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Chemical Structure| 1454682-77-9 Chemical Structure| 1454682-77-9

Structure of 1454682-77-9

Chemical Structure| 1454682-77-9

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Product Details of [ 1454682-77-9 ]

CAS No. :1454682-77-9
Formula : C9H13NS
M.W : 322.26
SMILES Code : O=S(C(F)(F)F)(OC1=CC2=CN=C(NC)N=C2N=C1C)=O

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Application In Synthesis of [ 1454682-77-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1454682-77-9 ]

[ 1454682-77-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1454682-74-6 ]
  • [ 1454682-77-9 ]
  • [ 1454682-72-4 ]
YieldReaction ConditionsOperation in experiment
77% With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In 1,4-dioxane; water; at 50.0℃;Inert atmosphere; Combine l-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)urea (25.9 g, 68.5 mmol), 7-methyl-2-(methylamino)pyrido[2,3- d]pyrimidin-6-yl trifluoromethanesulfonate (22.09 g, 68.5 mmol), and NaHC03 (17.28 g, 206 mmol) in 1,4-dioxane (500 mL) and water (125 mL) and sparge with argon for 20 minutes. Add tetrakis(triphenylphosphine)palladium (3.96 g, 3.43 mmol) and then heat under argon at 50 C. Add additional portion of 7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl trifluoromethanesulfonate (300 mg, 0.55 mmol) and continue heating at 50 C overnight. Cool the mixture to RT, collect the solid by filtration, and wash with water then diethyl ether. Treat the solid with acetonitrile (50 mL) and heat the slurry at 80 C for 30 minutes. Collect the solid by filtration, wash with acetonitrile and dry under vacuum at 80 C to obtain a pale yellow solid. Treat the solid with MeOH (50 mL), and heat the mixture at 80 C for 1 hour. Cool to RT, collect the solid via filtration, wash with MeOH (20 mL), and dry under vacuum to obtain the title compound (22.5 g, 77% yield) as a pale yellow solid. MS (m/z): 425.2 (M+l).
 

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