Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 165806-95-1 Chemical Structure| 165806-95-1

Structure of 165806-95-1

Chemical Structure| 165806-95-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 165806-95-1 ]

CAS No. :165806-95-1
Formula : C15H12FNO2S
M.W : 289.33
SMILES Code : FC1=CC=C(C=C1)C([N+]#[C-])S(=O)(C2=CC=C(C)C=C2)=O
MDL No. :MFCD03787932
InChI Key :UXCQPEDHCCJBNL-UHFFFAOYSA-N
Pubchem ID :10827289

Safety of [ 165806-95-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 165806-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 165806-95-1 ]

[ 165806-95-1 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 118289-17-1 ]
  • [ 74-89-5 ]
  • [ 165806-95-1 ]
  • [ 1375501-80-6 ]
YieldReaction ConditionsOperation in experiment
Example 50: Synthesis of {4-[5-(4-Fluoro-phenyl)-3-methyl-3H-imidazol-4-yl]-pyridin-2- yl}-ureaStep 1: Synthesis of 2-Bromo-4-[5-(4-fluoro-phenyl)-3-methyl-3H-imidazol-4-yl]-pyridine2-Bromo-pyridine-4-carbaldehyde (479 mg, 2.58 mmol) and 2.0 M methylamine THF solution (1.73 mL, 3.46 mmol) are mixed in THF (6.0 mL) and the reaction mixture is stirred for 4 hrs at room temperature. Then piperazine (224 mg, 2.58 mmol) and [l-(4-fluorophenyl)-l- tosyljmethylisocyanide (500 mg, 1.73 mmol) are added. The reaction mixture is stirred for another 16 hrs before water (35 mL) is added. The resulting mixture is extracted with EtOAc (3 x 35 mL) and the organic layers are combined, washed with saturated NaHCC>3 aqueous solution (20 ml) and water (25 mL), dried and concentrated to give the crude product. Purification by silica flash column chromatography using EtOAc in heptane (gradient from 20percent to 90percent) affords 460 mg of desired product.
  • 2
  • [ 118289-17-1 ]
  • [ 165806-95-1 ]
  • [ 1375501-95-3 ]
YieldReaction ConditionsOperation in experiment
With piperazine; ammonium hydroxide; In tetrahydrofuran; water; at 20℃; for 16h; Example 54: Synthesis of {4-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-pyridin-2-yl}-ureaStep 1: Synthesis of 2-Bromo-4-[4-(4-fluoro-phenyl)-oxazol-5-yl]-pyridine2-Bromo-pyridine-4-carbaldehyde (958 mg, 5.15 mmol), 28percent aqueous ammonium hydroxide solution (2.01 mL, 15.5 mmol), piperazine (448 mg, 5.15 mmol) and [l-(4-fluorophenyl)-l- tosyljmethylisocyanide (1.0 g, 3.5 mmol) are mixed in THF (15 mL). The reaction mixture is stirred for 16 hrs at room temperature. Then water (35 mL) is added and the mixture is extracted with EtOAc (3 x 25 mL). The organic layers are combined, washed with saturated NaHCC>3 aqueous solution (20 mL) and water (25 mL), dried and concentrated to give the crude product. Purification by silica flash column chromatography using EtOAc in heptane (gradient from 10percent to 80percent) affords 748 mg of desired product.
  • 3
  • [ 728034-12-6 ]
  • [ 66247-84-5 ]
  • [ 165806-95-1 ]
  • 4-(1-((1H-imidazol-4-yl)methyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% General procedure: To a solutionof the corresponding aldehyde (1.2 eq.; unless stated otherwise) in DMF (2 inL per 0.3 mmol of aldehyde; unless stated otherwise) was added the corresponding amine (2.5 eq.; unless stated otherwise) and the resulting solution was stirred at 25 C to form the corresponding inline. Then, the corresponding isocyano(tosyl)methyl)arene reagent (1 eq.; unless stated otherwise) and K2CO3 (1.5 eq.; unless stated otherwise*) were added and the reaction mixture was stirred at 25 C (unless stated otherwise). The reaction was stopped after the time indicated for each particular reaction. The reaction progress was monitored by TLC. (0083) A saturated aqueous solution of NH4CI (10 mL per 1 mmol of aldehyde) was added to the reaction mixture, which was then extracted with EtOAc (2 x 30 mL per 1 mmol of aldehyde). The combined organic extracts were washed with H2O (2 x 25 mL per 1 mmol of aldehyde), dried over MgSCC, filtered, and the solvent was evaporated in vacuo to provide the crude product. The residue obtained after the workup was purified using column chromatography or preparative TLC (unless stated otherwise). (0084) * note: in cases when the amine was used as HC1 salt, 4 eq. of K2CO3 were used
  • 4
  • [ 728034-12-6 ]
  • [ 165806-95-1 ]
  • [ 63139-97-9 ]
  • 5-((4-(4-fluorophenyl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-imidazol-1-yl)methyl)-2-methylthiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
14% General procedure: To a solutionof the corresponding aldehyde (1.2 eq.; unless stated otherwise) in DMF (2 inL per 0.3 mmol of aldehyde; unless stated otherwise) was added the corresponding amine (2.5 eq.; unless stated otherwise) and the resulting solution was stirred at 25 C to form the corresponding inline. Then, the corresponding isocyano(tosyl)methyl)arene reagent (1 eq.; unless stated otherwise) and K2CO3 (1.5 eq.; unless stated otherwise*) were added and the reaction mixture was stirred at 25 C (unless stated otherwise). The reaction was stopped after the time indicated for each particular reaction. The reaction progress was monitored by TLC. (0083) A saturated aqueous solution of NH4CI (10 mL per 1 mmol of aldehyde) was added to the reaction mixture, which was then extracted with EtOAc (2 x 30 mL per 1 mmol of aldehyde). The combined organic extracts were washed with H2O (2 x 25 mL per 1 mmol of aldehyde), dried over MgSCC, filtered, and the solvent was evaporated in vacuo to provide the crude product. The residue obtained after the workup was purified using column chromatography or preparative TLC (unless stated otherwise). (0084) * note: in cases when the amine was used as HC1 salt, 4 eq. of K2CO3 were used
  • 5
  • [ 728034-12-6 ]
  • [ 22600-77-7 ]
  • [ 165806-95-1 ]
  • 4-(1-((1H-imidazol-2-yl)methyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
10% General procedure: To a solutionof the corresponding aldehyde (1.2 eq.; unless stated otherwise) in DMF (2 inL per 0.3 mmol of aldehyde; unless stated otherwise) was added the corresponding amine (2.5 eq.; unless stated otherwise) and the resulting solution was stirred at 25 C to form the corresponding inline. Then, the corresponding isocyano(tosyl)methyl)arene reagent (1 eq.; unless stated otherwise) and K2CO3 (1.5 eq.; unless stated otherwise*) were added and the reaction mixture was stirred at 25 C (unless stated otherwise). The reaction was stopped after the time indicated for each particular reaction. The reaction progress was monitored by TLC. (0083) A saturated aqueous solution of NH4CI (10 mL per 1 mmol of aldehyde) was added to the reaction mixture, which was then extracted with EtOAc (2 x 30 mL per 1 mmol of aldehyde). The combined organic extracts were washed with H2O (2 x 25 mL per 1 mmol of aldehyde), dried over MgSCC, filtered, and the solvent was evaporated in vacuo to provide the crude product. The residue obtained after the workup was purified using column chromatography or preparative TLC (unless stated otherwise). (0084) * note: in cases when the amine was used as HC1 salt, 4 eq. of K2CO3 were used
  • 6
  • [ 88675-24-5 ]
  • [ 728034-12-6 ]
  • [ 165806-95-1 ]
  • 4-(4-(4-fluorophenyl)-1-(tetrahydrofuran-3-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
13% General procedure: To a solutionof the corresponding aldehyde (1.2 eq.; unless stated otherwise) in DMF (2 inL per 0.3 mmol of aldehyde; unless stated otherwise) was added the corresponding amine (2.5 eq.; unless stated otherwise) and the resulting solution was stirred at 25 C to form the corresponding inline. Then, the corresponding isocyano(tosyl)methyl)arene reagent (1 eq.; unless stated otherwise) and K2CO3 (1.5 eq.; unless stated otherwise*) were added and the reaction mixture was stirred at 25 C (unless stated otherwise). The reaction was stopped after the time indicated for each particular reaction. The reaction progress was monitored by TLC. (0083) A saturated aqueous solution of NH4CI (10 mL per 1 mmol of aldehyde) was added to the reaction mixture, which was then extracted with EtOAc (2 x 30 mL per 1 mmol of aldehyde). The combined organic extracts were washed with H2O (2 x 25 mL per 1 mmol of aldehyde), dried over MgSCC, filtered, and the solvent was evaporated in vacuo to provide the crude product. The residue obtained after the workup was purified using column chromatography or preparative TLC (unless stated otherwise). (0084) * note: in cases when the amine was used as HC1 salt, 4 eq. of K2CO3 were used
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 165806-95-1 ]

Fluorinated Building Blocks

Chemical Structure| 1147557-74-1

A307233 [1147557-74-1]

2,6-Difluoro-4-(methylsulfonyl)aniline

Similarity: 0.57

Chemical Structure| 383-29-9

A383021 [383-29-9]

4,4'-Sulfonylbis(fluorobenzene)

Similarity: 0.57

Chemical Structure| 657-46-5

A314268 [657-46-5]

1-Fluoro-3-(methylsulfonyl)benzene

Similarity: 0.56

Chemical Structure| 424792-57-4

A351911 [424792-57-4]

1,2-Difluoro-4-(methylsulfonyl)benzene

Similarity: 0.54

Aryls

Chemical Structure| 1330529-37-7

A102237 [1330529-37-7]

1-((Isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene

Similarity: 0.91

Chemical Structure| 36635-61-7

A261697 [36635-61-7]

1-((Isocyanomethyl)sulfonyl)-4-methylbenzene

Similarity: 0.68

Chemical Structure| 1212202-62-4

A372315 [1212202-62-4]

(S)-1-(4-(Methylsulfonyl)phenyl)ethanamine hydrochloride

Similarity: 0.59

Chemical Structure| 1147557-74-1

A307233 [1147557-74-1]

2,6-Difluoro-4-(methylsulfonyl)aniline

Similarity: 0.57

Chemical Structure| 383-29-9

A383021 [383-29-9]

4,4'-Sulfonylbis(fluorobenzene)

Similarity: 0.57

Sulfones

Chemical Structure| 1330529-37-7

A102237 [1330529-37-7]

1-((Isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene

Similarity: 0.91

Chemical Structure| 36635-61-7

A261697 [36635-61-7]

1-((Isocyanomethyl)sulfonyl)-4-methylbenzene

Similarity: 0.68

Chemical Structure| 1212202-62-4

A372315 [1212202-62-4]

(S)-1-(4-(Methylsulfonyl)phenyl)ethanamine hydrochloride

Similarity: 0.59

Chemical Structure| 1147557-74-1

A307233 [1147557-74-1]

2,6-Difluoro-4-(methylsulfonyl)aniline

Similarity: 0.57

Chemical Structure| 383-29-9

A383021 [383-29-9]

4,4'-Sulfonylbis(fluorobenzene)

Similarity: 0.57

Isocyanides

Chemical Structure| 1330529-37-7

A102237 [1330529-37-7]

1-((Isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene

Similarity: 0.91

Chemical Structure| 36635-61-7

A261697 [36635-61-7]

1-((Isocyanomethyl)sulfonyl)-4-methylbenzene

Similarity: 0.68