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Chemical Structure| 1822-32-8 Chemical Structure| 1822-32-8

Structure of 1822-32-8

Chemical Structure| 1822-32-8

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Product Details of [ 1822-32-8 ]

CAS No. :1822-32-8
Formula : C8H15NO2
M.W : 157.21
SMILES Code : OC(=O)CCC1CCNCC1
MDL No. :MFCD03412486

Safety of [ 1822-32-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H318
Precautionary Statements:P280-P305+P351+P338
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 1822-32-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1822-32-8 ]

[ 1822-32-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1822-32-8 ]
  • [ 24424-99-5 ]
  • [ 154775-43-6 ]
YieldReaction ConditionsOperation in experiment
79% Step B. 1-tert-Butoxycarbonyl-4-piperidinepropionic acid 4-Piperidinepropionic acid (13.4mmoles) (prepared as described in Step A above), di-tert-butyldicarbonate (3.22g, 14.75mmoles) and sodium hydroxide (0.5364g, 13.4mmoles) are dissolved in THF-water (1:1) (40ml) and the mixture is stirred at 25C for 18h. The mixture is passed over Bio Rad 50WX4 (H+) resin (15ml bed) and the resin is washed with THF-water. The combined eluates are evaporated to dryness and then azeotroped with THF to give the title compound (2.72g, 79%), FABMS: m/z 258.1 (MH+).
  • 2
  • [ 1822-32-8 ]
  • [ 39903-01-0 ]
  • [ 364385-46-6 ]
  • 3
  • [ 154775-43-6 ]
  • [ 1822-32-8 ]
  • 4
  • [ 1822-32-8 ]
  • [ 154775-43-6 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In sodium hydroxide; N,N-dimethyl-formamide; (b) 3-[1-(t-Butyloxycarbonyl)piperidin4-yl]propanoic acid A suspension of 3-(piperidin4-yl)propanoic acid in 500 ml of N,N-dimethylformamide was treated with 30.9 g of di t-butyl dicarbonate. The pH of the reaction was adjusted at pH 8.5 using triethylamine and stirred for 4 hours at room temperature. The mixture was poured in 65 ml of a cooled 2 N sodium hydroxide solution and washed with ethyl acetate. The aqueous phase was acidified with 2 N hydrochloric acid pH 2 and extracted with ethyl acetate. The combined organic layers were washed with brine, dried on sodium sulphate and evaporated in vacuo to yield 37 g of the desired compound. TLC: Rf=0.7, dichloromethanetmethanol 9/1 v/v on silica gel
 

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