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[ CAS No. 1207852-61-6 ] {[proInfo.proName]}

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Chemical Structure| 1207852-61-6
Chemical Structure| 1207852-61-6
Structure of 1207852-61-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1207852-61-6 ]

CAS No. :1207852-61-6 MDL No. :MFCD17392784
Formula : C8H9ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 184.62 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1207852-61-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1207852-61-6 ]

[ 1207852-61-6 ] Synthesis Path-Downstream   1~7

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YieldReaction ConditionsOperation in experiment
45% Preparation of compound 13b: 3-(6-chloropyrazin-2-yl)-6- (trifluoromethyl)imidazo[1,2-a]pyridine13a (328 mg, 1.92 mmol) was dissolved in dioxane-water (6 ml_:3 mL) and treated with NBS (285 mg, 1.60 mmol) in one portion which gave a light yellow solution.Solution stirred for 10 min at room temperature. 2-amino-5-(trifluoromethyl)pyhdine(260 mg, 1.60 mmol) was added and the reaction mixture was heated in the microwave for 10 min at 100 0C. The crude reaction was diluted with EtOAc (35 mL) and NaHCO3 (sat, aq) (20 ml_). The aqueous phase was back extracted with EtOAc (25 ml_) The combined extracts were washed with brine (35 ml_) then dried (MgSO4) filtered and concentrated. The crude product was purified by column chromatography (EtOAc/MeOH) which gave the title compound 13b as a beige solid (265 mg, 45%). 1 H NMR (300 MHz, DMSO-c/6) delta ppm 7.76 (dd, J=9.4, 1.9 Hz, 1 H) 8.00 (d, J=9.4 Hz, 1 H) 8.67 (s, 1 H) 8.83 (s, 1 H) 9.39 (s, 1 H) 10.04 (s, 1 H).
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