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Chemical Structure| 132771-10-9 Chemical Structure| 132771-10-9

Structure of 132771-10-9

Chemical Structure| 132771-10-9

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Product Details of [ 132771-10-9 ]

CAS No. :132771-10-9
Formula : C6H15ClN2
M.W : 150.65
SMILES Code : CC1(N(C)C)CNC1.[H]Cl
MDL No. :MFCD22123304

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Application In Synthesis of [ 132771-10-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 132771-10-9 ]

[ 132771-10-9 ] Synthesis Path-Downstream   1~1

  • 1
  • 1-cyclopropyl-6-fluoro-7-(3-dimethylamiono-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid [ No CAS ]
  • [ 132771-10-9 ]
  • [ 93107-30-3 ]
  • 1-cyclopropyl-6-fluoro-7-(3-dimethylamino-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In pyridine; water; EXAMPLE 4 Preparation of 1-cyclopropyl-6-fluoro-7-(3-dimethylamino-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid A mixture of 1.32 g (5 mmol) of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.31 g (7 mmol) of 3-methyl-3-dimethylaminoazetidine hydrochloride and 3 ml of triethylamine in 10 ml of pyridine is heated to reflux for 2 hours. The mixture is evaporated and allowed to cool, ice-cold water is added, the resulting mixture is filtered, the product is washed with water, ethanol and ether and 1.8 g of 1-cyclopropyl-6-fluoro-7-(3-dimethylamiono-3-methyl-1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, melting point 298°-301° C., are thereby obtained. Spectroscopic data: 1 H NMR, delta,J=HZ, [DMSO-TFAA]; 1.16 (m, 4H); 1.67 (s, 3H); 2.78 (s, 6H); 3.67 (m, 1H); 4.29 (AB, J=20, J=9.3, 4H); 7.0 (d, J=7.5, 1H); 7.85 (d, J=12.9, 1H); 8.6 (s, 1H). IR(KBr).-1712, 1629, 1521, 1476 cm-1.
 

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