Stage #1: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667 h; Stage #2: With sodium tetrahydroborate In water; ethyl acetate at 0℃; for 0.416667 h;
General procedure: To a solution of carboxylic acid (10 mmol) in THF (10 mL), DIPEA (11 mmol, 1.42 mL) and 50percent T3P in EtOAc (20 mmol, 6.36 mL) were added at 0 °C and the solution was stirred for about 10 min. Then aqueous solution of NaBH4 (10 mmol, 388 mg in 0.3 mL of H2O) was added to the reaction mixture at the same temperature and the reaction was allowed to stir till the completion of the reaction as indicated by TLC. After the completion of the reaction, the solvent was evaporated and the crude alcohol was extracted into EtOAc and the organic phase was washed with 5percent citric acid (10 mL .x. 2), 5percent Na2CO3 (10 mL .x. 2), water, and brine solution. The product was isolated after the evaporation of solvent under reduced pressure and dried over anhydrous Na2SO4.
Reference：
[1] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5059 - 5063
[2] Journal of Organic Chemistry, 2001, vol. 66, # 25, p. 8454 - 8462
[3] Tetrahedron Letters, 2000, vol. 41, # 32, p. 6131 - 6135
[4] Organic Letters, 2008, vol. 10, # 10, p. 1881 - 1884
[5] Tetrahedron Letters, 1999, vol. 40, # 23, p. 4395 - 4396
[6] Tetrahedron Asymmetry, 1998, vol. 9, # 11, p. 1855 - 1858
[7] Journal of Organic Chemistry, 1993, vol. 58, # 8, p. 2313 - 2316
[8] Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5260 - 5266
[9] Synthetic Communications, 2009, vol. 39, # 19, p. 3555 - 3566
[10] Journal of Organic Chemistry, 2014, vol. 79, # 17, p. 8422 - 8427
[11] ACS Combinatorial Science, 2017, vol. 19, # 3, p. 131 - 136
[12] Organic and Biomolecular Chemistry, 2018, vol. 16, # 26, p. 4874 - 4880
2
[ 3182-95-4 ]
[ 28920-43-6 ]
[ 129397-83-7 ]
Yield
Reaction Conditions
Operation in experiment
89%
at 20℃; for 0.0333333 h; Sonication; Irradiation; Green chemistry
General procedure: Amine (1 mmol) and Fmoc-Cl (1.1 mmol) were placed in a glass tube under neat conditions and were sonicated for a suitable time (as indicated in Tables 1, 2 and 3). All reactions were performed in a water bath at room temperature. After completion of the reaction (as indicated by TLC), 5 cm3 of diethyl ether was added to the mixture. The N-Fmoc derivatives were crystallized and were obtained in good to excellent yields. Purification of the product was accomplished by recrystallization from diethyl ether.
Reference：
[1] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 404 - 414
[2] Journal of the Brazilian Chemical Society, 2016, vol. 27, # 3, p. 546 - 550
[3] Journal of Organic Chemistry, 1995, vol. 60, # 2, p. 405 - 410
[4] Journal of the American Chemical Society, 2006, vol. 128, # 12, p. 4023 - 4034
3
[ 146803-43-2 ]
[ 129397-83-7 ]
Reference：
[1] Tetrahedron, 2004, vol. 60, # 39, p. 8703 - 8709
[2] Journal of Organic Chemistry, 1993, vol. 58, # 8, p. 2313 - 2316
[3] Synthetic Communications, 2007, vol. 37, # 20, p. 3493 - 3499
4
[ 129397-81-5 ]
[ 129397-83-7 ]
Reference：
[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 3, p. 761 - 765
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