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Structure of 16182-04-0
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CAS No. : | 16182-04-0 |
Formula : | C4H5NO2S |
M.W : | 131.15 |
SMILES Code : | O=C(N=C=S)OCC |
MDL No. : | MFCD00004814 |
InChI Key : | BDTDECDAHYOJRO-UHFFFAOYSA-N |
Pubchem ID : | 85320 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H226-H315-H317-H319-H331-H334-H335 |
Precautionary Statements: | P210-P233-P240-P241-P242-P243-P261-P264-P271-P272-P280-P284-P303+P361+P353-P304+P340+P311-P305+P351+P338-P333+P313-P337+P313-P342+P311-P370+P378-P403+P233-P403+P235-P405-P501 |
Class: | 6.1(3) |
UN#: | 2929 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91.1% | Stage #1: at 78℃; for 5.33333 h; Heating / reflux Stage #2: With hydroxyammonium sulfate In water; ethyl acetate at 71℃; Heating / reflux Stage #3: With sodium carbonate In water; ethyl acetate at 71℃; for 7 h; Heating / reflux |
One pot procedure for the synthesis of 2-amino-5,7-dimethoxy [1,2, 4] triazolopyrimidine (ADTP) from 2-amino-4,6-dimethoxypyrimidine (ADP) 11. 9 g (0.075 mol) ADP was dissolved in 68 g ethyl acetate. 11 g (0.0825 mol) ethoxycarbonyl isothiocyanate was added within 20 min. at 78°C (no exotherm). The mixture was stirred over 5 h at reflux (78-79°C). 49.2 g (0.075 mol) hydroxylammonium sulfate (25 percent solution in water) were added and the mixture heated to 71°C (reflux aceotrope). 50 g (0.1 mol) diluted caustic soda (2 mot/1) was added within 1 h to establish the pH from 1.3 to 6.5 and hold at 6.5-7. 0 (offgas C02 and H2S, slightly exotherm). The mixture was stirred over 6 h under reflux (71°C) for reaction completion. The mixture was cooled down over night to 20°C. The product (ADTP) was filtrated and washed 3 times with each 25 g water to remove the salt (Na content after first wash 0.42 percent, after second 0.20 percent, after third 0.025 percent). Finally the solid ADTP was dried. Yield : 91.1 percent in respect to ADP, purity 95.3 percent (quantitative HPLC assay). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70.4% | Stage #1: at 27 - 87℃; Stage #2: at 40℃; Stage #3: With hydroxylamine In water; toluene at 68 - 81℃; |
Example 4 Preparation of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine (Ia) To a 700 mL jacketed vessel equipped with a mechanical stirrer, a dual pH/temperature probe, a nitrogen inlet, and a reflux condenser was added sequentially 27.9 g (0.180 mol) of 4-amino-2,5-dimethoxypyrimidine followed by 165.4 g (0.207 mol) of 16.4 wt percent ethoxy carbonylisothiocyanate solution in toluene. The reaction mixture was heated to gentle reflux (87 ° C.) for 7 h at which time liquid chromatographic (LC) analysis indicated ˜95percent conversion of starting 4-amino-2,5-dimethoxypyrimidine. The reaction mixture was cooled to 27 ° C. and allowed to stand overnight. The mixture was heated to 40° C. and then 114.2 g (6.34 mol) of deionized water was added to the mixture. After heating to reflux (˜68° C.). , 14.3 g (0.217 mol) of a 50 wt percent aqueous hydroxylamine solution was continuously added over a 2 h 15 min period via a peristaltic pump. During the course of the amine addition, the reaction pH rose from 4.44 to 6.95. After complete addition of hydroxylamine, the pump line was flushed with 4.8 g (0.266 mol) of deionized water, the reaction mixture was heated to 81° C., and then stirred an additional 3 h during which time the reaction pH naturally raised to 7.40. The reaction mixture was cooled to ambient temperature (26° C.). The reaction mixture was then suction transferred into a temporary holding vessel. The reactor was washed with two 30 g portions of water. These water washes were combined with the reaction mixture. The combined mixture was suctioned filtered through a coarse Buchner funnel (filtration time about 30 seconds), and the filtrate was collected and filtered a second time through the cake. A final displacement cake wash with ˜40 g of methanol was performed and the product was dried at 60° C. under vacuum (˜<10 mm Hg; 1333 Pa) to afford 25.37 g of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine as a light cream colored solid. NMR analysis (using benzyl acetate as an internal standard) indicated an 97.3percent purity of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine active which corresponds to a 70.4percent yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | In dichloromethane; at 20℃; for 3h; | A mixture of 3-fluoro-2-methyl-aniline (10.0 g, 80.0 mmol),ethoxycarbonyl thioisocyanate (10.48 g, 80.0 mmol), dichloromethane(400 mL) was stirred at room temperature for 3 hours. At the end, reaction mixture was concentrated and the separated solid was washed with hexanes, dried to give ethyl [(3-fluoro-2- methylphenyl)amino]carbonothioyl}carbamate 15.0 g (76percentyield). MS(ESI) m/z 257.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | In dichloromethane; at 20℃; | To a solution of <strong>[885270-30-4]1-Boc-4-aminoindole</strong> (5.23 g, 22.5 mmol) in CH2Cl2 was added ethyl isothiocyanatoformate (2.95 g, 22.5 mmol), and the resulting mixture was stirred at room temperature for 2 h. The mixture was concentrated under reduced pressure and triturated with diethyl ether to give the title compound as off-white solid (8.1 g, 99% yield). |
89.4% | In toluene; at 20 - 28℃; for 1.0h;Product distribution / selectivity; | Step 3: Preparation of tert-butyl 4-(3-ethoxycarbonyl)thioureido)-1H-indole-1-carboxylate (4) To a 3 L four-necked flask equipped with a mechanical stirrer, thermocouple, and N2 inlet tube was added tert-butyl 4-amino-1H-indole-1-carboxylate (121.0 g, 0.521 mole) and toluene (1100 mL). The reaction mixture was stirred at room temperature and a clear solution was formed. To this clear solution, ethyl isothiocyanatoformate (68.3 g, 0.52 mole, 1.0 eq) was added over one hour period keeping internal temperature between 20-28 C. The product precipitated during the addition. HPLC analysis showed the reaction was complete at the end of the addition. The product was filtered off and washed with 1:1 toluene:heptane (800 ml) to give 169.0 g light yellow product in 89.4% yield (100% pure by analytical HPLC) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | at 20℃; | Step A: 5-Methoxypyridin-2-amine ethoxycarbonyl thiourea To 5-methoxypyridin-2-amine (5 g, 40 mmol) in dioxane (40 mL) was added ethoxycarbonyl isothiocyanate (5.23 mL, 44.3 mmol). The reaction mixture was stirred at room temperature overnight. The mixture was concentrated in vacuo to afford 5-methoxypyridin-2-amine ethoxycarbonyl thiourea (10.28 g, 40.3 mmol, 100percent yield). 1H NMR (300 MHz, DMSO-d6) delta ppm 12.03 (1H, br. s.), 11.37 (1H, br. s.), 8.53 (1H, br. s.), 8.11 (1H, d, J=2.93 Hz), 7.50 (1H, dd, J=8.97, 3.11 Hz), 4.22 (2H, q, J=7.07 Hz), 3.84 (3H, s), 1.26 (3H, t, J=7.14 Hz). MS (LC/MS) R.T.=2.40; [M+H]+=256.1. |
100% | at 20℃; | To 5-methoxypyridin-2-amine (5 g, 40 mmol) indioxane (40 mL) was added ethoxycarbonyl isothiocyanate(5.23 ml., 44.3 mmo1). The reaction mixture was stirred atroom temperature overnight. The mixture was concentratedin vacuo to afford 5-methoxypyridin-2-amine ethoxycarbonylthiourea(10.28 g, 40.3 mmol, 100percent yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | In dimethyl sulfoxide; for 15h; | To a solution of 5-methoxypyridin-2-amine (1.05 g, 8.43 mmol) in dimethyl sulfoxide (5 mL) was added ethyl isothiocyanatoformate (1.44 g, 11.0 mmol), and the mixture was stirred for 15 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (*3) . The combined organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the residue was dried to give the title compound (1.34 g, 62percent) as a white solid. 1H-NMR (DMSOd5, 300 MHz) delta 1.26 (3H, t, J = 7.2 Hz), 3.84 (3H, s), 4.22 (2H, q, J = 7.2 Hz), 7.51 (IH, dd, J = 9.0, 3.0 Hz), 8.12 (IH, d, J = 3.0 Hz), 8.54 (IH, br s) , 11.38 (IH, br s), 12.04 (IH, br s) . |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In 1,4-dioxane; at 20℃; | Step A: 5-Methoxypyridin-2-amine ethoxycarbonyl thioureaTo 5-methoxypyridin-2-amine (5g, 40 mmol) in dioxane (40 mL) was added ethoxycarbonyl isothiocyanate (5.23 mL, 44.3 mmol). The reaction mixture was stirred at room temperature overnight. The mixture was concentrated in vacuo to afford 5-methoxypyridin-2-amine ethoxycarbonyl thiourea (10.28 g, 40.3 mmol, 100 percent yield). XH NMR (300 MHz, DMSO-i/6) delta ppm 12.03 (1 H, br. s.), 11.37 (1 H, br. s.), 8.53 (1 H, br. s.), 8.11 (1 H, d, J=2.93 Hz), 7.50 (1 H, dd, J=8.97, 3.11 Hz), 4.22 (2 H, q, J=7.07 Hz), 3.84 (3 H, s), 1.26 (3 H, t, J=7.14 Hz). MS (LC/MS) R.T. = 2.40; [M+H]+ = 256.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In water; toluene; at 25℃; for 1.33333h; | To a solution of <strong>[538-28-3]S-(benzyl)isothiourea hydrochloride</strong> (203 mg, 1.00 mmol) in H2O (3 mL), toluene (5 mL) was added and the mixture stirred vigorously. After 5 min, ethoxycarbonyl isothiocyanate (184 mg, 1.40 mmol) in toluene (2 mL) and NaOH (2 M, 4 mL) were simultaneously added over a period of 5 min. Additional NaOH (2 M, 2 mL) was added after 15 min and then the reaction mixture was stirred for 1 h at room temperature. The phases were then separated and the organic layer washed with NaOH (2 M, 6 mL). The combined alkaline phases were acidified to pH 1 with H2SO4, and in this way the precipitate was formed, which was then filtered off and crystallized from CH3CN. Spectroscopic data (without 13C NMR spectra) for this compound are described in Ref. [25]. 13C NMR (100 MHz, DMSO-d6): delta 33.62, 127.55, 128.53, 129.17, 136.14, 149.70, 168.15 (br s), 178.46 (br s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | In N,N-dimethyl-formamide; at 20℃; for 5h; | Synthesis of N-carbethoxy-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea (17). To the solution of<strong>[4922-98-9]3-phenyl-1,2,4-triazol-5-amine</strong> (12, 0.48 g, 3 mmol) in anhydrous DMF (4 mL), ethoxycarbonylisothiocyanate (0.43 mL, 3.3 mmol) was added. After stirring the mixture for 5 h at room temperature,cold water (60 mL) was added. The precipitated product was filtered, washed with cold water andrecrystalized from EtOH. Yield 0.74 g, 85%; mp 180-181 C (EtOH). 1H-NMR (300 MHz, DMSO-d6): 1.28 (3H, t, J = 7.1 Hz, CH3), 4.25 (2H, q, J = 7.1 Hz, CH2), 7.37-7.66 (3H, m, H-30, H-40 and H-50), 8.01(2H, d, J = 7.2 Hz, H-20 and H-60), 11.56* (12H, brs, 2NH), 11.87 (1H, brs, NH), 12.16 (1H, brs, NH), 13.93(1H, brs, N(1)H), 14.47 (1H, brs, N(1)H)*. *-signals of the minor tautomer. Combustion elementalanalysis calculated for C12H13N5O2S: C, 49.47; H, 4.50; N, 24.04. Found: C, 49.33; H, 4.62; N, 23.95. |
In N,N-dimethyl-formamide; at 20℃; for 5h; | General procedure: Initially, amidoguanidines (7) were prepared via the reaction of substituted benzoyl chloride (5) (10 mmol) and aminoguanidine hydrochloride (6) (20 mmol). The obtained intermediates (7) were then treated with microwave irradiation power (100 W) for 8-15 min in water to generate 5-amino-1,2,4-triazoles (8) [18] . Subsequently, 5-amino-1,2,4-triazoles (8) (3 mmol) were reacted with ethoxycarbonyl isothiocyanate (3.3 mmol) in anhydrous DMF (4 ml) at room temperature, leading to formation of thiourea derivatives (9). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | In acetone; for 0.25h;Cooling with ice; | Synthesis of 5-amino-1-carbethoxythiocarbamoyl-1,2,4-triazole (16). To a solution of acetone(30 mL), <strong>[4922-98-9]3-phenyl-1,2,4-triazol-5-amine</strong> (12, 3.20 g, 20 mmol) and ethoxycarbonyl isothiocyanate(2.62 mL, 20 mmol) were added. The reaction mixture was stirred on an ice-bath for 15 min. The yellowprecipitate formed was filtered immediately. Yield 2.16 g, 37%; mp 207-209 C. 1H-NMR (300 MHz,DMSO-d6): 2.63 (3H, s, SMe), 7.47-7.57 (3H, m, H-30, H-40 and H-50), 8.03 (2H, dd, J = 6.8, 3.0 Hz,H-20 and H-60), 8.64 (2H, s, NH2). 13C-NMR (75 MHz, DMSO-d6): 18.8, 126.6 (2C), 128.8 (2C), 129.1,130.6, 157.5, 158.8, 199.5. Combustion elemental analysis calculated for C12H13N5O2S: C, 49.47; H, 4.50;N, 24.04. Found: C, 49.20; H, 4.67; N, 23.88. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71.42% | 13.1 5-chloro-[1 ,2,4]triazolo[1 ,5-a]pyrazin-2-ylamine To a solution of <strong>[33332-28-4]2-amino-6-chloropyrazine</strong> (15.0 g, 115.8 mmol) in dry tetrahydrofuran (150 ml), ethoxycarbonylisothiocyante (16.7g, 127.4 mmol) is added and heated to 50°C for 12 hours. The reaction mixture is concentrated and suspended in ethanol/methanol (1:1 , 300 ml), hydroxylamine hydrochloride (40.09 g, 576.9 mmol) and diisopropylethylamine (44.73 g, 346.1 mmol) are added and heated to 80°C for 3 hours. The reaction mixture is concentrated and the crude mass is taken in water and filtered, washed with water, cold acetonitrile, diethylether, to get the product as pale yellow solid (14.0 g, 71.42 percent); TLC: chloroform/methanol (9.5/0.5) Rf- 0.2. 1H NMR: 400 MHz, DMSO-d6: delta [ppm] 8.80 (s, 1H), 8.18 (s, 1 H), 6.75 (br s, 2H); LCMS: Mass found (M+, 170.0) Method: A-0.1percent TFA in H20, B-0.1percent TFA in ACN: Flow - 1.0 ml/min. Column: XBridge C8 (50 X 4.6 mm, 3.5 pm), +ve mode Rt (min): 2.01 area percent -99.66 (Max), 99.51 (220 nm); HPLC Method: A- A-0.1percent TFA in H20, B- percent TFA in ACN: Flow - 1.0ml/min. Column: XBridge C8 (50 X 4.6 mm, 3.5 pm) Rt (min): 2.02 area percent - 99.23 (Max), 99.05 (220nm). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; at 20℃; for 1.0h; | General procedure: To a fine suspension of 1 mmol of the corresponding amine in 3 ml of anhydrous DMF was added 1 mmol of ethoxycarbonylisothiocyanate. After stirring the mixture for 1 h at room temperature, 30 ml of cold water was added. The precipitated product was filtered, washed with cold water and recrystallized from ethanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96.73% | In 1,4-dioxane; at 25℃; for 18h; | e) Ethyl-N-[(3,6-dimethylpyrazin-2-yl)carbamothioyl]carbamate To a solution of 3, 6-dimethyl-pyrazin-2-ylamine (5 g, 40.65 mmol) in dioxane (150ml) was added ethoxycarbonyl isothiocyanate (4.75 ml, 40.65 mmol) at 25 C, and the reaction mixture was stirred for 18 hours at 25 C. Volatiles were removed in vacuo. The resultant residue was dissolved in ethyl acetate, washed with water twice, and brine, dried over anhydrous sodium sulfate, filtered, and evaporated affording ethyl-N-[(3,6-dimethylpyrazin-2- yl)carbamothioyl] carbamate (10 g, 96.73%) as a light yellow solid. MS: m/z= 255 (M+H+) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; at 20℃; | General procedure: To a solution of methyl-3-amino-5-p-tolylthiophene-2-carboxylate in DMF (40 mL) was added ethoxycarbonyle isothiocyanate(1 eq). The solution was left stirring at room temperature overnight. During this reaction, a thiourea carbamate intermediate was formed and was not isolated. To the reaction mixture were then added triethylamine (3 eq), terbutylamine (2 eq) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, hydrochloride (EDCI,HCl) (1.2 eq). The solution was then heated under reflux for 2 h. The solvent was removed under reduced pressure. Water (10 mL) was then added to the reaction mixture and the precipitated solid obtained was filtered, washed with diethyl ether and recrystallized from acetonitrile to give the corresponding 2-alkyl(dialkyl)aryl-2-aminothieno[3,2-d]pyrimidin-4(3H)-one derivative. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: Typical procedure exemplified by the synthesis of 2-amino-4-chlorobenzo-1-thiophene-3-carbonitrile (Table 1, entry 5a): To a N2 flushed, 500 mL, three necked round bottomed flask were added <strong>[75279-55-9]2-chloro-6-fluorophenylacetonitrile</strong> (1e) (8.48 g, 50 mmol) and DMSO (100 mL). To the solution was added 60% sodium hydride (2.10 g, 52.5 mmol) portion wise under N2 at rt (slightly exothermic). After 30 min, the reaction mixture was cooled to 15C with cold water bath and O-ethyl carbonisothiocyanatidate (2) (5.65 mL, 50.0 mmol) was added drop wise. After 1 h, the reaction mixture was heated at 100C for 2 h. A solution of 5 N NaOH (50 mL) was added and the reaction mixture was stirred at 100C for 2 h. The suspension was cooled to rt with stirring and 700 mL of water was added. The mixture was then cooled to 15C. The suspension was filtered and house vacuum air dried for 18 h to give the crude product as ayellow solid (6.5 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile; at 0 - 20℃; for 2.16667h;Inert atmosphere; | General procedure: Ethyl 2-amino-1H-pyrrole-3-carboxylate 13 (21.8 g, 141.5 mmol, 1.00 eq) was dissolved in anhydrous acetonitrile (300 ml, dried over CaH) and the mixture was cooled to 0C under inert atmosphere. Ethoxycarbonyl isothiocyanate 6 (18.8 g, 143.3 mmol, 1.01 eq) was added dropwise over 10 minutes after which the mixture was warmed to room temperature. After two hours, the reaction mixture was concentrated in vacuo and the residue was dissolved in CH2Cl2 (1.5 l). Precipitating solids were removed via filtration and the filtrate was washed with brine (1 x 500 ml, 1 x 300 ml), dried (MgSO4), filtered and the filtrate was concentrated in vacuo to afford the title compound 23, which was used as such without purification due to poor solubility. 83% yield (33.5 g, crude), red solid. Rf: (PE/EtOAc 8/1) 0.10, MP: 109C, IR: (ATR) nu 3160, 2981, 1704, 1677 cm-1. 1H NMR (250 MHz, CDCl3): delta 13.36 (br. s, 1H), 12.02 (br. s, 1H), 8.04 (br. s, 1H), 6.51 (d, J = 2.7 Hz, 2H), 4.41 - 4.29 (m, 4H), 1.39 - 1.28 ppm (m, 6H). 13C DEPT NMR (125 MHz, CDCl3): delta 112.39, 107.42, 63.41, 59.93, 14.68, 14.67 ppm. |
Tags: 16182-04-0 synthesis path| 16182-04-0 SDS| 16182-04-0 COA| 16182-04-0 purity| 16182-04-0 application| 16182-04-0 NMR| 16182-04-0 COA| 16182-04-0 structure
Precautionary Statements-General | |
Code | Phrase |
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P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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