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Chemical Structure| 2103-91-5 Chemical Structure| 2103-91-5

Structure of 2103-91-5

Chemical Structure| 2103-91-5

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Product Details of [ 2103-91-5 ]

CAS No. :2103-91-5
Formula : C10H10N2S
M.W : 190.26
SMILES Code : NC1=NC(C2=CC=C(C)C=C2)=CS1
MDL No. :MFCD00170264
InChI Key :ARLHWYFAPHJCJT-UHFFFAOYSA-N
Pubchem ID :244066

Safety of [ 2103-91-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Application In Synthesis of [ 2103-91-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2103-91-5 ]

[ 2103-91-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2103-91-5 ]
  • [ 80370-42-9 ]
  • 3-(4-methylphenyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin-6-carbaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
23.8 g In a reaction bottle with a water separator,Adding 19g of 4-(4-methylphenyl)-thiazol-2-amine and 17.5g of <strong>[80370-42-9]ethyl 2-formyl-3-oxopropionate</strong> to benzene (using benzene instead of toluene as solvent,Lowering the reaction reflux temperature, avoiding the formation of by-products in 200 mL, and adding 10 g of molecular sieve for drying,Slowly heating to reflux at 80 C, the water in the reaction system is removed during the reaction,Adding p-toluenesulfonic acid 1.7g to the reaction system under nitrogen protectionWhile maintaining the reaction mixture at reflux, continue to react for 6 h.Then, 60 mL of a methanol solution containing 11 g of sodium methoxide was slowly added dropwise under a nitrogen atmosphere.At the same time, the reaction system was kept at reflux and reacted for another 4 hours., TLC monitors the reaction of the raw materials completely, and distills off 100 mL of benzene under reduced pressure; Then the temperature of the reaction mixture slowly decreased to 0 to 10 C and stirring was continued for 1 h.Slowly add 25% hydrochloric acid at this temperature to adjust the pH of the reaction solution to neutral.During the dropwise addition of hydrochloric acid, a large amount of solids gradually precipitated, and stirring was continued at 0 to 10 C for 1 h.The reaction system is charged to analyze the solid, and the reaction solution is filtered.After the filter cake is dried, it is separated by silica gel column chromatography to obtain a solid.6-formyl-3-(4-methylphenyl)-5H-thiazolo[3,2-a]pyrimidin-5-one 23.8 g;
 

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