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Chemical Structure| 20098-19-5 Chemical Structure| 20098-19-5

Structure of 20098-19-5

Chemical Structure| 20098-19-5

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Product Details of [ 20098-19-5 ]

CAS No. :20098-19-5
Formula : C10H18ClNO
M.W : 203.71
SMILES Code : OC12CC3C(N)C(C2)CC(C3)C1.[H]Cl
MDL No. :MFCD01825646
InChI Key :KWEPNQFVPHYHHO-UHFFFAOYSA-N
Pubchem ID :2857446

Safety of [ 20098-19-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 20098-19-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20098-19-5 ]

[ 20098-19-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20098-19-5 ]
  • [ 2972-52-3 ]
  • 2,4-dichloro-N-[(2s,5r)-5-hydroxyadamantan-2-yl]pyrimidine-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 0℃; for 4h; A suspension of 4-aminoadamantan-1-ol hydrochloride (2.89 g, 14.2 mmol) in THF (20 mL) was added dropwise to a stirred solution of <strong>[2972-52-3]2,4-dichloropyrimidine-5-carbonyl chloride</strong> (CAS No. 2972-52-3, 3.00 g, 14.2 mmol) and DIPEA (4.91 mL, 28.4 mmol) in DCM (20 mL) at -10 C. The resulting suspension was stirred at 0 C. for 4 h. The reaction mixture was diluted with DCM and washed sequentially with 0.1 M aq. HCl, water and sat. brine. The organic layer was dried over MgSO4, filtered and evaporated. The crude solid was triturated with ice-cold DCM to afford the title compound (3.20 g, 66%) as a tan solid; 1H NMR (400 MHz) 1.36 (2H, d), 1.63 (4H, d), 1.71-1.77 (3H, m), 1.86 (2H, d), 1.98-2.00 (1H, m), 2.06 (2H, s), 3.95 (1H, t), 8.51 (1H, d), 8.83-8.85 (1H, m); m/z MH+=342; HPLC tR=1.44 min.
 

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