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Chemical Structure| 154477-54-0 Chemical Structure| 154477-54-0

Structure of 154477-54-0

Chemical Structure| 154477-54-0

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Product Details of [ 154477-54-0 ]

CAS No. :154477-54-0
Formula : C15H19ClO3
M.W : 282.76
SMILES Code : CC(C)(C1=CC=C(C(CCCCl)=O)C=C1)C(OC)=O
MDL No. :MFCD09031254
InChI Key :ULWORPZJUIFPIC-UHFFFAOYSA-N
Pubchem ID :10062338

Safety of [ 154477-54-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 154477-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 154477-54-0 ]
  • Downstream synthetic route of [ 154477-54-0 ]

[ 154477-54-0 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 115-46-8 ]
  • [ 154477-54-0 ]
  • [ 154477-55-1 ]
YieldReaction ConditionsOperation in experiment
80% With potassium hydrogencarbonate; potassium iodide In toluene at 80℃; for 30 h; Reflux 1000 mL reaction flask, 55.4 g of diphenylpiperidine methanol was added successively, 42.1 g of potassium bicarbonate, 3.1g potassium iodide, 310 mL of toluene, Heated to 80 ° C, A solution of methyl 2- (4- (4-chlorobutyryl) phenyl) -2-methylpropanoate (VI) (53.3 g) in toluene (150 ml) was slowly added dropwise, Plus, Reflux reaction about 30h, HPLC monitoring reaction is complete, The reaction solution was cooled to 10 to 15 ° C, filter, The filtrate was concentrated to give 107 g of crude product; With 250mL anhydrous ethanol heated reflux solution, Dropping 80 mL of water, After refluxing for 30 min, Natural cooling to 10 ~ 15 deg C, Insulation stirring 4h, Filtration gave an off-white solid, Drying 90g; And then recrystallized with EA, To obtain 77.4 g of methyl 2- [4- [4- [4- (hydroxydiphenylmethyl) -1-piperidinyl] -butanoyl] phenyl] -2-methylpropionate (VII) as a white solid, Purity 99.5percent Yield 80percent. among them, The molar ratio of methyl 2- (4- (4-chlorobutyryl) phenyl) -2-methylpropanoate (VI), potassium iodide and base is 1: 0.1: 2.23.
References: [1] Patent: CN106380441, 2017, A, . Location in patent: Paragraph 0010; 0051; 0052; 0053; 0054; 0055.
[2] Patent: WO2005/19175, 2005, A1, . Location in patent: Page/Page column 26.
[3] Patent: WO2008/12859, 2008, A2, . Location in patent: Page/Page column 4-5.
[4] Patent: WO2009/136412, 2009, A2, . Location in patent: Page/Page column 8.
[5] Patent: US2010/16599, 2010, A1, . Location in patent: Page/Page column 2.
  • 2
  • [ 115-46-8 ]
  • [ 154477-54-0 ]
  • [ 937009-94-4 ]
  • [ 154477-55-1 ]
References: [1] Patent: WO2007/7347, 2007, A1, . Location in patent: Page/Page column 4-5; 7; 11.
[2] Patent: WO2007/7347, 2007, A1, . Location in patent: Page/Page column 4-5; 8; 11-12.
  • 3
  • [ 154477-54-0 ]
  • [ 154477-55-1 ]
References: [1] Patent: US2013/237709, 2013, A1, .
 

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Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bouveault-Blanc Reduction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Ester Cleavage • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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