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Chemical Structure| 18595-87-4 Chemical Structure| 18595-87-4

Structure of 18595-87-4

Chemical Structure| 18595-87-4

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Product Details of [ 18595-87-4 ]

CAS No. :18595-87-4
Formula : C15H11NO2
M.W : 237.25
SMILES Code : O=C1OC(C2=CC=CC=C2C)=NC3=CC=CC=C13
MDL No. :MFCD00087552

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Application In Synthesis of [ 18595-87-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18595-87-4 ]

[ 18595-87-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 18595-87-4 ]
  • [ 162167-97-7 ]
  • C26H31N3O3 [ No CAS ]
  • 2
  • [ 615-37-2 ]
  • [ 201230-82-2 ]
  • [ 615-43-0 ]
  • [ 18595-87-4 ]
YieldReaction ConditionsOperation in experiment
75% With N-ethyl-N,N-diisopropylamine; In toluene; at 110℃; under 3750.38 Torr; for 24h;Inert atmosphere; General procedure: MCM-41-Pd(OAc)2 (5 mol%), 2-iodoaniline 1 (1.2 mmol) and aryl iodide2 (1.0 mmol) (if solid). The vial was purged with argon and then aryl iodide 2 (1.0 mmol) (if liquid), DiPEA (4.0 mmol), and toluene (2mL) were injected by syringe. The vial was placed in an alloy plate and the plate was then transferred into a 300 mL autoclave under argon. After the autoclave had been flushed with CO (3×), the CO pressure was adjusted to 5 bar and the reaction was carried out for 24 h at 110C. Upon completion of the reaction, the autoclave was cooled to ambient temperature and the pressure was released cautiously. EtOAc(10 mL) was then added and the resulting mixture was filtered. The Pd catalyst was recovered, by washing with distilled water (2 × 5 mL) and acetone (2 × 5 mL), followed by drying under vacuum at 80 C for 2 h, and reused in the next cycle. The filtrate was washed with water (2 × 10 mL) and dried over anhydrous MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, light PE-EtOAc, 10:1) to afford the desired product 3.
 

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