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[ CAS No. 14432-16-7 ]

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Chemical Structure| 14432-16-7
Chemical Structure| 14432-16-7
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Product Details of [ 14432-16-7 ]

CAS No. :14432-16-7 MDL No. :MFCD00955617
Formula : C5H3ClN2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :174.54 g/mol Pubchem ID :-
Synonyms :

Safety of [ 14432-16-7 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P280-P305+P351+P338-P311 UN#:2811
Hazard Statements:H301+H311+H331-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 14432-16-7 ]

  • Upstream synthesis route of [ 14432-16-7 ]
  • Downstream synthetic route of [ 14432-16-7 ]

[ 14432-16-7 ] Synthesis Path-Upstream   1~15

  • 1
  • [ 14432-16-7 ]
  • [ 2770-01-6 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5941 - 5952
  • 2
  • [ 14432-16-7 ]
  • [ 3243-24-1 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5941 - 5952
  • 3
  • [ 14432-16-7 ]
  • [ 73583-37-6 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 4
  • [ 14432-16-7 ]
  • [ 153034-86-7 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 5
  • [ 14432-16-7 ]
  • [ 14432-12-3 ]
Reference: [1] Tetrahedron, 1999, vol. 55, # 41, p. 11985 - 11996
[2] Journal of Chemical Research, Miniprint, 1997, # 6, p. 1359 - 1376
[3] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[4] Chem.Abstr., 1956, p. 12045
[5] Journal fuer Praktische Chemie (Leipzig), 1988, vol. 330, # 1, p. 154 - 158
[6] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5941 - 5952
  • 6
  • [ 14432-16-7 ]
  • [ 142-96-1 ]
  • [ 14432-12-3 ]
Reference: [1] Patent: US4808722, 1989, A,
  • 7
  • [ 14432-16-7 ]
  • [ 33252-30-1 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 8
  • [ 14432-16-7 ]
  • [ 6313-54-8 ]
Reference: [1] Roczniki Chemii, 1955, vol. 29, p. 1019,1025[2] Chem.Abstr., 1956, p. 12045
  • 9
  • [ 14432-16-7 ]
  • [ 23056-36-2 ]
YieldReaction ConditionsOperation in experiment
78% With phosphorus trichloride In chloroform at 20℃; Heating / reflux Reference Example 17: 2-Chloro-4-nitro-pyridine. Phosphorus trichloride (4.2 mL, 48.7 mmol) was-added_to a solution of 2- chloro-4-nitro-pyridine-l -oxide (1.70 g, 9.74 mmol) in dry chloroform (25 mL) at r.t.The reaction mixture was then heated to reflux and maintained at this temperature overnight. The reaction was cooled to r.t. then poured onto ice, basified to between pH7-8 with saturated aq. sodium bicarbonate solution and extracted with chloroform (x 2).The combined organic phase was washed with water and brine, dried over sodium sulfate and concentrated. Drying under high vacuum afforded 2-chloro-4-nitro-pyridine(1.2 g, 78 percent) as a solid.
Reference: [1] Journal of Organic Chemistry, 2009, vol. 74, # 19, p. 7441 - 7448
[2] Patent: WO2008/62182, 2008, A1, . Location in patent: Page/Page column 114
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 2674
  • 10
  • [ 14432-16-7 ]
  • [ 2604-39-9 ]
  • [ 2789-25-5 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5941 - 5952
  • 11
  • [ 14432-16-7 ]
  • [ 2604-39-9 ]
  • [ 2789-25-5 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5941 - 5952
  • 12
  • [ 14432-16-7 ]
  • [ 38767-72-5 ]
Reference: [1] Tetrahedron, 1999, vol. 55, # 41, p. 11985 - 11996
  • 13
  • [ 14432-16-7 ]
  • [ 4487-50-7 ]
Reference: [1] Journal of Molecular Structure, 1997, vol. 415, # 1-2, p. 53 - 63
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1836 - 1846
[3] Patent: WO2011/146591, 2011, A1,
[4] Patent: US2012/15942, 2012, A1,
[5] Patent: EP3305788, 2018, A1,
  • 14
  • [ 14432-16-7 ]
  • [ 35980-77-9 ]
Reference: [1] Pharmaceutical Chemistry Journal, 1972, vol. 6, # 3, p. 146 - 149[2] Khimiko-Farmatsevticheskii Zhurnal, 1972, vol. 6, # 3, p. 18 - 21
  • 15
  • [ 14432-16-7 ]
  • [ 25194-01-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
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[ 14432-16-7 ]

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