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Chemical Structure| 932-30-9 Chemical Structure| 932-30-9
Chemical Structure| 932-30-9

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2-(Aminomethyl)phenol is a selective dicarbonyl scavenger with antioxidant and free radical scavenging capabilities, used in studies of inflammation and cardiovascular diseases.

Synonyms: 2-Hydroxybenzylamine; o-Hydroxybenzylamine; NSC 127870

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Product Details of 2-(Aminomethyl)phenol

CAS No. :932-30-9
Formula : C7H9NO
M.W : 123.15
SMILES Code : OC1=CC=CC=C1CN
Synonyms :
2-Hydroxybenzylamine; o-Hydroxybenzylamine; NSC 127870
MDL No. :MFCD00870498
InChI Key :KPRZOPQOBJRYSW-UHFFFAOYSA-N
Pubchem ID :70267

Safety of 2-(Aminomethyl)phenol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2-(Aminomethyl)phenol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932-30-9 ]

[ 932-30-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 932-30-9 ]
  • [ 112811-71-9 ]
  • C23H23FN2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In acetonitrile; at 120℃; for 6h; Three-necked flask was charged with 100 g of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate,Adding 600mL of acetonitrile, stirring, adding 2-hydroxybenzylamine 37mL, heating to 120 C for 6h, cooling, pouring the reaction solution into 1mol / L dilute hydrochloric acid, stirring, adding 500mLEA extraction,The aqueous phase was extracted with EA 300 mL × 2 and the organic layers were combined, dried and evaporated to dryness to give 92.3 g of the yellow product which was used in the next step without further purification.
  • 2
  • [ 1206675-01-5 ]
  • [ 932-30-9 ]
  • 3
  • [ 932-30-9 ]
  • [ 64-19-7 ]
  • [ 1206675-01-5 ]
YieldReaction ConditionsOperation in experiment
35.4 g 9. The dried solid was dissolved in 420 g of glacial acetic acid and stirred for 16-24 hours.10. To the reaction system, 932 g of methyl tert-butyl ether was added, and the mixture was stirred and crystallized at 0 to 10 C for 4 to 6 hours.11. Centrifuge the system, centrifuge the solids with 250 ml of 85% ethanol and centrifuge again.12. Centrifuge the solid at 40-50 C to dry, to obtain the final product 35.4g, white.
 

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