Home Cart 0 Sign in  

[ CAS No. 15268-31-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 15268-31-2
Chemical Structure| 15268-31-2
Structure of 15268-31-2 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 15268-31-2 ]

Related Doc. of [ 15268-31-2 ]

Alternatived Products of [ 15268-31-2 ]

Product Details of [ 15268-31-2 ]

CAS No. :15268-31-2 MDL No. :MFCD01075747
Formula : C6H4N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 120.11 Pubchem ID :-
Synonyms :

Safety of [ 15268-31-2 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P264-P270-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P311-P321-P330-P333+P313-P337+P313-P363-P403+P233-P405-P501 UN#:2811
Hazard Statements:H302-H317-H319-H331-H334 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 15268-31-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15268-31-2 ]

[ 15268-31-2 ] Synthesis Path-Downstream   1~36

  • 1
  • [ 102308-97-4 ]
  • [ 15268-31-2 ]
  • N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-urea [ No CAS ]
  • 2
  • [ 15268-31-2 ]
  • [ 85696-95-3 ]
  • N-(1-Methyl-1H-indol-4-yl)-N'-(pyridin-3-yl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
With toluene In dichloromethane at 20℃; for 17h;
  • 3
  • [ 15268-31-2 ]
  • [ 102308-54-3 ]
  • 1-(1-Methyl-1H-indol-7-yl)-3-pyridin-3-yl-urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
With toluene In dichloromethane at 20℃; for 17h;
  • 4
  • [ 41910-64-9 ]
  • [ 15268-31-2 ]
  • 4-chloro-1-(3-pyridylcarbamoyl)indoline [ No CAS ]
  • 5
  • [ 80166-90-1 ]
  • [ 15268-31-2 ]
  • 5-bromo-7-nitro-1-(3-pyridylcarbamoyl)indoline [ No CAS ]
  • 6
  • [ 52537-00-5 ]
  • [ 15268-31-2 ]
  • 6-Chloro-1-(pyridin-3-ylcarbamoyl)indoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% Example 19 6-Chloro-1-(3-pyridylcarbamoyl)indoline (E19) The title compound was prepared as in the method of (Example 2) from 3-pyridylisocyanate and <strong>[52537-00-5]6-chloroindoline</strong> (D36) to give (E19) (1.54 g, 73%) m.p. 204-5 C. NMR (DMSO-d6) delta: 3.19 (2H, t, J=8), 4.19 (2H, t, J=8), 6.93-6.99 (1H, m), 7.23 (1H, d, J=8), 7.31-7.38 (1H, m), 7.88 (1H, s), 7.94-8.02 (1H, m), 8.24 (1H, d, J=6), 8.72 (1H, s), 8.82 (1H, s). Found: C, 61.34; H, 4.60; N, 15.38 C14 H12 N3 OCl requires: C, 61.43; H, 4.42; N, 15.35
  • 7
  • [ 65826-95-1 ]
  • [ 15268-31-2 ]
  • 5-methyl-1-(3-pyridylcarbamoyl)indoline [ No CAS ]
  • 9
  • [ 15268-31-2 ]
  • [ 162100-55-2 ]
  • 5-Trifluoromethyl-1-(pyridin-3-ylcarbamoyl)indoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% Example 22 5-Trifluoromethyl-1-(3-pyridylcarbamoyl)indoline (E22) The title compound was prepared as in the method of (Example 2) from 3-pyridylisocyanate and <strong>[162100-55-2]5-trifluoromethylindoline</strong> (D43) to give (E22) (0.12 g, 38%) m.p. 188-189 C. NMR (DMSO-d6) delta: 3.28 (2H, t, J=8), 4.22 (2H, t, J=8), 7.31-7.37 (1H, m), 7.47-7.57 (2H, m), 7.95-8.03 (2H, m), 8.24 (1H, d, J=6), 8.75 (1H, s), 8.90 (1H, s). MH+ 308 C15 H12 N3 OF3 H+ requires 308
  • 11
  • [ 46004-37-9 ]
  • [ 15268-31-2 ]
  • 2-chloro-4-(3-pyridin-3-yl-ureido)-benzoic acid methyl ester [ No CAS ]
  • 12
  • [ 35216-39-8 ]
  • [ 15268-31-2 ]
  • 1-(3-methanesulfonyl-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 13
  • [ 35944-64-0 ]
  • [ 15268-31-2 ]
  • 1-(3-iodo-4-methyl-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 15
  • [ 6575-11-7 ]
  • [ 15268-31-2 ]
  • 1-(3-chloro-2-cyano-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 18
  • [ 16017-69-9 ]
  • [ 15268-31-2 ]
  • 2-chloro-4-(3-pyridin-3-yl-ureido)-benzoic acid ethyl ester [ No CAS ]
  • 21
  • [ 20925-27-3 ]
  • [ 15268-31-2 ]
  • 1-(3-chloro-4-cyano-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 22
  • [ 54730-35-7 ]
  • [ 15268-31-2 ]
  • 1-(3,5-dichloro-4-methyl-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 25
  • [ 15268-31-2 ]
  • [ 2476-29-1 ]
  • 1-(4-acetyl-3-hydroxy-phenyl)-3-pyridin-3-yl-urea [ No CAS ]
  • 26
  • [ 15268-31-2 ]
  • [ 303994-99-2 ]
  • 1-(4-<i>tert</i>-butyl-5-cyano-thiazol-2-yl)-3-pyridin-3-yl-urea [ No CAS ]
  • 27
  • [ 102308-97-4 ]
  • [ 4013-72-3 ]
  • ethereal hydrogen chloride [ No CAS ]
  • [ 15268-31-2 ]
  • N-(1-Methyl-1H-indol-5-yl)-N'-(3-pyridyl)urea hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; dichloromethane; toluene; Method B A solution of the aminoindole (D3)(1.95 g; 13 mM) in dichloromethane (20 ml) was added dropwise to a solution of 3-pyridyl isocyanate (D4) (prepared from 3-pyridinecarbonyl azide (2.14 g; 15 mM) in toluene) at room temperature. The reaction mixture was stirred for 17 h, then cooled, and the precipitate filtered off to give the crude product (3.36 g; 95%). This was dissolved in hot ethanol and ethereal hydrogen chloride added to afford the title compound as its hydrochloride salt (3.1 g; 80%) identical with the material prepared by method A.
  • 28
  • ethereal hydrogen chloride [ No CAS ]
  • [ 15268-31-2 ]
  • [ 85696-95-3 ]
  • N-(1-Methyl-1H-indol-4-yl)-N'-(pyridin-3-yl)urea hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; dichloromethane; toluene 5 N-(1-Methyl-1H-indol-4-yl)-N'-(3-pyridyl)urea hydrochloride (E5) STR4 EXAMPLE 5 N-(1-Methyl-1H-indol-4-yl)-N'-(3-pyridyl)urea hydrochloride (E5) STR4 A solution of the aminoindole (D10) (0.44 g; 3.01 mM) in dichloromethane (10 ml) was added dropwise to a solution of 3-pyridyl isocyanate (D4) (prepared from 3-pyridine carbonyl azide (0.51 g; 3.4 mM) in toluene) at room temperature. The reaction mixture was stirred for 17 h, then cooled and the precipitate filtered off to give the crude product (1 g; 100%). This was dissolved in hot ethanol and ethereal hydrogen chloride added to afford the title compound as its hydrochloride salt (0.74 g; 81%), m.p 238° C. NMR (D6 DMSO) δ: 3.79 (3H, s), 6.80 (1H, d, J=3), 7.11 (2H, dd, J=6, 6), 7.30 (1H, d, J=3), 7.70 (1H, dd, J=6, 2), 7.90 (1H, m), 8.33 (1H, d, J=6), 8.49 (1H, d, J=3), 9.13 (1H, d, J=2), 9.40 (1H, s), 10.80 (1H, s).
  • 29
  • [ 60-27-5 ]
  • [ 7440-44-0 ]
  • [ 15268-31-2 ]
  • [ 76536-81-7 ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; methanol; chloroform; EXAMPLE II Procedure 2 described above is exemplified by the preparation of 1-(3-pyridinyl)-3-tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea 11. To a solution of 2.13 g (17.8 mM) of 3-pyridinylisocyanate 10 in 30 ml of dimethylformamide was added 2.0 g (17.8 mM) of <strong>[60-27-5]creatinine</strong> 7. The mixture was stirred at 90-95 C. for 3 hrs. and then cooled to form a precipitate. The solid was collected, washed with ether, and then chromatographed over silica gel using 5% methanol in chloroform as the eluent. The fractions containing the product were combined, treated with charcoal, filtered, and the filtrate diluted with ether to precipitate 1.1 g of 1-(3-pyridinyl)-3-(tetra hydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea 11 as pale yellow crystals, m.p. 200-201 C. (dec.).
  • 30
  • [ 301673-16-5 ]
  • [ 15268-31-2 ]
  • [ 1002339-07-2 ]
YieldReaction ConditionsOperation in experiment
34.6% In tetrahydrofuran; at 0 - 20℃; for 1h; To a solution of <strong>[301673-16-5]tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate</strong> (300 mg, 1.39 mmol) in tetrahydrofuran (6 ml) was added pyridine-3-isocyanate (251 mg, 2.09 mmol) under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of hexane and ethyl acetate to give the object product (162 mg, 34.6percent) as a solid. 1H-NMR (CDCl3) delta; 1.41 (9H, s), 2.90 - 3.05 (3H, m), 3.44 - 3.48 (2H, m), 3.87 - 4.02 (3H, m), 4.18 (1H, br s), 4.91 - 4.95 (1H, m), 7.24 - 7.28 (1H, m), 7.83 - 7.86 (1H, m), 8.13 - 8.15 (1H, m), 8.61 (1H, s), 8.66 (1H, s).
  • 31
  • [ 53406-38-5 ]
  • [ 15268-31-2 ]
  • [ 1048333-33-0 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; toluene; at 0 - 20℃; for 24h; EXAMPLE 1; N-(1H-indol-1-yl)-N'-(3-pyridyl)urea; A solution of 1.14 g of the compound of Preparation 1 in 38 ml of toluene is heated at reflux under argon until the starting material has completely disappeared (2 hours). To the 3-pyridyl isocyanate obtained as intermediate and cooled to 0 C. there are added 995 mg of 1H-indolamine in 38 ml of dichloromethane. Stirring is continued at ambient temperature for 24 hours. The precipitate formed is filtered off and stirred for 12 hours in water (10 ml). After filtering and washing with pentane, the solid is taken up in a dichloromethane/methanol mixture (90/10). Following filtration, the solid is dried in vacuo over phosphorus pentoxide to yield the expected product.Melting Point : 202.5 C.
  • 32
  • [ 1197159-91-3 ]
  • [ 15268-31-2 ]
  • [ 1197159-92-4 ]
YieldReaction ConditionsOperation in experiment
56% With dmap; In dichloromethane; at 20℃; for 48h; To a stirred mixture of <strong>[1197159-91-3]4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline</strong> (140 mg, 0.40 mmoles) and a catalytic amount of dimethylaminopyridine (DMAP) in methylene chloride 100 (mL), was added a small excess of aryl isocyanate (0.61 mmoles). The mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated to half of its original volume and the separated precipitate was collected by filtration and washed with methanol (15 ml) and then with diethyl ether. In some cases the crude product obtained was purified by Silica gel column chromatography by eluting it with appropriate solvents, depending upon the polarity of the products.The following compounds were prepared according to Procedure A:Example 2Preparation of 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-3-ylureaStarting from <strong>[1197159-91-3]4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline</strong> (0.08 g 0.23 mmoles) and 3-pyridyl isocyanate (30 mg, 0.25 mmoles) the title compound was isolated as a white solid. The product was purified by Silica gel column chromatography by eluting it with 10% MeOH: ethyl acetate. Yield; 60 mg (56%); (M+H)=463.5.
56% With dmap; In dichloromethane; at 20℃; for 48h; General procedure: To a stirred mixture of <strong>[1197159-91-3]4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline</strong> (140 mg, 0.40 mmoles) and a catalytic amount of dimethylaminopyridine (DMAP) in methylene chloride 100 (mL), was added a small excess of aryl isocyanate (0.61 mmoles). The mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated to half of its original volume and the separated precipitate was collected by filtration and washed with methanol (15 ml) and then with diethyl ether. In some cases the crude product obtained was purified by Silica gel column chromatography by eluting it with appropriate solvents, depending upon the polarity of the products.
  • 33
  • [ 1014-25-1 ]
  • [ 15268-31-2 ]
  • 1-(5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-(pyridine-3-yl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
In toluene; for 10h;Reflux; General procedure: A mixture of substituted benzoic acid (3 mmol) and triethylamine (3.3 mmol) in anhydrous toluene 40 mL was stirring for 45 min at room temperature. To the above reaction mixture DPPA (3.6 mmol) was added and heated to 40C for 1 h. Then the reaction mixture was refluxed for 3 h. After cooling to room temperature, intermediate 3a-k (3 mmol) was added and refluxed for 10 h. Cooled to room temperature and concentrated to give the crude product. The crude product was refluxed in 50 mL methanol for 0.5 h. After cooling, the mixture was filtered and the solid was collected as target product.
  • 34
  • [ 24878-25-9 ]
  • [ 15268-31-2 ]
  • 1,1'-[oxybis(2,1-phenylene)] bis(3-pyridin-3-ylurea) [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.07 g In toluene; acetonitrile; for 1.5h;Inert atmosphere; Reflux; L. Nicotinic acid acyl azide and bis(2-aminophenyl) ether were synthesized according to previous literatures [24-26], respectively. A solution of nicotinic acid acyl azide (1.04?g, 7.0?mmol) in toluene (30?mL) was refluxed under nitrogen for 1.5?h, and bis(2-aminophenyl) ether (0.60?g, 3.0?mmol) in acetonitrile (30?mL) was added dropwise. The mixture was stirred for another 1.5?h and cooled to room temperature. The precipitate that formed was collected by filtration and purified by recrystallization from CH3OH/DMF(V: V?=?2:1) to give a white solid. Yield: 1.07?g, 81%; mp: 285???286?C. 1H NMR (DMSO-d6, 400?MHz): delta 6.84 (d, 2H, J?=?7.6?Hz, Ar-H), 7.02 (t, 2H, J?=?5.2?Hz, Ar-H), 7.18 (t, 2H, J?=?5.6?Hz, Ar-H), 7.36 (dd, 2H, J?=?2.8?Hz, Ar-H), 7.99 (m, 2H, Py-H), 8.23 (d, J?=?2.8?Hz, 2H, Py-H), 8.35 (d, J?=?6.8?Hz, 2H, Py-H), 8.61 (s, 2H, Py-H), 8.75 (s, 2H, CONH), 9.52 (s, 2H, CONH). 13C NMR (DMSO-d6, 400?MHz): delta 152.98, 145.76, 143.53, 140.33, 136.81, 131.60, 125.47, 124.64, 124.15, 123.20, 120.23, 118.38. Anal. Calcd(%) for C24H20N6O3: C 65.45, H 4.58, N 19.08; found(%): C 65.49, H 4.62, N 19.03. FT-IR (KBr pellet, nu/cm-1): 3344 (m, NH), 1715 (s, CO), 1599 (s, NH). ESI-MS: m/z?=?441 [M+H]+, 463 [M+Na]+.
  • 35
  • [ 52411-34-4 ]
  • [ 15268-31-2 ]
  • C26H24N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% In toluene; acetonitrile; at 60℃; for 3h; General procedure: Isonicotinic acid acyl azide and 1,2-bis(2?-aminophenoxy)ethane were synthesized according to previous literatures [45] and [46], respectively. A solution of isonicotinic acid acyl azide (1.04g, 7.0mmol) in toluene (30mL) was refluxed for 1.5h, and 1,2-bis(2?-aminophenoxy)ethane (0.73g, 3.0mmol) in acetonitrile (50mL) was added dropwise. The reaction mixture was stirred 60C for 3h and then cooled to room temperature. The precipitate that formed was collected by filtration and washed by methanol to give a white solid.
  • 36
  • [ 1159819-32-5 ]
  • [ 15268-31-2 ]
  • [ 2410944-51-1 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 20℃; for 16h; 214 Example 214: 1-(3-Pyridyl)-3-[6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]urea A solution of 6-[4-(trifluoromethyl)phenyl]pyrazin-2-amine (CAS Number 1159819-32-5; 50 mg, 0.21 mmol) and pyridine-3-isocyanate (45 mg, 0.38 mmol) in DCM was shaken at rt for 16 h. The reaction mixture was diluted with MeOH and the resultant solution evaporated. The residual material was suspended in MeOH and the mixture filtered, and the precipitate washed with further aliquots of MeOH. The solid material was transferred to a vial, dried in the vacuum oven to give 1-(3-pyridyl)-3-[6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]urea. m/z ES+ [M+H]+ 360; 1H NMR (600 MHz, DMSO-d6) d 9.86 (s, 1H), 9.64 (s, 1H), 9.14 (d, J = 0.5 Hz, 1H), 8.98 (d, J = 0.5 Hz, 1H), 8.65 (dd, J = 2.6, 0.7 Hz, 1H), 8.34- 8.30 (m, 2H), 8.27 (dd, J = 4.7, 1.5 Hz, 1H), 8.01 (ddd, J = 8.3, 2.6, 1.5 Hz, 1H), 7.97- 7.91 (m, 2H), 7.38 (ddd, J = 8.3, 4.6, 0.7 Hz, 1).
Same Skeleton Products
Historical Records