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Chemical Structure| 2051-76-5 Chemical Structure| 2051-76-5

Structure of 2051-76-5

Chemical Structure| 2051-76-5

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Product Details of [ 2051-76-5 ]

CAS No. :2051-76-5
Formula : C6H6O3
M.W : 126.11
SMILES Code : C=CC(OC(C=C)=O)=O
MDL No. :MFCD00048146
InChI Key :ARJOQCYCJMAIFR-UHFFFAOYSA-N
Pubchem ID :74919

Safety of [ 2051-76-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 2051-76-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2051-76-5 ]

[ 2051-76-5 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 2051-76-5 ]
  • [ 4089-07-0 ]
  • (S)-N-Acryloyl-tyrosin-ethylester [ No CAS ]
  • 3
  • [ 7446-81-3 ]
  • [ 98-88-4 ]
  • [ 2051-76-5 ]
YieldReaction ConditionsOperation in experiment
Example 3 Synthesis of Acrylic Anhydride from Benzoyl Chloride A 60.09 g (0.4277 mol) sample of benzoyl chloride was added to a 500-ml round-bottomed flask equipped with a magnetic stirring bar. 30.02 g (0.3194 mol) of <strong>[7446-81-3]sodium acrylate</strong> were then added and stirred for 30 minutes, after which another 15.21 g (0.1618 mol) portion of <strong>[7446-81-3]sodium acrylate</strong> was added in one portion, and stirring was continued for additional 30 minutes under the same conditions. The mixture was vacuum filtered neat to obtain 56.41 g of crude product. It should be noted that a more efficient vacuum filtration system would increase the percent recovery of the crude products. Acrylic anhydride was distilled at 65°-67° C. and about 5-10 mm Hg pressure to afford 20.84 g (77.3percent yield). MS data: m/z 98 (<2,M-CO), 55 (100, CH2 =CH-CO+). IR data: 1794.5 and 1730.2 cm-1 C=O,16.28.9 cm-1 C=C. P-NMR data: vinyl protons all giving doublets of doublets at 6,587, 6,591 and 6.531, 6.535 ppm; 6.227, 6.193 and 6.171, 6.137 ppm; and 6.092, 6,087 and 6.057, 6.053 ppm respectively. C-13 NMR data: 162 ppm (C=O), 135 ppm and 128 ppm (C=C). The residual material in the distillation flask was found to be 31.68 g benzoic anhydride (65.6percent yield).
  • 4
  • [ 2051-76-5 ]
  • [ 100-46-9 ]
  • [ 13304-62-6 ]
YieldReaction ConditionsOperation in experiment
5.65 g With sodium hydrogencarbonate; sodium hydroxide; In water; toluene; at 0 - 25℃; for 0.5h;Inert atmosphere; General procedure: Benzylamine (11.7 g, 0.11 moles) serving as the material, toluene (25.9 g, 30 mL) serving as the solvent and 9% sodium hydroxide aqueous solution (87.9 g, 0.20 moles) serving as the base were charged in a 500-mL reaction container equipped with a nitrogen gas supplying pipe, a thermometer, and a stirrer in a nitrogen atmosphere, and the reacting solution was cooled such that the inner temperature came to be 0 C., being stirred at 300 rpm. After the cooling, the reacting solution was regarded as a base solution and the toluene solution of diacrylic anhydride obtained in Step 1 was dropped into the base solution, being stirred, such that the inner temperature did not exceed 5 C., i.e., being controlled in the temperature range of 0 C. to 5 C. After the completion of the dropping, the jacket temperature was raised to 25 C. and the reaction solution was stirred for 30 minutes. After the completion of the stirring, the reaction solution was stood still for 5 minutes and the aqueous phase was removed by separation to obtain a toluene solution of NBA.
  • 5
  • [ 2051-76-5 ]
  • [ 3119-15-1 ]
  • [ 98085-79-1 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; In methanol; at 100℃; for 4.0h; 10 g of <strong>[3119-15-1]3-amino-2,4,6-triiodobenzoic acid</strong> and 0.2 mL of concentrated sulfuric acid were added to 100 mL of methanol, and after stirring uniformly, the system was controlled at 20 C., and 30 mL of acrylic anhydride was slowly added dropwise.After the dropwise addition, the reaction was carried out at 100 C. for 4 hours. After the reaction was completed, the mixture was cooled to room temperature, washed with acetonitrile, and dried to obtain 3-acrylamido-2,4,6-triiodobenzoic acid.
 

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