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Chemical Structure| 1108658-19-0 Chemical Structure| 1108658-19-0

Structure of 1108658-19-0

Chemical Structure| 1108658-19-0

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Product Details of [ 1108658-19-0 ]

CAS No. :1108658-19-0
Formula : C3H6FNO2S
M.W : 139.15
SMILES Code : O=S(C1(F)CC1)(N)=O
MDL No. :MFCD22690232

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Application In Synthesis of [ 1108658-19-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1108658-19-0 ]

[ 1108658-19-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1108658-19-0 ]
  • [ 1152134-45-6 ]
  • [ 1535210-08-2 ]
YieldReaction ConditionsOperation in experiment
0.73 g Step 1. Preparation of A12-1: A vessel containing a solution of carboxylic acid A9-1 (1 g, 4 mmol) in THE (15 mL) was treated with CDI (0.84 g, 5.2 mmol), sealed and heated to 75 00 for 2 h. The clear tan colored solution is divided in half and used subsequently without further purification for the remainder of Step 1 in the preparation of Intermediate A12 as well as the preparation ofIntermediate A13 as detailed below. This solution is treated with 1- fluorocyclopropane-1 -sulfonamide (0.42 g, 3 mmol; prepared according to Steps 1, 4, and 9 of Example 7 of International Patent Publication No. WO 2009/1 4730, p. 107-110) and DBU (0.6 mL, 4 mmol) and allowed to stir overnight at rt. The solution was acidified to pH -1 with 1 M HCI and concentrated in vacuo toremove the majority of THE. The aqueous layer was extracted with EtOAc and the combined organics washed with brine, dried over anhydrous Mg504 and concentrated in vacuo to dryness to afford 0.73 g of the A12-1 that was used without further purification.
 

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