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Chemical Structure| 584-08-7 Chemical Structure| 584-08-7
Chemical Structure| 584-08-7

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Synonyms: Potassium carbonate

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Beteck, Richard M ; Legoabe, Lesetja J ; Dube, Phelelisiwe S ; Jordaan, Audrey ; Warner, Digby F ;

Abstract: Diphenyl ether and quinoline based compounds have been reported to show antibacterial activity. Against Mycobacterium tuberculosis, drug targets inhibited by diphenyl ether compounds are reportedly different from those perturbed by quinoline based antitubercular hits/drugs. Herein, we conceptualized and synthesized novel molecules incorporating quinoline and diphenyl ether moieties. The antitubercular property of the synthesized compounds were measured in vitro using Tween 80 and Tyloxapol supplemented growth media. Compounds in this study generally showed sub micromolar antitubercular activity in tween 80/ albumin supplemented growth medium, and moderate to poor activity in tyloxapol/casitone supplemented growth medium. Compound 4e, havin a trimethylenediamine moiety and low melting point of 68°C, emerged as the hit compound, possessing MIC90 value of 0.2 µM. 4e is non-cytotoxic when tested against normal human cell line, exhibiting CC50 value > 20 µM.

Keywords: Quinoline ; Diphenyl ether ; Tuberculosis ; Cytotoxicity ; Antitubercular

Purchased from AmBeed: ;

Gendron, David ; Labrecque, Josée ;

Abstract: This report discusses the synthesis of a biosourced divanillin derivative obtained by Knoevenagel condensation. The compound was fully characterized by proton (1H), carbon (13C), heteronuclear single quantum coherence (HSQC), homonuclear correlation spectroscopy (COSY), and heteronuclear multiple bond correlation (HMBC) NMR, as well as high-resolution mass spectroscopy (HRMS). We also investigated the optical properties through UV-visible spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. At last, the thermal properties of this divanillin derivative were evaluated by thermogravimetric analysis (TGA) as well as differential scanning calorimetry (DSC).

Keywords: vanillin ; biosourced ; Knoevenagel condensation ; dyes ; organic pigments

Purchased from AmBeed: ;

Tang, Jian-Hong ; Luo, Minrui ; Tsao, Wilhelmina ; Waters, Emily Alexandria ; Parigi, Giacomo ; Luchinat, Claudio , et al.

Abstract: Glycoconjugates forming from the conjugation of carbohydrates to other biomolecules, such as proteins, lipids, or other carbohydrates, are essential components of mammalian cells and are involved in numerous biological processes. Due to the capability of sugars to form multiple hydrogen bonds, many synthetic glycoconjugates are desirable biocompatible platforms for imaging, diagnostics, drugs, and supramolecular self-assemblies. Herein, we present a multimeric galactose functionalized paramagnetic gadolinium (Gd(III)) chelate that displays spontaneous dynamic aggregation in aqueous conditions. The dynamic aggregation of the Gd(III) complex was shown by the concentration-dependent magnetic resonance (MR) relaxation measurements, nuclear magnetic resonance dispersion (NMRD) analysis, and dynamic light scattering (DLS). Notably, these data showed a nonlinear relationship between magnetic resonance relaxation rate and concentrations (0.03−1.35 mM), and a large DLS hydrodynamic radius was observed in the high-concentration solutions. MR phantom images were acquired to visualize real-time dynamic aggregation behaviors in aqueous solutions. The in situ visualization of the dynamic self-assembling process of multivalent glycoconjugates has rarely been reported.

Purchased from AmBeed: ; ;

Qing Yun Li ; Leigh Anna Hunt ; Kalpani Hirunika Wijesinghe ; Christine Curiac ; Ashley Williams ; Amala Dass , et al.

Abstract: Strong photoinduced oxidants are important to organic synthesis and solar energy conversion, to chemical fuels or electric. For these applications, visible light absorption is important to solar energy conversion and long-lived excited states are needed to drive catalysis. With respect to these desirable qualities, a series of five 5,6-dicyano[2,1,3]benzothiadiazole (DCBT) dyes are examined as organic chromophores that can serve as strong photooxidants in catalytic systems. The series utilizes a DCBT core with aryl groups on the periphery with varying electron donation strengths relative to the core. The dyes are studied via both steady-state and transient absorption and emission studies. Additionally, computational analysis, voltammetry, crystallography, and absorption spectroelectrochemistry are also used to better understand the behavior of these dyes. Ultimately, a strong photooxidant is arrived at with an exceptionally long excited state lifetime for an organic chromophore of 16 µs. The long-lived excited state photosensitizer is well-suited for use in catalysis, and visible light driven photosensitized water oxidation is demonstrated using a water-soluble photosensitizer.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; 51364-51-3 ; 538-75-0 ; 584-08-7 ; 1122-91-4 ; 123-30-8 ; 108-88-3 ; 109-77-3 ; 64-19-7 ; 603-35-0

Hintzsche, Samuel J. ; Vang, Zoua Pa ; Rivera Torres, Emanuel ; Podoski, Mykaela ; Clark, Joseph R. ;

Abstract: Selective deuterium installation into small molecules is becoming increasingly desirable not only for the elucidation of mechanistic pathways and studying biological processes but also because of deuterium's ability to favorably adjust the pharmacokinetic parameters of bioactive molecules. Fused bicyclic moieties, especially those containing heteroatoms, are prevalent in drug discovery and pharmaceuticals. Herein, we report a copper-catalyzed transfer hydrodeuteration of cyclic and heterocyclic alkenes, which enables the synthesis of chromans, quinolinones, and tetrahydronaphthalenes that are precisely deuterated at the benzylic position. We also demonstrate the ability to place one deuterium atom at the homobenzylic site of these scaffolds with high regioselectivity by swapping transfer reagents for their isotopic analogs. Furthermore, examples of chemoselective transfer hydrogenation and transfer deuteration are disclosed, allowing for the simultaneous incorporation of two vicinal hydrogen or deuterium atoms into a double bond.

Keywords: copper ; deuteration ; hydrodeuteration ; hydrogenation ; transition metal catalysis

Purchased from AmBeed: ; ; ; ; ; ;

Alternative Products

Product Details of Potassium carbonate

CAS No. :584-08-7
Formula : K2CO3
M.W : 138.21
SMILES Code : [O-]C([O-])=O.[K+].[K+]
Synonyms :
Potassium carbonate
MDL No. :MFCD00011382
InChI Key :BWHMMNNQKKPAPP-UHFFFAOYSA-L
Pubchem ID :11430

Safety of Potassium carbonate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P264-P270-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P501

Application In Synthesis of Potassium carbonate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 584-08-7 ]
  • Downstream synthetic route of [ 584-08-7 ]

[ 584-08-7 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 1722-12-9 ]
  • [ 57260-73-8 ]
  • [ 584-08-7 ]
  • [ 137583-05-2 ]
References: [1] Patent: US6159964, 2000, A, .
  • 2
  • [ 181955-94-2 ]
  • [ 584-08-7 ]
  • [ 7757-82-6 ]
  • [ 85817-34-1 ]
YieldReaction ConditionsOperation in experiment
78% With sodium cyanoborohydride; benzaldehyde; acetic acid In tetrahydrofuran; methanol 3.
4-Benzyl-2-hydroxymethylpiperazine
To a cooled (0° C.) and stirred solution of Intermediate 1 (22 g, 57 mmol), acetic acid (9.7 mL, 171 mmol) and sodium cyanoborohydride (7.16 g, 114 mmol) in methanol (440 mL) was added benzaldehyde (5.8 mL, 57 mmol).
The cooling bath was removed and the mixture stirred at room temperature for 3 h.
Saturated K2 CO3 solution (200 mL) was added and the mixture stirred for 15 min.
The solvents were evaporated and the residue partitioned between CH2 Cl2 (2*400 mL) and water (500 mL).
The combined organic layers were dried (Na2 SO4) and evaporated.
The residue was chromatographed on silica gel, eluding with CH2 Cl2: MeOH (95:5) to afford an inseparable mixture of 4-benzylpiperazine-2-carboxylic acid methyl ester and the corresponding ethyl ester (5.33 g, 40percent), in a 7:1 ratio respectively.
To a solution of the esters (5.33 g, 22.8 mmol) in THF (200 mL) was added LiAl H4 (22.8 mL of a 1.0M solution in ether) dropwise at -10° C.
Stirring was continued at -10° C. for 2.5 h.
After this time saturated Na2 SO4 solution (30 mL) was added and the cooling bath removed.
Stirring was continued at room temperature for 10 min then the mixture was filtered and the filtrate evaporated.
The residue was chromatographed on silica gel, eluding with CH2 Cl2:MeOH:NH3 (90:8:1-->60:8:1) to afford the title compound (3.7 g, 78percent) as a colourless oil. 1 H NMR (360 MHz, CDCl3) δ 1.89-1.95 (1H, m), 2.08-2.30 (3H, m), 2.68-2.71 (2H, m), 2.86-3.04 (3H, m), 3.45-3.60 (4H, m), 7.13-7.32 (5H, m). MS (ES+) 207 (M+1).
References: [1] Patent: US5849746, 1998, A, .
  • 3
  • [ 57-55-6 ]
  • [ 584-08-7 ]
  • [ 16606-55-6 ]
References: [1] Patent: US6054596, 2000, A, .
  • 4
  • [ 2457-50-3 ]
  • [ 7677-24-9 ]
  • [ 584-08-7 ]
  • [ 79-44-7 ]
  • [ 159307-02-5 ]
References: [1] Patent: US5350696, 1994, A, .
[2] Patent: US5559214, 1996, A, .
[3] Patent: US5760191, 1998, A, .
 

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