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Chemical Structure| 1235406-40-2 Chemical Structure| 1235406-40-2

Structure of 1235406-40-2

Chemical Structure| 1235406-40-2

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Product Details of [ 1235406-40-2 ]

CAS No. :1235406-40-2
Formula : C9H5FN4O2S2
M.W : 284.29
SMILES Code : O=S(C1=CC=C(F)C(C#N)=C1)(NC2=NC=NS2)=O

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Application In Synthesis of [ 1235406-40-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1235406-40-2 ]

[ 1235406-40-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2040-90-6 ]
  • [ 1235406-40-2 ]
  • 4-(2-chloro-6-fluorophenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 150℃; for 3h; General procedure: A 0.1 875M solution in NMP of the compound of formula (Pa) (400 tL, 75 jtmol) was added to the compound of formula (IV) (90 jtmol) followed by cesium carbonate (47 mg, 150 tmol). The reaction mixture was shaken and heated to 150° C. for 3 hours before cooling and concentrating in vacuo. The residue was dissolved in DM50 (1 mL) and purified using preparative HPLC as described below to afford the desired compound of formula (Ia). Preparative HPLC/LCMS Conditions:Mobile phase A:0.05percent TFA in water; Mobile phaseB: MeCN Column: Welch XB-C18 (2.1x50 mm, 5 u)The compounds of the Examples in the table belowwere prepared from 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (W02012004743) and the appropriUSate phenol according to Library Protocol 4.
 

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