.36 g, 15 mmol) and dry THF 20 mL. Under the protection of argon, potassium tert-butoxide (1.68g, 15mmol) was added to the reaction flask in batches under ice bath, and after the addition, the reaction was carried out at room temperature for 30min. Then o-aminoacetophenone (1.21 g, 10 mmol) was added, and the reaction was carried out overnight. After the reaction was completed, saturated sodium bicarbonate was added, and the mixture was extracted with ethyl acetate. After the extract was concentrated, silica gel column chromatography was performed to obtain the corresponding o-propenylaniline (0.88 g, yield=74%). In a 100 mL single-neck flask, o-propenyl aniline (0.99 g, 7.4 mmol) and triethylamine (1.53 g, 11.1 mmol) were dissolved in 15 mL of dichloromethane. Under an ice bath, a dichloromethane solution of benzoyl chloride (1.0 mL, 8.9 mmol) was slowly added dropwise. The reaction was completed in about 1 hour. After silica gel column chromatography, the corresponding amide (3.89 g, yield=99%) was obtained. In a 100mL three-neck flask, add NaH (640mg, 60%wt, 16mmol), replace the gas in the flask with argon three times, add 15mL of dry THF, and add dropwise the THF solution with amide (700mg, 4mmol) dissolved in it. Reaction at 60C for 2h. Then, nitrile bromide was added to the reaction solution and moved to room temperature overnight. The reaction solution was suction filtered, and the filtrate was concentrated and subjected to silica gel column chromatography to obtain the target product 1 (448 mg). White solid, 56% yield
  • 2
  • [ 1391728-13-4 ]
  • [ 106012-41-3 ]
  • 4-fluoro-4-methyl-2-phenyl-4,5-dihydrobenzo[d]-1,3-oxazepine [ No CAS ]
 

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