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Chemical Structure| 19293-62-0 Chemical Structure| 19293-62-0

Structure of 19293-62-0

Chemical Structure| 19293-62-0

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Product Details of [ 19293-62-0 ]

CAS No. :19293-62-0
Formula : C15H17NO2
M.W : 243.30
SMILES Code : NC(C1=CC=C(OC)C=C1)C2=CC=C(OC)C=C2
MDL No. :MFCD00191409
InChI Key :HROGQYMZWGPHIB-UHFFFAOYSA-N
Pubchem ID :350042

Safety of [ 19293-62-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 19293-62-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19293-62-0 ]

[ 19293-62-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2689-69-2 ]
  • [ 19293-62-0 ]
  • [ 149622-18-4 ]
YieldReaction ConditionsOperation in experiment
With toluene-4-sulfonic acid; In water; toluene; benzene; Example VI Methyl 3-N-(4,4'-dimethoxybenzhydryl)amino-4,5-dihydro-thiophene-2-carboxylate STR26 A solution of 4.5 g (28.0 nunol) of methyl tetrahydrothiophene-3-one-2-carboxylate, 6.9 g (28 mmol) of 4,4'-dimethoxy-benzhydrylamine and 0.1 g of p-toluenesulphonic acid are heated under reflux in a water separator in 50 ml of benzene for 24 h. The mixture is then diluted with 40 ml of toluene, and washed with 40 ml of 1% strength aqueous NaHCO3 solution and twice with 30 ml of water in each case. The organic phase is dried over Na2 SO4 and the solvent is stripped off in vacuo. The residue is chromatographed on silica gel (ether/petroleum ether =1:2) Yield: 7.58 g (70% of theory). C21 H23 NO4 S(385.4). Rf =0.42 (ether: petroleum ether =1:2).
  • 2
  • [ 1187992-93-3 ]
  • [ 19293-62-0 ]
  • [ 1187990-87-9 ]
YieldReaction ConditionsOperation in experiment
To a suspension of Intermediate 8 (14.94 g, 68.5 mmol) in DMF (225 mL) was added TEA (18.98 mL, 137 mmol) and CDI (11.10 g, 68.5 mmol). The reaction was heated at 120 C. for 1 h followed by the addition of 4,4'-dimethoxybenzhydrlamine (14.99 g, 61.6 mmol). The reaction was heated at 115 C. for 1 h, diluted with CHCl3, washed with aq. HCl (1 M), deionized H2O and concentrated. The material was crystallized from the residue using EtOH to afford the title compound. HPLC/MS: 444.18 (M+1); Rt=2.90 min.
 

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