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Chemical Structure| 13961-37-0 Chemical Structure| 13961-37-0

Structure of 13961-37-0

Chemical Structure| 13961-37-0

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Product Details of [ 13961-37-0 ]

CAS No. :13961-37-0
Formula : C6H14N2
M.W : 114.19
SMILES Code : CCC1CNCCN1
MDL No. :MFCD03265494

Safety of [ 13961-37-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H226-H314
Precautionary Statements:P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P233-P501
Class:8(3)
UN#:2734
Packing Group:

Application In Synthesis of [ 13961-37-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13961-37-0 ]

[ 13961-37-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 13961-37-0 ]
  • [ 13925-00-3 ]
  • 2
  • [ 93107-30-3 ]
  • [ 13961-37-0 ]
  • PD 160793 [ No CAS ]
  • 3
  • [ 13925-00-3 ]
  • 16,17,18,19,28,29-hexahydro-4-O-acetyl-11-acetoxy-3-[2-ethyl-4-(2,4,6-trimethylbenzyl)-piperazin-1-yl]-8-O-pivaloyl-1-deoxy-11,15-dideoxo-1,15-oxy-rifamycin [ No CAS ]
  • [ 13961-37-0 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate; acetic acid; In ethanol; dichloromethane; EXAMPLE 41 In the same manner as outlined in Examples 15 and 20, 3-[2-ethyl-4-(2,4,6-tri-methylbenzyl)-piperazin-1-yl]-8-O-pivaloyl-1-deoxy-15-deoxo-1,15-oxy-rifamycin SV, (isomer A), mp 125°-128°, is converted to 16,17,18,19,28,29-hexahydro-4-O-acetyl-11-acetoxy-3-[2-ethyl-4-(2,4,6-trimethylbenzyl)-piperazin-1-yl]-8-O-pivaloyl-1-deoxy-11,15-dideoxo-1,15-oxy-rifamycin SV, mp 152°-155°, MW: 1100 (found: MS); C62 H89 N3 O14. The starting material can be prepared, for example, in the following way: A mixture of <strong>[13925-00-3]2-<strong>[13925-00-3]ethylpyrazine</strong></strong> (15 g), platinum oxide (800 mg), ethanol (150 ml) and acetic acid (1.5 g) is hydrogenated at 45 psi for 8 hours at room temperature. It is filtered and the filtrate concentrated to an oil which is taken up in methylene chloride, treated with sodium carbonate for 0.5 hour, filtered and concentrated to dryness to white solid 2-ethylpiperazine, mp 56°-57°.
  • 4
  • [ 13925-00-3 ]
  • [ 13961-37-0 ]
YieldReaction ConditionsOperation in experiment
91% With palladium 10% on activated carbon; hydrogen; In ethanol; at 20℃; under 2585.81 Torr; for 7h; To a stirred mixture of 2-<strong>[13925-00-3]ethyl pyrazine</strong> (1.0 g, 0.0092 mol., 1.0 eq) in ethanol (20 ml), 10percent Pd on carbon (0.1 g, 50percent wet) was added and stirred at rt under H2 atmosphere at 50 Psi for 7 h. After TLC showed completion of starting material, the mixture was filtered through Celite® bed and washed with ethanol (10 mL). The filtrate was concentrated to afford 2-ethyl piperazine (0.91 g, 91percent).
 

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