1593-60-8|N-Hydroxy-4-methylbenzenesulfonamide| Ambeed

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Structure of 1593-60-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size

Price

VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock

{[ item.pr_size ]}

Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

Quality Control of [ 1593-60-8 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 1593-60-8 ]

CAS No. :	1593-60-8
Formula :	C₇H₉NO₃S
M.W :	187.22
SMILES Code :	O=S(C1=CC=C(C)C=C1)(NO)=O
MDL No. :	MFCD11850835
InChI Key :	XMJJPCJUQLGGND-UHFFFAOYSA-N
Pubchem ID :	10081163

Safety of [ 1593-60-8 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H315-H319-H228
Precautionary Statements:	P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:	4.1
UN#:	1325
Packing Group:	Ⅲ

Application In Synthesis of [ 1593-60-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1593-60-8 ]

[ 1593-60-8 ] Synthesis Path-Downstream 1~55

1
[ 98-59-9 ]
[ 1593-60-8 ]

Yield	Reaction Conditions	Operation in experiment
87.5%	With hydroxylamine hydrochloride; magnesium oxide; In tetrahydrofuran; methanol; water; at 20℃;	Hydroxylamine hydrochloride (7.2 g, 86 mmol) was dissolved in methanol (30 ml) and water (20 ml), magnesium oxide (5.1 g, 129 mmol) was added, stirred for 10 minutes, then p-toluenesulfonyl chloride (8 g, 43 mmol) in tetrahydrofuran (300 ml), stirred vigorously at room temperature, and reacted to TLC to monitor the starting material for complete reaction. The extract was filtered through Celite, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give N-hydroxy-4-methylbenzenesulfonamide (7 g, white solid) in 87.5% yield.

References: [1]Patent: CN105418632,2016,A .Location in patent: Paragraph 0175; 0176; 0177.
[2]Synlett,2009,p. 2149 - 2153.
[3]Journal of Inorganic Biochemistry,2013,vol. 118,p. 134 - 139.
[4]Green Chemistry,2021,vol. 23,p. 9428 - 9432.
[5]Journal fur praktische Chemie (Leipzig 1954),1901,vol. <2>63,p. 176.
Chemisches Zentralblatt,1901,vol. 72,p. 455.
[6]European Journal of Medicinal Chemistry,1996,vol. 31,p. 1001 - 1010.
[7]Organometallics,2017,vol. 36,p. 1259 - 1268.
[8]Advanced Synthesis and Catalysis,2019,vol. 361,p. 5552 - 5557.

2
C₂₆H₂₃NO₃S [ No CAS ]
[ 1593-60-8 ]

References: [1]Journal of Organic Chemistry,2007,vol. 72,p. 8123 - 8126.

3
[ 100-42-5 ]
[ 1593-60-8 ]
[ 1377813-85-8 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

4
[ 1073-67-2 ]
[ 1593-60-8 ]
[ 1377813-86-9 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

5
[ 637-69-4 ]
[ 1593-60-8 ]
[ 1377813-95-0 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

6
[ 826-74-4 ]
[ 1593-60-8 ]
[ 1377813-99-4 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

7
[ 6380-23-0 ]
[ 1593-60-8 ]
[ 1377813-97-2 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

8
[ 7315-32-4 ]
[ 1593-60-8 ]
[ 1377813-98-3 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

9
[ 100-13-0 ]
[ 1593-60-8 ]
[ 1377813-94-9 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

10
[ 405-99-2 ]
[ 1593-60-8 ]
[ 1377813-90-5 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

11
[ 2039-82-9 ]
[ 1593-60-8 ]
[ 1377813-89-2 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

12
[ 3435-51-6 ]
[ 1593-60-8 ]
[ 1377813-93-8 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

13
[ 402-50-6 ]
[ 1593-60-8 ]
[ 1377813-92-7 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

14
[ 394-46-7 ]
[ 1593-60-8 ]
[ 1377813-91-6 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

15
[ 2039-85-2 ]
[ 1593-60-8 ]
[ 1377813-87-0 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

16
[ 2039-87-4 ]
[ 1593-60-8 ]
[ 1377813-88-1 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

17
[ 1593-60-8 ]
[ 768-03-6 ]
[ 1377814-01-1 ]

References: [1]European Journal of Organic Chemistry,2012,p. 2711 - 2714.

18
[ 1262863-78-4 ]
[ 1593-60-8 ]
N-hydroxy-4-methyl-N-[3-phenyl-1-(1-tosyl-1H-indol-3-yl)prop-2-ynyl]benzenesulfonamide [ No CAS ]

References: [1]European Journal of Organic Chemistry,2012,p. 5767 - 5773.

19
[ 1369593-22-5 ]
[ 1593-60-8 ]
N-hydroxy-N-[1-(4-methoxyphenyl)hex-2-ynyl]-4-methylbenzenesulfonamide [ No CAS ]

References: [1]European Journal of Organic Chemistry,2012,p. 5767 - 5773.

20
[ 1593-60-8 ]
1-phenylnon-2-yn-1-ol [ No CAS ]
N-hydroxy-4-methyl-N-(1-phenylnon-2-ynyl)benzenesulfonamide [ No CAS ]

References: [1]European Journal of Organic Chemistry,2012,p. 5767 - 5773.

21
[ 1817-49-8 ]
[ 1593-60-8 ]
[ 1415035-26-5 ]

Yield	Reaction Conditions	Operation in experiment
38%	With iodine; In dichloromethane; water; at 25℃; for 3h;	General procedure: To a solution of propargyl alcohol 1 (0.6 mmol) and N-tosyl hydroxylamine 2 (0.5 mmol) in wet DCM (5 mL) was added I2 (1.0 mmol) slowly at 25 C, and the reaction mixture was stirred at a shown temperature for an indicated period of time shown in text. Saturated aqueous Na2S2O3 was added to quench the reaction and the mixture was extracted with DCM. The organic layer was washed with brine and dried over Na2SO4, filtered and concentrated. The residue was purified flash column chromatography on silica gel with DCM/hexane as eluent to give 4 or 5.400.0971.

References: [1]European Journal of Organic Chemistry,2012,p. 5767 - 5773.
[2]Tetrahedron,2012,vol. 68,p. 10194 - 10200,7.

22
[ 1593-60-8 ]
[ 73502-43-9 ]
[ 1415035-11-8 ]

Yield	Reaction Conditions	Operation in experiment
46%	With ytterbium(III) triflate; In dichloromethane; at 25℃; for 2h;	General procedure: To a solution of propargyl alcohol 1 (0.6 mmol) and N-tosyl hydroxylamine 2 (0.5 mmol) in dry DCM (5 mL) was added Yb(OTf)3 (0.05 mmol) slowly at 25 C, and the reaction mixture was stirred at the shown temperature for an indicated period of time shown in text. Saturated aqueous brine was added to quench the reaction and the mixture was extracted with DCM. The organic layer was washed with brine and dried over Na2SO4, filtered and concentrated. The residue was purified by flash column chromatography on silica gel with DCM/hexane as eluent to give 3.