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Chemical Structure| 108281-61-4 Chemical Structure| 108281-61-4

Structure of 108281-61-4

Chemical Structure| 108281-61-4

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Product Details of [ 108281-61-4 ]

CAS No. :108281-61-4
Formula : C14H13N3
M.W : 223.27
SMILES Code : NC1=CC=C2C(N=C(CC3=CC=CC=C3)N2)=C1
MDL No. :MFCD02765682

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Application In Synthesis of [ 108281-61-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 108281-61-4 ]

[ 108281-61-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 108281-61-4 ]
  • [ 63558-65-6 ]
  • [ 845658-32-4 ]
YieldReaction ConditionsOperation in experiment
73% In ethanol; for 16h;Heating / reflux; A mixture OF 4-CHLORO-5-IODOPYRIMIDINE (5.0 g, 21 MMOL) and 2-BENZYL-1H-BENZIMIDAZOL-5-AMINE (4.7 g, 21 MMOL) in absolute ethanol (250 mL) was refluxed for 16 h. The mixture was concentrated and partitioned between water containing hydrochloric acid (to pH 1) and ethyl acetate. The ethyl acetate layer was discarded. The aqueous layer was made basic by adding 50% sodium hydroxide solution (to pH 12) and extracted with ethyl acetate. The organic layer was dried and concentrated to an amber foam (6.2 g, 73%). The crude material was carried on to the next step. ESIMS : 429 (M+H)+
 

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