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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Potassium acetate is an inorganic salt that regulates cell osmotic pressure and maintains acid-base balance. Potassium acetate is primarily used in buffer preparation, biochemical research, and medical applications.
Synonyms: Diuretic salt; Potassium ethanoate
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Rajapaksha, Ishanka Nirmani ;
Abstract: Small organic dyes are used in many applications, such as heat absorbers, solar cells, biological imaging, and photodynamic therapies for cancers. Xanthene-based dyes exhibit unique structural features and photophysical properties, and good water solubility, allowing them to be used as biological sensory materials. Conventional xanthene dyes (eg: fluorescein and rhodamine) have their absorptions and emissions in the visible region, which limits their use in cellular imaging. Absorptions and emissions at longer wavelengths allow for low background cellular autofluorescence, deep tissue penetration, and minimum cell damage. Chapter I discusses the background of fluorescent dyes and the importance of near-infrared (NIR) emissive dyes for biological applications. Chapter II is based on the design and synthesis of new xanthene-based NIR I dyes using simple and short synthetic routes. This study used pyrrole and indole as donor molecules and combined them to the xanthene core by the Suzuki cross-coupling reaction to prepare the new dyes. After the treatment with trifluoroacetic acid, these new dyes transformed from their non-fluorescent to fluorescent forms and exhibited excellent red shifts in their maximum absorption and emission wavelengths. The novel pyrrole-based xanthene dye was used to investigate the efficacy of the dye as a probe for fluoride ions. We were able to modify this dye with a silyl ester receptor and develop a probe as a colorimetric turn-off fluoride ion sensor. In chapter III, we describe the synthesis of different NIR emissive xanthene dyes using the donor-acceptor-donor concept. New xanthene-based dyes were designed with five-membered heterocycles and fused heteronuclear molecules. Additionally, xanthene-based dyes containing an alkyne spacer were synthesized using the D-pi-A model to extend the pi-conjugation through the alkyne spacer. All of the dyes exhibited absorption and emission maxima in the visible to NIR I region, between 500-850 nm. In chapter IV, we discussed the synthesis of xanthene-based electrochromic materials. These compounds used xanthene as the chromophore and ferrocene as the electrophore units. Novel rhodamine-based symmetric and unsymmetric dyes were synthesized by attaching the ferrocene unit through the lactam ring. The compounds were then investigated as an electrochromic probe using UV-vis , cyclic voltammetry, and spectroelectrochemical analysis.
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CAS No. : | 127-08-2 |
Formula : | C2H3KO2 |
M.W : | 98.14 |
SMILES Code : | CC([O-])=O.[K+] |
Synonyms : |
Diuretic salt; Potassium ethanoate
|
MDL No. : | MFCD00012458 |
InChI Key : | SCVFZCLFOSHCOH-UHFFFAOYSA-M |
Pubchem ID : | 517044 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In acetonitrile; at 20℃; for 14h; | 2.7 g (10.80 mmol) of <strong>[78502-71-3]ethyl 2-(bromomethyl)thiazole-4-carboxylate</strong> are dissolved in 108 mL of acetonitrile. 2.225 g (22.67 mmol) of potassium acetate are added and the medium is stirred at room temperature for 14 hours.The resulting mixture is concentrated under reduced pressure. The residue obtained is taken up in aqueous sodium chloride solution and extracted twice with dichloromethane. The combined organic phases are dried over sodium sulfate, filtered and concentrated to dryness. 2.347 g (95%) of expected product are obtained in the form of a wax.1H NMR (CDCl3) delta (ppm) : 8.15 (s, 1H); 5.35 (s, 2H); 4.35 (dq, 2H); 2.10 (s, 3H); 1.35 (t, 3H). |
In acetonitrile; at 20℃; for 14h; | 2.7 g (10.80 mmoles) of ethyl 2-(bromomethyl) thiazole-4-carboxylate are dissolved in 108 ml of acetonitrile. 2.225 g (22.67 mmoles) of potassium acetate are added and the mixture is stirred for 14 hrs at ambient temperature.It is concentrated under reduced pressure. The residue obtained is taken up in a saturated aqueous solution of sodium chloride and extracted twice with dichloromethane. The combined organic phases are dried over sodium sulphate, filtered and concentrated to dryness. 2.347 g of the expected product are obtained in the form of a wax.1H NMR (CDCl3) delta (ppm): 8.15 (s, 1H); 5.35 (s, 2H); 4.35 (qd, 2H); 2.10 (s, 3H); 1.35 (t, 3H). |