Home Cart Sign in  
Chemical Structure| 1393921-62-4 Chemical Structure| 1393921-62-4

Structure of 1393921-62-4

Chemical Structure| 1393921-62-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1393921-62-4 ]

CAS No. :1393921-62-4
Formula : C14H16O3
M.W : 232.28
SMILES Code : CC(C1=CC=C(OC)C2=C1OC(C)(C)C=C2)=O
MDL No. :MFCD24387388

Safety of [ 1393921-62-4 ]

Application In Synthesis of [ 1393921-62-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1393921-62-4 ]

[ 1393921-62-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1393921-62-4 ]
  • [ 31680-08-7 ]
  • (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxy-3-nitrophenyl)prop-2-en-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
79.5% With potassium hydroxide; In methanol; water; at 0℃; for 12h; A solution of 50% KOH (20 mL, aq)wasadded dropwise to a stirred solution of compound 4 (2.3 g,6.46 mmol) and compound 5 (1.8 g, 6.46 mmol) in methanol (40 mL) at 0 C. The resulting mixture was stirred at the sametemperature for 12 h and monitored by TLC. After completion of reaction, the mixture was poured into ice-water and adjusted to pH = 2 with 4 N HCl. The precipitated was filtered, washed withwater and dried to offer the crude product which was purified bychromatography on silica gel eluted with petroleum ether/ethylacetate (V:V = 4:1, 3:1, 2:1) to give the intermediate compound 6 as a yellow solid (yield: 3.1 g, 79.5%). 4.1.3 E)-1-(5-Methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxy-3-nitrophenyl)prop-2-en-1-one (61H NMR (300 MHz, CDCl3) δ 8.14 (s, 1H, ArH), 7.75-7.70 (m, 3H, ArH, Ph-CO-CH=CH-, overlapped signals), 7.59 (d, J = 15.8 Hz, 1H, Ph-CO-CH=CH-), 7.12 (d, J = 8.7 Hz, 1H, ArH), 6.69 (d, J = 10.0 Hz, 1H, Ph-CH=CH-C(CH3)2), 6.53 (d, J = 8.9 Hz, 1H, ArH), 5.64 (d, J = 10.0 Hz, 1H, Ph-CH=CH-C(CH3)2), 4.00 (s, 3H, -OCH3), 3.89 (s, 3H, -OCH3), 1.52 (s, 6H, 2 * -CH3) ppm. HR-MS (m/z) (ESI): calcd for C22H21NO6 [M+H]+: 396.1447; found: 396.1430.
  • 2
  • [ 39974-94-2 ]
  • [ 1393921-62-4 ]
  • (E)-3-(5-methoxy-1-methyl-1H-indol-3-yl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)prop-2-en-1-one [ No CAS ]
  • 3
  • [ 1393921-62-4 ]
  • [ 31680-08-7 ]
  • C22H21NO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
74.5% With potassium hydroxide; In methanol; water; at 0℃; A solution of 50% KOH (25 mL, aq) wasadded dropwise to a stirred solution of 4 (4.6 g, 12.92 mmol) and 5(3.6 g, 12.92 mmol) in methanol (50 mL) at 0 C and stirred at the sametemperature for overnight. After completion of reaction, the mixturewas poured into ice-water (300 mL), and adjusted to pH = 2-3 withcon.HCl. The precipitated was filtered, washed with water and dried tooffer the crude product which was purified by chromatography on silicagel eluted with petroleum ether/ethyl acetate to obtain compound 6 as a yellow solid (yield: 3.8 g, 74.5%). 1H NMR (600 MHz, CDCl3) δ 8.15(d, J = 2.1 Hz, 1H), 7.75-7.73 (m, 2H), 7.71 (d, J = 3.3 Hz, 1H), 7.60(d, J = 15.7 Hz, 1H), 7.12 (d, J = 8.7 Hz, 1H), 6.69 (d, J = 10.0 Hz,1H), 6.53 (d, J = 8.9 Hz, 1H), 5.64 (d, J = 10.0 Hz, 1H), 4.00 (s, 3H),3.89 (s, 3H), 1.51 (s, 6H). HR-MS (m/z) (ESI): calcd for C22H21NO6 [M+H]+: 396.1447; found: 396.1441.
 

Historical Records

Technical Information

Categories