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[ CAS No. 2103-91-5 ]

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2D
Chemical Structure| 2103-91-5
Chemical Structure| 2103-91-5
Structure of 2103-91-5 *Storage: {[proInfo.prStorage]}

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Product Details of [ 2103-91-5 ]

CAS No. :2103-91-5MDL No. :MFCD00170264
Formula : C10H10N2S Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :190.26Pubchem ID :-
Synonyms :

Computed Properties of [ 2103-91-5 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 2103-91-5 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280UN#:N/A
Hazard Statements:H302-H312-H332Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2103-91-5 ]

  • Downstream synthetic route of [ 2103-91-5 ]

[ 2103-91-5 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 2103-91-5 ]
  • [ 614-23-3 ]
  • [ 112672-08-9 ]
YieldReaction ConditionsOperation in experiment
In acetone for 1h; Heating; Yield given;
  • 2
  • [ 2103-91-5 ]
  • [ 302964-02-9 ]
  • [ 1029088-56-9 ]
YieldReaction ConditionsOperation in experiment
17% With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 2-Chloro-l-methylpyridinium iodide (0.47 g, 1.84 mmol), DIEA (0.44 mL, 2.5 mmol) and 4-p- tolylthiazol-2-amine (0.24 g, 1.23 mmol) were added to a solution of 2-(tert- butoxycarbonylamino)thiazole-5-carboxylic acid (0.30 g, 1.23 mmol) in DMF (5 mL). The15 resulting solution was stirred at RT until completion of the reaction. Then the reaction mixture was diluted with AcOEt, washed with water, dried with Na2SO4 and concentrated. The crude product was purified by column (100% AcOEt), yielding tert-butyl 5-(4-p-tolylthiazol-2- ylcarbamoyl)thiazol-2-ylcarbamate (80 mg, 17%) as a solid. 1H-NMR (400 MHz, CDCl3): delta(ppm): 10.8 (bs, 2H), 7.76 (s, IH), 7.61 (d, J= 8 Hz, 2H), 7.15 0 (d, J= 8 Hz, 2 H), 7.09 (s, 1 H), 2.35 (s, 3H), 1.42 (s, 9H). MS (ESI): m/z (%): 417.32 [MH+].
  • 3
  • [ 2103-91-5 ]
  • [ 56651-60-6 ]
  • [ 1210115-24-4 ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium In tetrahydrofuran; hexane at 20℃; 1.) Synthesis of the urea derivatives General Procedure: To the residue was added dry tetrahydrofuran (THF, 1.5 ml). It was added dropwise to a solution of n-buthyllithium (0.80 mmol, 1.6 M in n-Hexane) deprotonated amine (0.80 mmol) in 1.5 ml tetrahydrofuran and stirred at room temperature overnight. The reaction solution was added to a vigorous stirred water to give the solid crude urea. The solid was filtered off and recrystallised from methanol or ethanol.
  • 4
  • [ 2103-91-5 ]
  • [ 2602-85-9 ]
  • N-(4-p-tolylthiazol-2-yl)benzo[d]thiazole-2-carboximidamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% In N,N-dimethyl-formamide; at 180℃; for 3h;Sealed tube; Microwave irradiation; Inert atmosphere; General procedure: 4.6. Microwave-assisted synthesis of N-(4-phenylthiazol-2-yl)-benzo[d]thiazole-, thiazolo[4,5-b]pyridine-, thiazolo[5,4-b]pyridine-, benzo[d]oxazole-2-carboximidamides (19e45)In a sealed tube, a stirred solution of carbonitrile (2 mmol) andthe appropriate 4-phenylthiazol-2-amine (2.4 mmol) in dry DMF(4 mL) was heated under microwave irradiation (800 W) at 180 Cfor 3 h. Evaporation of the solvent gave a crude product, which waspurified by flash chromatography using petroleum ether/methylenechloride (100:0 to 0:100, v/v) as eluent. 4.6.1. N-(4-Phenylthiazol-2-yl)benzo[d]thiazole-2-carboximidamide(19). Yield 80% (0.536 g), yellow solid, mp228e230 C; IR (cm1)ymax 3364, 3107, 2914, 1619, 1592, 1537, 1509, 1476, 1318, 1234, 1117,1044, 818, 766, 754, 726, 619; 1H NMR (300 MHz, DMSO-d6) d 9.54(br s, bs, 1H, NH), 9.26 (br s, 1H, NH), 8.25e8.19 (m, 1H, Har), 8.16 (d,J7.5 Hz, 1H, Har), 7.95 (d, J7.2 Hz, 2H, H-Ph), 7.84 (s, 1H, Hthiazole),7.68e7.55 (m, 2H, Har), 7.48 (t, J7.5 Hz, 2H, H-Ph), 7.37 (t, J7.3 Hz,1H, H-Ph); 13C NMR (75 MHz, DMSO-d6) d 173.2, 165.6, 153.7, 151.8,151.7, 136.9, 134.6, 129.4 (2C), 128.7, 127.6, 127.5, 126.3 (2C), 124.2,123.4, 110.6; HRMS calcd for C17H13N4S2 [MH] 337.0582, found337.0596.
  • 5
  • [ 2103-91-5 ]
  • [ 1878-49-5 ]
  • N-(4-(p-tolyl) thiazol-2-yl)-2-(2-methylphenoxy)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Phenoxyacetic acids (4a-j, 2mmol) in dry DCM (20ml) was stirred at 25-30C, and then lutidine (3mmol) was added, followed by the addition of substituted amino-4-phenyl-1,3-thiazoles (2mmol). The reaction mixture was stirred at the same temperature for 30min, then cooled to 0-5C and TBTU (2mmol) was added over a period of 30min maintaining the temperature below 5C. The reaction mass was stirred overnight and monitored by TLC using chloroform: methanol (9:1) as the mobile phase. The purity of the compounds was determined using high performance liquid chromatography (HPLC) by reversed phase agilent zorbax SB-C18 column method, with methanol (50%): acetonitrile (30%): water (20%) as mobile phase. The solvent was evaporated at reduced pressure, quenched by the addition of crushed ice and the obtained solid was filtered, dried and recrystallized from ethanol to afford compounds 8a-ab in good yield [supplementary files].
  • 6
  • [ 2103-91-5 ]
  • [ 25141-58-6 ]
  • 2-(2-isopropylphenoxy)-N-(4-(p-tolyl) thiazol-2-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Phenoxyacetic acids (4a-j, 2mmol) in dry DCM (20ml) was stirred at 25-30C, and then lutidine (3mmol) was added, followed by the addition of substituted amino-4-phenyl-1,3-thiazoles (2mmol). The reaction mixture was stirred at the same temperature for 30min, then cooled to 0-5C and TBTU (2mmol) was added over a period of 30min maintaining the temperature below 5C. The reaction mass was stirred overnight and monitored by TLC using chloroform: methanol (9:1) as the mobile phase. The purity of the compounds was determined using high performance liquid chromatography (HPLC) by reversed phase agilent zorbax SB-C18 column method, with methanol (50%): acetonitrile (30%): water (20%) as mobile phase. The solvent was evaporated at reduced pressure, quenched by the addition of crushed ice and the obtained solid was filtered, dried and recrystallized from ethanol to afford compounds 8a-ab in good yield [supplementary files].
  • 7
  • [ 2103-91-5 ]
  • [ 405-79-8 ]
  • 2-(4-fluorophenoxy)-N-(4-(p-tolyl) thiazol-2-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Phenoxyacetic acids (4a-j, 2mmol) in dry DCM (20ml) was stirred at 25-30C, and then lutidine (3mmol) was added, followed by the addition of substituted amino-4-phenyl-1,3-thiazoles (2mmol). The reaction mixture was stirred at the same temperature for 30min, then cooled to 0-5C and TBTU (2mmol) was added over a period of 30min maintaining the temperature below 5C. The reaction mass was stirred overnight and monitored by TLC using chloroform: methanol (9:1) as the mobile phase. The purity of the compounds was determined using high performance liquid chromatography (HPLC) by reversed phase agilent zorbax SB-C18 column method, with methanol (50%): acetonitrile (30%): water (20%) as mobile phase. The solvent was evaporated at reduced pressure, quenched by the addition of crushed ice and the obtained solid was filtered, dried and recrystallized from ethanol to afford compounds 8a-ab in good yield [supplementary files].
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