Home Cart 0 Sign in  

[ CAS No. 1152134-45-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1152134-45-6
Chemical Structure| 1152134-45-6
Structure of 1152134-45-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1152134-45-6 ]

Related Doc. of [ 1152134-45-6 ]

Alternatived Products of [ 1152134-45-6 ]

Product Details of [ 1152134-45-6 ]

CAS No. :1152134-45-6 MDL No. :MFCD29920658
Formula : C10H15F2NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 251.23 Pubchem ID :-
Synonyms :

Calculated chemistry of [ 1152134-45-6 ]

Physicochemical Properties

Num. heavy atoms : 17
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.8
Num. rotatable bonds : 6
Num. H-bond acceptors : 6.0
Num. H-bond donors : 2.0
Molar Refractivity : 54.5
TPSA : 75.63 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.68 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.71
Log Po/w (XLOGP3) : 1.62
Log Po/w (WLOGP) : 2.46
Log Po/w (MLOGP) : 1.03
Log Po/w (SILICOS-IT) : 0.99
Consensus Log Po/w : 1.56

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.02
Solubility : 2.39 mg/ml ; 0.0095 mol/l
Class : Soluble
Log S (Ali) : -2.82
Solubility : 0.38 mg/ml ; 0.00151 mol/l
Class : Soluble
Log S (SILICOS-IT) : -1.41
Solubility : 9.86 mg/ml ; 0.0393 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 3.17

Safety of [ 1152134-45-6 ]

Signal Word:Warning Class:
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1152134-45-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1152134-45-6 ]

[ 1152134-45-6 ] Synthesis Path-Downstream   1~47

  • 1
  • [ 154350-29-5 ]
  • [ 1152134-45-6 ]
  • [ 1152134-46-7 ]
YieldReaction ConditionsOperation in experiment
45% The acid (0.6 g) was dissolved in DCM (10 mL)Cooling to 0 degrees,DMAP (0.73 g) was added sequentially,Cyclopropylsulfonamide (0.36 g) was stirred for 5 min,Then EDCI (1.14 g) was added to the reaction system,0 degrees reaction 1h,Room temperature reaction 24h,TLC detection of raw materials reaction is complete,There are new points generated,Add water (20mL),DCM (3 * 40 mL) was extracted with anhydrous sodium sulfate,The organic phase was concentrated and the column was chromatographed on a white solid (0.4 g, 45%).
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20℃; for 49h; Step 2B; <n="185"/>Carboxylic acid 2a (~ 132 mmol) was dissolved in DCM (400 mL) then cooled to 0 C. DMAP (40.3 g, 330 mmol), sulfonamide (16.0 g, 132 mmol), and EDC (63.3 g, 330 mmol) were added and reaction was stirred at 0 C for 1 h, warmed to rt, then stirred an additional 48 h. Reaction was diluted with EtOAC (1.5 L) and extracted with IN HCl (2 x 750 mL). Combined aqueous layers were back-extracted with EtOAc, and the combined EtOAc layers were washed with brine (1 L). Organic portions were dried (Na2SO4), filtered, and concentrated. Crude oil was purified via SiO2 chromatography using a 60% EtOAc/hexanes to yield the desired sulfonimide 2b (40 g, 85%, two steps).
  • 2
  • [ 1152134-42-3 ]
  • [ 1152134-45-6 ]
YieldReaction ConditionsOperation in experiment
95% A mixture of (1R,2R)-ethyl 1-(bis(tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropanecarboxylate (540 mg, 1.423 mmol) in Tetrahydrofuran (7 mL) and MeOH (7.00 mL) was added 2M LiOH (3.56 mL, 7.12 mmol) in water and stirred at rt over the weekend. It was then extracted with ether, the aqueous layer was acidified with 1N HCl until pH=3. It was then extracted with ethyl acetate, dried over MgSO4, filtered and concentrated to yield W=340 mg (95%) off-white solid. 1HNMR (500 MHz, MeOD) δ ppm 1.39-1.54 (m, 10H,) 1.64-1.87 (m, 1H), 1.88-2.11 (m, 1H,) 5.91 (t, J=55.85 Hz, 1H).
80% With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 50℃; for 10h; The starting material 53 as a solution in heptane is concentrated, chased with EtOH, and then dissolved in EtOH (6 mL/g of 53) and THF (6 mL/g of 53). The solution is heated to 50 C. and then a 5.5% aqueous solution of LiOH (5 eq) is added and the mixture stirred at 50 C. until the reaction is complete by high-performance liquid chromatographic (HPLC) analysis (approximately 10 h). The mixture is cooled to rt and formic acid (3.5 eq) is added and the mixture concentrated to approximately 7 mL/g. To this mixture is added isopropyl acetate (IPAc) (10 mL/g of 53) and formic acid (2.5 eq) to adjust the pH to 4.5. The mixture is filtered, rinsing with IPAc and the aqueous layer is separated. The upper product containing layer is washed with water, and then brine. The IPAc solution is concentrated and the product crystallized from IPAc/heptanes. The yield of 54 is typically 80%.
60.4% With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20℃; for 8h; The difluoro compound (0.5 g)Was dissolved in THF (6 mL)MeOH (2 mL) andH2O (2 mL)Lithium hydroxide (0.27 g) was then added to the reaction system,Reaction at room temperature for 8 h,TLC detection has product formation,Raw material reaction is complete,The reaction solution was diluted with 15 mL of water,Then 1NHCl adjusted to pH 3-4,Ethyl acetate was extracted three times,Dried over anhydrous sodium sulfate,The organic phase was concentrated and the column was chromatographed (0.2 g, yield: 60.4%) as a white solid.
Step 2A; Ethyl ester 11 (50 g, 132 mmol) was dissolved in THF (400 mL), then further diluted with MeOH (160 mL) and water (160 mL). LiOH-H2O (27.6 g, 660 mmol) was added and the reaction mixture was stirred at rt overnight. The solution was acidified to pH ~ 2 using 1 M HCl, then extracted with DCM (3 x 500 mL). The combined organic portions were dried (Na2SO4), filtered, and concentrated. The crude carboxylic acid 2a was carried directly on without any further purification.

  • 3
  • [ 1152134-45-6 ]
  • [ 1229446-97-2 ]
  • [ 1229446-98-3 ]
YieldReaction ConditionsOperation in experiment
25.09% To a solution of <strong>[1152134-45-6](1R,2R)-1-(tert-butoxycarbonylamino)-2-(difluoromethyl)cyclopropanecarboxylic acid</strong> (100 mg, 0.398 mmol) in Tetrahydrofuran (4 mL) was added CDT (84 mg, 0.517 mmol) and the formed solution was stirred at r.t. for 3 h. 1-(hept-6-enyl)cyclopropane-1-sulfonamide (104 mg, 0.478 mmol) and DBU (0.120 mL, 0.796 mmol) were added and the reaction continued at r.t. overnight. The reaction was diluted with EtOAc. Washed with 5% citric acid, brine, dried over MgSO4, filtered and concentrated. The residue was purified by Biotage column, eluted with gradient 5%70% EtOAc-Hexane to afford the desire produce tert-butyl (1R,2R)-2-(difluoromethyl)-1-(1-(hept-6-enyl)cyclopropylsulfonylcarbamoyl)cyclopropylcarbamate (45 mg, 0.100 mmol, 25.09% yield). 1H NMR (400 MHz, CHLOROFORM-D) ppm 0.95 (s, 2H) 1.28-1.36 (m, 2H) 1.36-1.47 (m, 6H) 1.52 (s, 9H) 1.58-1.67 (m, 2H) 1.72 (d, J=10.54 Hz, 1H) 1.78-1.95 (m, 2H) 1.97-2.12 (m, 3H) 4.88-5.05 (m, 2H) 5.23 (b, NH) 5.65-5.92 (m, 2H) 9.20 (b, NH).
  • 4
  • [ 1108658-19-0 ]
  • [ 1152134-45-6 ]
  • [ 1535210-08-2 ]
YieldReaction ConditionsOperation in experiment
0.73 g Step 1. Preparation of A12-1: A vessel containing a solution of carboxylic acid A9-1 (1 g, 4 mmol) in THE (15 mL) was treated with CDI (0.84 g, 5.2 mmol), sealed and heated to 75 00 for 2 h. The clear tan colored solution is divided in half and used subsequently without further purification for the remainder of Step 1 in the preparation of Intermediate A12 as well as the preparation ofIntermediate A13 as detailed below. This solution is treated with 1- fluorocyclopropane-1 -sulfonamide (0.42 g, 3 mmol; prepared according to Steps 1, 4, and 9 of Example 7 of International Patent Publication No. WO 2009/1 4730, p. 107-110) and DBU (0.6 mL, 4 mmol) and allowed to stir overnight at rt. The solution was acidified to pH -1 with 1 M HCI and concentrated in vacuo toremove the majority of THE. The aqueous layer was extracted with EtOAc and the combined organics washed with brine, dried over anhydrous Mg504 and concentrated in vacuo to dryness to afford 0.73 g of the A12-1 that was used without further purification.
  • 5
  • [ 1152134-45-6 ]
  • C8H11F3N2O3S*(x)ClH [ No CAS ]
  • 7
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,23aR,23bS)-6-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-15-fluoro-4,7-dioxo-1a,2,2a,4,5,6,7,10,11,19,20,21,22,23,23a,23b-hexa-decahydro-1H,9H-8,11-methanocyclopropa[4',5']cyclopenta[1',2':18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-9-carboxamide trifluoroacetate [ No CAS ]
  • 8
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,20E,23aR,23bS)-6-tert-butyl-15-cyano-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-19,19-difluoro-4,7-dioxo-1a,2,2a,4,5,6,7,10,11,19,22,23,23a,23b-tetradecahydro-1H,9H-8,11-methanocyclopropa[4',5']cyclopenta [1',2':18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-9-carboxamide trifluoroacetate [ No CAS ]
  • 9
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,23aR,23bS)-6-tert-butyl-15-cyano-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-19,19-difluoro-4,7-dioxo-1a,2,2a,4,5,6,7,10,11,19,22,23,23a,23b-tetradecahydro-1H,9H-8,11-methanocyclopropa[4',5']cyclopenta [1',2':18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-9-carboxamide trifluoroacetate [ No CAS ]
  • 10
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,23aR,23bS)-6-tert-butyl-N-[(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-(difluoromethyl)cyclopropyl]-19,19-difluoro-4,7-dioxo-1a,2,2a,4,5,6,7,10,11,19,20,21 ,22,23,23a,23b-hexadecahydro-1H,9H-8,11-methanocyclopropa[4',5']cyclopenta[1',2':18,19][1,10,3,6]dioxadiaza-cyclononadecino[11,12-b]quinoxaline-9-carboxamide trifluoroacetate [ No CAS ]
  • 11
  • [ 1152134-45-6 ]
  • (33R,35S,91S,93R,94R,95S,5S)-5-(tert-butyl)-17-cyano-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(3,4)-bicyclo[3.1.0]hexanacyclotetradecaphane-35-carboxamide trifluroacetate [ No CAS ]
  • 12
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,24aR,24bS)-6-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-4,7,18-trioxo-1a,2,2a,4,5,6,7,10,11,20,21,22,23,24,24a,24b-hexadecahydro-1H,9H,18H-8,11-methanocyclopropa[4',5']cyclopenta[1',2':18,19][1,10,3,6,12]dioxatriazacyclononadecino[11,12-b]quinazoline-9-carboxamide trifluroacetate [ No CAS ]
  • 13
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,24aR,24bS)-6-tert-butyl-15-cyano-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-4,7,18-trioxo-1a,2,2a,4,5,6,7,10,11,20,21,22,23,24,24a,24b-hexadecahydro-1H,9H,18H-8,11-methanocyclopropa[4',5']cyclopenta[1',2':18,19][1,10,3,6,12]dioxatriazacyclononadecino[11,12-b]quinazoline-9-carboxamide trifluroacetate [ No CAS ]
  • 14
  • [ 1152134-45-6 ]
  • (1aS,2aR,6S,9S,11R,24aR,24bS)-6-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-15-methoxy-4,7,18-trioxo-1a,2,2a,4,5,6,7,10,11,20,21,22,23,24,24a,24b-hexadecahydro-1H.9H.18H-8.11-methanocyclopropa[4',5']cyclopenta[1',2':18,19][1,10,3,6,12]dioxatriazacyclonona decino[11,12-b]quinazoline-9-carboxamide trifluroacetate [ No CAS ]
  • 15
  • [ 669008-26-8 ]
  • [ 1152134-45-6 ]
  • C14H22F2N2O5S [ No CAS ]
YieldReaction ConditionsOperation in experiment
31 g With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20℃; for 36h; Preparation of Intermediate A10. Step 1 . Preparation of A10-1 : A solution of A9-1 (25 g, 100 mmol) and 1 - methylcyclopropane-1 -sulfonamide (prepared according to Example 1 .2 of International Patent Publication No. WO 2008/064066, p. 47; 15g, 1 10 mmol) in DCM (330 mL) was treated with DMAP (24.4 g, 200 mmol) followed by slow addition of EDC (38.3 g, 200 mmol) at 0 C. After addition was completed, the mixture stirred vigorously at 0 C and allowed to warm rt over 36 h. The reaction was diluted with EtOAc (300 mL). The organic layer was washed with 10% citric acid (3X30 mL) and sat. NaHCOs (2X20 mL). The combined aqueous washes were extracted once with EtOAc. The combined organic layers were washed with brine (2X25 mL), dried over anhydrous Na2SO , filtered and concentrated in vacuo. After trituration with hexane/EtOAc (10/1 ), acyl sulfonamide A10-1 (31 g) was obtained as a white solid.
The acid 54 (10.0 g, 39.8 mmol, 1.0 equiv.), 1-methylcyclopropane-1-sulfonamide 55 (6.49 g, 48.0 mmol, 1.20 equiv), and HATU (17.86 g, 47.0 mmol, 1.18 equiv) were charged to a 250 ml, flask followed by 120 mL of acetonitrile. Then 2,6-lutidine (5.5 mL, 51.5 mmol, 1.29 equiv.) was added dropwise maintaining an internal temperature below 25 C. The solution was stirred for 30 minutes and then cooled to 10 C. DMAP (19.45 g, 159.2 mmol, 4.0 equiv) was added in several portions over 6 minutes maintaining an internal temperature below 15 C. The resulting slurry was stirred overnight at 20 C. The reaction was filtered and the solids were washed with 30 mL of IPAc. IPAc (76 mL) was added to the filtrate and the solution washed with 20 wt % phosphoric acid (3×80 mL), 2 wt % phosphoric acid (1×80 mL), and water (5×80 mL). The IPAc solution of 56 was used directly in the next reaction.
  • 16
  • [ 1159609-95-6 ]
  • [ 1152134-45-6 ]
  • 19
  • C18H31NO8 [ No CAS ]
  • [ 1152134-45-6 ]
  • 21
  • [ 1152134-45-6 ]
  • [ 1152134-47-8 ]
  • 22
  • [ 1152134-45-6 ]
  • C40H46F2N6O11S [ No CAS ]
  • 23
  • C12H19F2NO4 [ No CAS ]
  • [ 1152134-45-6 ]
YieldReaction ConditionsOperation in experiment
80% With water; lithium hydroxide; In acetonitrile; at 20℃; A solution of the Boc amino ethyl ester 79 (2 g, 7.16 mmol) in acetonitrile (10 mL) was treated with a solution of LiOH (193 mg, 7.88 mmol 1.1 equiv) in water (10 mL). The mixture was stirred at ambient temperature overnight. Upon reaction completion, 15% aqueous citric acid was added to achieve a pH of 4-4.5. The mixture was concentrated under vacuum to remove the acetonitrile and the resulting mixture was diluted with 5 mL water. The resulting slurry was mixed overnight at ambient temperature, filtered and washed with 4 mL water. The wet cake was dried in a vacuum oven to give an isolated yield of 80%.
80% With lithium hydroxide; In water; acetonitrile; at 20℃; Saponification (0291) (0292) A solution of the Boc amino ethyl ester 79 (2 g, 7.16 mmol) in acetonitrile (10 mL) was treated with a solution of LiOH (193 mg, 7.88 mmol 1.1 equiv) in water (10 mL). The mixture was stirred at ambient temperature overnight. Upon reaction completion, 15% aqueous citric acid was added to achieve a pH of 4-4.5. The mixture was concentrated under vacuum to remove the acetonitrile and the resulting mixture was diluted with 5 mL water. The resulting slurry was mixed overnight at ambient temperature, filtered and washed with 4 mL water. The wet cake was dried in a vacuum oven to give an isolated yield of 80%.
  • 25
  • [ 1152134-45-6 ]
  • glecaprevir [ No CAS ]
  • 26
  • C9H12F2O4 [ No CAS ]
  • [ 1152134-45-6 ]
  • 28
  • C8H10F2O4*C12H23N [ No CAS ]
  • [ 1152134-45-6 ]
  • 29
  • C12H19F2NO4 [ No CAS ]
  • [ 1152134-45-6 ]
  • 30
  • C8H10F2O4*C8H11N [ No CAS ]
  • [ 1152134-45-6 ]
  • 31
  • C10H14F2O4 [ No CAS ]
  • [ 1152134-45-6 ]
  • 32
  • (1S,2R)-2-(difluoromethyl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid [ No CAS ]
  • [ 75-65-0 ]
  • [ 1152134-45-6 ]
YieldReaction ConditionsOperation in experiment
2.37 g First, isopropyl ether (78 ml) was added to 5.66 g (17.2 mmol) of the compound of the following formula obtained in Example 19. The resulting mixture was stirred at room temperature, followed by adding thereto a 1M aqueous phosphoric acid solution (43 ml). The mixture was further stirred for 30 minutes. Then, the mixture was left still for 20 minutes and thereby separated into two layers. The aqueous layer was removed. The organic layer was mixed with water (50 ml), stirred for 30 minutes and left still for 20 minutes. The organic layer was recovered and concentrated by a rotary evaporator. As a result, a compound of the following formula was obtained in an amount of 3.29 g (15.8 mmol). To 3.29 g (15.8 mmol) of this compound, toluene (32 ml), trimethylamine (3.20 g, 31.6 mmol) and t-butanol (3.51 g, 47.4 mmol) were added at room temperature. The resulting solution was heated to 70 C. Then, diphenylphosphoryl azide (6.52 g, 23.7 mmol) was gradually dropped into the solution. After the dropping, the solution was reacted for 15 hours while the temperature of the solution was set to 80 C. After the reaction, the solution was subjected to solvent evaporation by a rotary evaporator. The concentration residue was mixed by stirring with isopropyl ether (50 ml) and water. The resulting mixture was separated into two layers. The organic layer was recovered and similarly subjected to two-layer separation by mixing and stirring with water (35 ml). The organic layer was recovered and concentrated by a rotary evaporator, thereby yielding a crude product. A solution of potassium hydroxide (1.14 g, 20.4 mmol) in methanol (10 ml) was added to the crude product at room temperature. The resulting solution was subjected to hydrolysis reaction for 5 hours at 40 C. This reaction solution was cooled by ice water. Then, a 1M aqueous phosphoric acid solution (20 ml) was gradually added to the reaction solution. Further, diisopropyl ether (50 ml) was added to the solution. The solution was stirred for 30 minutes at room temperature and separated into two layers. The organic layer was mixed with water (20 ml). The mixture was stirred for 30 minutes at room temperature and then separated into two layers. The thus-extracted organic layer was recovered and concentrated by a rotary evaporator. As a result, a compound of the following formula was obtained in an amount of 2.37 g (9.4 mmol). In the above formula, Boc represents a tert-butoxycarbonyl group.
  • 33
  • C8H10F2O4 [ No CAS ]
  • [ 1152134-45-6 ]
  • 34
  • C8H10F2O4*C8H11N [ No CAS ]
  • [ 1152134-45-6 ]
  • 35
  • C8H10F2O4 [ No CAS ]
  • [ 1152134-45-6 ]
  • 41
  • [ 1152134-42-3 ]
  • [ 1152134-45-6 ]
  • [ 1160633-68-0 ]
  • 43
  • [ 1152134-45-6 ]
  • [(3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17,3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide] [ No CAS ]
  • 44
  • [ 1152134-45-6 ]
  • [ 530-62-1 ]
  • C13H17F2N3O3 [ No CAS ]
  • 45
  • (±)-2-(difluoromethyl)-1-(ethoxycarbonyl)cyclopropanecarboxylic acid dicyclohexylamine salt [ No CAS ]
  • [ 1152134-45-6 ]
  • 47
  • [ 1152134-45-6 ]
  • C14H21F2NO6S [ No CAS ]
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 1152134-45-6 ]

Amino Acid Derivatives

Chemical Structure| 1936649-94-3

[ 1936649-94-3 ]

1-((tert-Butoxycarbonyl)amino)-3,3-difluorocyclopentanecarboxylic acid

Similarity: 0.92

Chemical Structure| 1098188-08-9

[ 1098188-08-9 ]

2-((tert-Butoxycarbonyl)amino)-2-(1-(trifluoromethyl)cyclopropyl)acetic acid

Similarity: 0.92

Chemical Structure| 1196151-58-2

[ 1196151-58-2 ]

1-((tert-Butoxycarbonyl)amino)-4,4-difluorocyclohexanecarboxylic acid

Similarity: 0.91

Chemical Structure| 1936649-94-3

[ 1936649-94-3 ]

1-((tert-Butoxycarbonyl)amino)-3,3-difluorocyclopentanecarboxylic acid

Similarity: 0.92

Chemical Structure| 1098188-08-9

[ 1098188-08-9 ]

2-((tert-Butoxycarbonyl)amino)-2-(1-(trifluoromethyl)cyclopropyl)acetic acid

Similarity: 0.92