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Chemical Structure| 13343-63-0

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Zhichang Zhang ; Weicheng Wang ; Peng Xu ; Quanjun Cui ; Xinlin Yang ; Ameer E. Hassan

Abstract: (NAG) is a natural amino sugar found in various human tissues with previously described anti-inflammatory effects. Various chemical modifications of have been made to promote its biomedical applications. In this study, we synthesized two bi-deoxygenated , BNAG1 and BNAG2 and investigated their anti-inflammatory properties, using an in vivo and in vitro inflammation mouse model induced by lipopolysaccharide (LPS). Among the parent molecule , BNAG1 and BNAG2, BNAG1 showed the highest inhibition against serum levels of IL-6 and TNF α and the leukocyte migration to lungs and peritoneal cavity in LPS challenged mice, as well as IL-6 and TNF α production in LPS-stimulated primary peritoneal macrophages. BNAG2 displayed an anti-inflammatory effect which was comparable to . These findings implied potential application of these novel derivatives, especially BNAG1, in treatment of certain inflammation-related diseases.

Keywords: ; Bi-deoxygenation ; Infammation ; Macrophages

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Product Details of [ 13343-63-0 ]

CAS No. :13343-63-0
Formula : C22H25NO6
M.W : 399.44
SMILES Code : CC(N[C@@H]1[C@@H](O)[C@]2([H])OC(C3=CC=CC=C3)OC[C@@]2([H])O[C@@H]1OCC4=CC=CC=C4)=O
MDL No. :MFCD00143679
InChI Key :NXGXFAKJUWEFEC-NVZUTRPHSA-N
Pubchem ID :2735220

Safety of [ 13343-63-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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