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Chemical Structure| 113258-84-7 Chemical Structure| 113258-84-7

Structure of 113258-84-7

Chemical Structure| 113258-84-7

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Product Details of [ 113258-84-7 ]

CAS No. :113258-84-7
Formula : C8H6BrIO
M.W : 324.94
SMILES Code : O=C(C1=CC=CC=C1I)CBr
MDL No. :MFCD13194409

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Application In Synthesis of [ 113258-84-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 113258-84-7 ]

[ 113258-84-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 113258-84-7 ]
  • [ 10167-97-2 ]
  • 2-(2-iodophenyl)-6-methoxyimidazo[1,2-a]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With sodium hydrogencarbonate; In ethanol; at 90℃; for 2h; General procedure: Substituted 2-(2-iodophenyl)imidazo[1,2-a]pyridines were synthesized by using the modified method for 1a2. To a solution of 2-bromo-1-(2-iodophenyl)ethanone (975 mg, 3 mmol) and sodium bicarbonate (378 mg, 4.5 mmol, 1.5 eq.) in ethanol (8 mL) was added 2-aminopyridine (282 mg, 3 mmol, 1 eq.) and the reaction mixture was stirred at 90 C for 2 h. The reaction mixture was allowed to cool to room temperature and the volatiles were evaporated. The residue was diluted with water (100 mL) and extracted into dichloromethane (100 mL). The organic layer was extracted into saturated aqueous sodium bicarbonate solution. After that, it was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The crude residue was purified by column chromatography (1:1 = n-hexane: AcOEt) to obtain 1b-1k. In the case of 1l, the precipitates were washed with CH2Cl2 followed by recrystallization from n-hexane/CHCl3 to give 1l.
  • 2
  • [ 113258-84-7 ]
  • [ 10167-97-2 ]
  • 8-methoxybenzo[4',5']selenopheno[3',2':4,5]imidazo[1,2-a]pyridine [ No CAS ]
 

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