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Chemical Structure| 16606-55-6

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Product Details of [ 16606-55-6 ]

CAS No. :16606-55-6
Formula : C4H6O3
M.W : 102.09
SMILES Code : O=C1OC[C@@H](C)O1
MDL No. :MFCD00798265
InChI Key :RUOJZAUFBMNUDX-GSVOUGTGSA-N
Pubchem ID :641813

Safety of [ 16606-55-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Computational Chemistry of [ 16606-55-6 ] Show Less

Physicochemical Properties

Num. heavy atoms 7
Num. arom. heavy atoms 0
Fraction Csp3 0.75
Num. rotatable bonds 0
Num. H-bond acceptors 3.0
Num. H-bond donors 0.0
Molar Refractivity 21.99
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

35.53 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.25
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

-0.41
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

0.54
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

-0.38
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

0.84
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

0.37

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-0.21
Solubility 62.3 mg/ml ; 0.61 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

0.13
Solubility 137.0 mg/ml ; 1.34 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Highly soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-0.16
Solubility 70.5 mg/ml ; 0.69 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-7.21 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

2.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

0.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

2.2

Application In Synthesis of [ 16606-55-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 16606-55-6 ]

[ 16606-55-6 ] Synthesis Path-Upstream   1~13

  • 1
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  • [ 105-58-8 ]
  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
90% at 105 - 110℃; for 8 h; Large scale R - Preparation of propylene carbonate,R-1,2-propanediol was added to a glass-lined reactor(38.05 kg, 500Mol),Diethyl carbonate(70.88 kg, 600 mol) and (3.4 kg, 50 mol) of sodium ethoxide,Heated to 105-110 ° C,Reaction for 8 hours,The reaction is terminated,The unreacted diethyl carbonate was distilled off under reduced pressure,Cooled to room temperature,Filter insoluble matter,The filtrate was evaporated to remove the solvent of product R - propylene carbonate 34.24 kg,Purity ≥ 99percentThe yield was 90percent.
81.2% With sodium methylate In ethanol at 80℃; Example 1
Preparation of (R)-4-methyl-1,3-dioxolan-2-one
To the mixture of diethyl carbonate (380 ml, 15.1 mol) and 200 g of (R)-1,2-propanediol was added 40 ml of denatured ethanol (the solution of 9 g sodium methoxide dissolved in 50 ml of anhydrous ethanol), the resulting solution was heated to 80° C., then ethanol was distilled off slowly.
The reaction process was monitored by TLC, after TLC showed that only trace amount of (R)-1,2-propanediol remained or (R)-1,2-propanediol was undetectable, ethanol was distilled under vacuum by water pump at 120° C. until no ethanol dropped out.
The residue was distilled under vacuum to give the title compound as a colorless transparent liquid (111 g, 81.2percent yield, purity 97percent by GC)
44.5 g With sodium ethanolate In ethanol at 80℃; The 1000 ml hydrogenation vessel was evacuated and then passed through nitrogen,Then add 500ml ethanol, 2g5percent Pd / C, 2.5g caustic soda, cool to -10 ,Slowly add 50g of S-glycidol,Then, hydrogen gas (about 2 atmospheres) was passed for 4 hours,To no longer consume hydrogen so far, filtered and concentrated to give 48 g of a colorless oil.
References: [1] Patent: CN105859781, 2016, A, . Location in patent: Paragraph 0011-0012.
[2] Patent: US2010/216822, 2010, A1, . Location in patent: Page/Page column 13.
[3] Tetrahedron Letters, 1998, vol. 39, # 14, p. 1853 - 1856.
[4] Patent: EP1243590, 2002, A2, . Location in patent: Page 9.
[5] Patent: CN102977146, 2016, B, . Location in patent: Paragraph 0016; 0021; 0023.
[6] Patent: CN108358968, 2018, A, . Location in patent: Paragraph 0073; 0087-0089; 0134-0136; 0142-0144; 0150-0152.
[7] Patent: JP2015/164934, 2015, A, . Location in patent: Paragraph 0166; 0167; 0173.
  • 2
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  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
99% at 120℃; for 4 h; Autoclave General procedure: For a typical reaction of CO2with epoxides, ZnBr2(11.3 mg,0.05 mmol), [BMIM]Br (65 mg, 0.3 mmol) and epoxides (PO: 20 ml,0.286 mol; or ECH: 23.61 g, 0.255 mmol) were charged into a100 ml stainless steel autoclave equipped with a magnetic stirrerin sequence. The 3.0 MPa of CO2was filled into the reaction ves-sel which was then heated to 120C for 4 h. Once the reaction iscompleted, the vessel was cooled to room temperature and thegas was released slowly. Then the liquid phase was analyzed byHP7890A/5975C GC–MS. The unreacted substrate was then dis-tilled out from the mixture, and the product was obtained. Theenantiomeric purity of the mixture was analyzed by HP7890A GCequipped with a chiral DEX120 chromatography column.
References: [1] Journal of Organic Chemistry, 2008, vol. 73, # 20, p. 8039 - 8044.
[2] Journal of Molecular Catalysis A: Chemical, 2014, vol. 385, p. 133 - 140.
[3] ChemSusChem, 2017, vol. 10, # 15, p. 3025 - 3029.
[4] Green Chemistry, 2017, vol. 19, # 16, p. 3769 - 3779.
[5] Journal of the American Chemical Society, 2014, vol. 136, # 43, p. 15270 - 15279.
[6] Chemical Communications, 2004, # 14, p. 1622 - 1623.
[7] Journal of the American Chemical Society, 2001, vol. 123, # 46, p. 11498 - 11499.
[8] Advanced Synthesis and Catalysis, 2009, vol. 351, # 9, p. 1325 - 1332.
[9] Green Chemistry, 2011, vol. 13, # 3, p. 644 - 650.
[10] Inorganic Chemistry, 2012, vol. 51, # 21, p. 12041 - 12052,12.
[11] Journal of Organic Chemistry, 2014, vol. 79, # 20, p. 9771 - 9777.
[12] ACS Catalysis, 2015, vol. 5, # 11, p. 6773 - 6779.
  • 3
  • [ 124-38-9 ]
  • [ 75-56-9 ]
  • [ 51260-39-0 ]
  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
34.2% With C126H91CoN12O10; tetrabutyl-ammonium chloride In dichloromethane at 25℃; for 96 h; Autoclave General procedure: All reactions were conducted in a 100 mL stainless steel autoclave equipped with a magnetic stir bar, and submerged in anoil bath. The required catalyst, tetrabutylammonium chloride (TBAC) as the co‐catalyst, epoxide, and CH2Cl2 were added tothe reactor in turn. The reactor was then charged with CO2 and vented three times, and finally pressurized with CO2 to 1.0 MPa. The contents were then stirred at room temperature for an established period that depended on the selected substrate and catalyst, after which the reactor was carefully discharged to atmospheric pressure. The yield of cyclic carbonate was determinedby the subtraction method or by comparison betweenthe integral areas obtained by 1H NMR spectroscopy for thecyclic carbonate and epoxide.
31.6% With C126H91CoN12O10; tetrabutyl-ammonium chloride In dichloromethane at 25℃; for 96 h; Autoclave General procedure: All reactions were conducted in a 100 mL stainless steel autoclave equipped with a magnetic stir bar, and submerged in anoil bath. The required catalyst, tetrabutylammonium chloride (TBAC) as the co‐catalyst, epoxide, and CH2Cl2 were added tothe reactor in turn. The reactor was then charged with CO2 and vented three times, and finally pressurized with CO2 to 1.0 MPa. The contents were then stirred at room temperature for an established period that depended on the selected substrate and catalyst, after which the reactor was carefully discharged to atmospheric pressure. The yield of cyclic carbonate was determinedby the subtraction method or by comparison betweenthe integral areas obtained by 1H NMR spectroscopy for thecyclic carbonate and epoxide.
38.8 % ee at 25℃; for 25 h; Autoclave General procedure: A solution of freshly prepared SalenCo(III)Y (0.1 mmol) andepoxide (100 mmol) was introduced into a 100 mL stainless-steelautoclave, which was purged three times and charged with CO2to 1.2 MPa. The reaction mixture was stirred at room temperature.When the pressure of reactor was fall down to a presetting value, itwas then vented carefully. After removing the excess epoxide, theresidue was weighed to measure the conversion of epoxide, chiralcyclic carbonate (R = Me, Et, CH2Cl) was distilled under vacuum as asa colorless liquid or it (R = Ph, PhOCH2) was obtained by columnchromatography through a short silica–gel column to yield whitesolid product (ethyl acetate/petroleum ether = 5:1).
References: [1] Dalton Transactions, 2013, vol. 42, # 27, p. 9930 - 9937.
[2] Chinese Journal of Catalysis, 2018, vol. 39, # 5, p. 997 - 1003.
[3] Chinese Journal of Catalysis, 2018, vol. 39, # 5, p. 997 - 1003.
[4] Journal of the American Chemical Society, 2004, vol. 126, # 12, p. 3732 - 3733.
[5] Chemical Communications, 2004, # 14, p. 1622 - 1623.
[6] Tetrahedron Letters, 2007, vol. 48, # 2, p. 297 - 300.
[7] Tetrahedron Letters, 2008, vol. 49, # 46, p. 6589 - 6592.
[8] Advanced Synthesis and Catalysis, 2009, vol. 351, # 9, p. 1325 - 1332.
[9] Advanced Synthesis and Catalysis, 2009, vol. 351, # 9, p. 1325 - 1332.
[10] Green Chemistry, 2009, vol. 11, # 7, p. 935 - 938.
[11] Green Chemistry, 2009, vol. 11, # 7, p. 935 - 938.
[12] Science China Chemistry, 2011, vol. 54, # 7, p. 1044 - 1050.
[13] Science China Chemistry, 2011, vol. 54, # 7, p. 1044 - 1050.
[14] Catalysis Science and Technology, 2013, vol. 3, # 10, p. 2661 - 2667.
[15] Journal of Molecular Catalysis A: Chemical, 2016, vol. 411, p. 34 - 39.
[16] RSC Advances, 2016, vol. 6, # 4, p. 3243 - 3249.
[17] Chemical Communications, 2017, vol. 53, # 79, p. 10930 - 10933.
[18] Chemical Communications, 2017, vol. 53, # 79, p. 10930 - 10933.
[19] Chinese Journal of Catalysis, 2018, vol. 39, # 5, p. 997 - 1003.
  • 4
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  • [ 15448-47-2 ]
  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
66.7 % ee at 25℃; for 8 h; Autoclave General procedure: Catalyst of (S,R,R,S)-ZSS-2b (631 mg, 0.1 mmol), cocatalyst of tetrabutylammonium fluoride (TBAF, 0.0522 g, 0.2 mmol), and racemic propylene oxide (PO, 7 mL, 100 mmol) were introduced into a 100-mL stainless steel autoclave to form a brown solution. The reactor was purged thrice with carbon dioxide, and charged it to 0.8 MPa. Then, the asymmetric catalytic reaction took place at room temperature. After some time, the pressure in the reactor decreased to an expected value, and it was vented to terminate the reaction. After removing the unreacted epoxide, chiral cyclic carbonate (R=Me, Et, CH2Cl), weighed to calculate the yield of cyclic carbonate, was distilled under vacuum as a colorless liquid or it (R=Ph, PhOCH2) was obtained by column chromatography through a short silica gel column (ethyl acetate:petroleum ether = 5:1).
References: [1] Tetrahedron Asymmetry, 2008, vol. 19, # 16, p. 1947 - 1953.
[2] Catalysis Communications, 2016, vol. 81, p. 50 - 53.
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YieldReaction ConditionsOperation in experiment
66.8 % ee at 0℃; for 8 h; Autoclave General procedure: Catalyst of (S,R,R,S)-ZSS-2b (631 mg, 0.1 mmol), cocatalyst of tetrabutylammonium fluoride (TBAF, 0.0522 g, 0.2 mmol), and racemic propylene oxide (PO, 7 mL, 100 mmol) were introduced into a 100-mL stainless steel autoclave to form a brown solution. The reactor was purged thrice with carbon dioxide, and charged it to 0.8 MPa. Then, the asymmetric catalytic reaction took place at room temperature. After some time, the pressure in the reactor decreased to an expected value, and it was vented to terminate the reaction. After removing the unreacted epoxide, chiral cyclic carbonate (R=Me, Et, CH2Cl), weighed to calculate the yield of cyclic carbonate, was distilled under vacuum as a colorless liquid or it (R=Ph, PhOCH2) was obtained by column chromatography through a short silica gel column (ethyl acetate:petroleum ether = 5:1).
References: [1] Catalysis Communications, 2016, vol. 81, p. 50 - 53.
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References: [1] Synthesis, 2009, # 8, p. 1403 - 1404.
  • 7
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  • [ 1015235-28-5 ]
  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
99.67 % ee With sodium hydroxide In water at 20℃; for 25.5 h; Aqueous phosphate buffer; D-glucose Example 1 Biocatalytic reduction of 0- (methoxycarbonyl) -hydroxyacetone, 2a :4aIn a Titrino reaction vessel, the whole-cell catalyst of type E. coli DSM14459, containing an (R) -alcohol dehydrogenase from L. kefir and a glucose dehydrogenase from T. acidophilum (for production of the biocatalyst, see WO2005121350) , at a cell concentration of 55 g moist biomass / L, D-glucose (1.5 equivalents relative to the molar amount of ketone used) and 25 mmol 0-(methyloxycarbonyl) -hydroxyacetone, 2a, (corresponding to a substrate concentration of 0.5M) are added to 30 mL of an aqueous phosphate buffer (0.026 M; adjusted to pH 7.0) and the volume is topped up to 50 mL with water. The reaction mixture is stirred for a reaction time of 25.5 hours at room temperature, maintaining constant pH at -6.5 by adding sodium hydroxide solution (5M NaOH). After a reaction time of 25.5 hours, conversion of >95percent is determined (according to the consumption of sodium hydroxide solution and GC chromatography) . Processing is carried out by lowering the pH value to <3 with concentrated hydrochloric acid and addition of 3.75 g of the filter aid Celite Hyflo <n="25"/>Supercel to the reaction mixture, followed by filtration with application of vacuum. The filter cake is washed 4 times with 50 mL MTBE and the aqueous phase is extracted correspondingly with the three organic MTBE fractions obtained. The solvent is removed from the combined organic phases after drying over magnesium sulphate, yielding as raw product the optically active alcohol 3a at a yield of 50percent (of which 12.7 mol.percent is rearranged to give the regioisomeric alcohol 4a and 63.6 mol.percent has already been cyclized to the desired (R) -propylene carbonate 1) . The enantioselectivity of the reaction is 99.67percent ee .
References: [1] Patent: WO2008/34685, 2008, A1, . Location in patent: Page/Page column 22-23.
  • 8
  • [ 105235-63-0 ]
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  • [ 1015235-31-0 ]
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YieldReaction ConditionsOperation in experiment
99.34 % ee With sodium hydroxide In water at 20℃; for 25.5 h; Aqueous phosphate buffer; D-glucose Example 2_Biocatalytic reduction of 0- (ethoxycarbonyl) - hydroxyacetone, 2b:4bIn a Titrino reaction vessel, the whole-cell catalyst of type E. coli DSM14459, containing an (R) -alcohol dehydrogenase from L. kefir and a glucose dehydrogenase from T. acidophilum (for production of the biocatalyst, see WO2005121350) , at a cell concentration of 51 g moist biomass / L, D-glucose (1.5 equivalents relative to the molar amount of ketone used) and 25 mmol 0- (ethyloxycarbonyl) -hydroxyacetone, 2b, (corresponding to a substrate concentration of 0.5M) are added to 30 mL of an aqueous phosphate buffer (0.026 M; adjusted to pH 7.0) and the volume is topped up to 50 mL with water. The reaction mixture is stirred for a reaction time of 25.5 hours at room temperature, maintaining constant pH at -6.5 by adding sodium hydroxide solution (5M NaOH) . After a reaction time of 25.5 hours, conversion of >95percent is determined (according to the consumption of sodium hydroxide solution and GC chromatography) . Processing is carried out by lowering the pH value to <3 with concentrated hydrochloric acid and addition of 3.75 g of the filter aid Celite Hyflo Supercel to the reaction mixture, followed by filtration with application of vacuum. The filter cake is washed 4 times with 50 mL MTBE and the aqueous phase <n="27"/>is extracted correspondingly with the three organicMTBE fractions obtained. The solvent is removed from the combined organic phases after drying over magnesium sulphate, yielding as raw product the optically active alcohol 3b at a yield of 71percent (of which 37.3 mol.percent is rearranged to give the regioisomeric alcohol 4a and18.6 mol.percent has already been cyclized to the desired(R) -propylene carbonate 1) . The enantioselectivity of the reaction is 99.34percent ee
References: [1] Patent: WO2008/34685, 2008, A1, . Location in patent: Page/Page column 24-25.
  • 9
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  • [ 16606-55-6 ]
YieldReaction ConditionsOperation in experiment
99.18 % ee at 60℃; for 6 h; Example 4_Synthesis of (R) -propylene carbonate 1 by cyclization of the raw product from Example 2:HO.XH-,4b0.525 g of the optically active alcohol 3b obtained as raw product according to example 2 (which has partially been rearranged to give the regioisomeric alcohol 4b or has already been cyclized to the desired (R) -propylene carbonate according to the proportions stated in mol.percent in example 2) is absorbed in 10 mL ethyl acetate, and p-toluenesulphonic acid (96 mg) is added. The reaction mixture is heated for 6 hours at a reaction temperature of 600C. The desired (R) -propylene carbonate 1 is obtained in a proportion of -80percent (relative to the molar quantity of substrate used from example 2) and with an enantioselectivity of 99.18percent ee
References: [1] Patent: WO2008/34685, 2008, A1, . Location in patent: Page/Page column 28.
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  • [ 584-08-7 ]
  • [ 16606-55-6 ]
References: [1] Patent: US6054596, 2000, A, .
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  • [ 15448-47-2 ]
  • [ 16088-62-3 ]
  • [ 16606-55-6 ]
References: [1] Organic Letters, 2006, vol. 8, # 20, p. 4401 - 4404.
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References: [1] Organic Letters, 2006, vol. 8, # 20, p. 4401 - 4404.
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References: [1] European Journal of Organic Chemistry, 2018, vol. 2018, # 23, p. 2931 - 2938.
 

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