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[ CAS No. 4635-59-0 ] {[proInfo.proName]}

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Chemical Structure| 4635-59-0
Chemical Structure| 4635-59-0
Structure of 4635-59-0 * Storage: {[proInfo.prStorage]}

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Product Citations

Product Citations

Shifali Shishodia ; Raymundo Nuñez ; Brayden P. Strohmier , et al. DOI: PubMed ID:

Abstract: PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or tumor promoter. PBRM1 is a tumor promoter in prostate cancer, contributing to migratory and immunosuppressive phenotypes. Selective chemical probes targeting PBRM1 bromodomains are desired to elucidate the association between aberrant PBRM1 chromatin binding and cancer pathogenesis and the contributions of PBRM1 to immunotherapy. Previous PBRM1 inhibitors unselectively bind SMARCA2 and SMARCA4 bromodomains with nanomolar potency. We used our protein-detected NMR screening pipeline to screen 1968 fragments against the second PBRM1 bromodomain, identifying 17 hits with Kd values from 45 μM to >2 mM. Structure–activity relationship studies on the tightest-binding hit resulted in nanomolar inhibitors with selectivity for PBRM1 over SMARCA2 and SMARCA4. These chemical probes inhibit the association of full-length PBRM1 to acetylated histone peptides and selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 100-52-7 ; 123-11-5 ; 1711-06-4 ; 454-89-7 ; ; ; ; ; ; ; ; ; ; ; ; ; 118-92-3 ; 22458-07-7 ; ; ; ; ; 97-96-1 ; ; 89-98-5

Product Details of [ 4635-59-0 ]

CAS No. :4635-59-0 MDL No. :MFCD00000754
Formula : C4H6Cl2O Boiling Point : -
Linear Structure Formula :CH2ClCH2CH2C(O)Cl InChI Key :CDIIZULDSLKBKV-UHFFFAOYSA-N
M.W : 141.00 Pubchem ID :78370
Synonyms :
Chemical Name :4-Chlorobutyryl chloride

Safety of [ 4635-59-0 ]

Signal Word:Danger Class:8,6.1
Precautionary Statements:P501-P261-P210-P271-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405 UN#:2922
Hazard Statements:H331-H314-H227 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 4635-59-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 4635-59-0 ]
  • Downstream synthetic route of [ 4635-59-0 ]

[ 4635-59-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 108-86-1 ]
  • [ 4635-59-0 ]
  • [ 6952-89-2 ]
Reference: [1] Chemische Berichte, 1963, vol. 96, p. 2532 - 2536
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