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[ CAS No. 21627-58-7 ] {[proInfo.proName]}

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Chemical Structure| 21627-58-7
Chemical Structure| 21627-58-7
Structure of 21627-58-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 21627-58-7 ]

CAS No. :21627-58-7 MDL No. :MFCD03563756
Formula : C10H14N2 Boiling Point : -
Linear Structure Formula :- InChI Key :BFPUBGCFJMIZDF-UHFFFAOYSA-N
M.W : 162.23 Pubchem ID :937501
Synonyms :

Safety of [ 21627-58-7 ]

Signal Word:Warning Class:
Precautionary Statements:P305+P351+P338 UN#:
Hazard Statements:H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 21627-58-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21627-58-7 ]

[ 21627-58-7 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 400743-82-0 ]
  • [ 20012-63-9 ]
  • [ 39643-31-7 ]
  • [ 728918-72-7 ]
  • C8H7F4N [ No CAS ]
  • C33H29IN5O4Pol [ No CAS ]
  • [ 91646-45-6 ]
  • [ 4273-98-7 ]
  • [ 2264-92-8 ]
  • [ 1204-44-0 ]
  • [ 68817-71-0 ]
  • [ 369-36-8 ]
  • [ 37750-29-1 ]
  • [ 55751-54-7 ]
  • [ 18595-14-7 ]
  • [ 52562-19-3 ]
  • [ 62532-99-4 ]
  • [ 21627-58-7 ]
  • [ 73818-73-2 ]
  • [ 54705-91-8 ]
  • [ 26286-54-4 ]
  • [ 177171-13-0 ]
  • [ 99-55-8 ]
  • [ 23491-48-7 ]
  • [ 400750-84-7 ]
  • C42H37N8O4Pol [ No CAS ]
  • C42H37N8O4Pol [ No CAS ]
  • C43H43N6O4Pol [ No CAS ]
  • C42H39N6O4Pol [ No CAS ]
  • C43H37N6O4PolS [ No CAS ]
  • C40H36N7O6Pol [ No CAS ]
  • C42H39N6O6Pol [ No CAS ]
  • C39H33FN7O6Pol [ No CAS ]
  • C44H39N6O5Pol [ No CAS ]
  • C45H38ClN6O4Pol [ No CAS ]
  • C46H41N6O4Pol [ No CAS ]
  • C43H42N7O4Pol [ No CAS ]
  • C46H41N6O5Pol [ No CAS ]
  • C45H38FN6O4Pol [ No CAS ]
  • C45H38ClN6O4Pol [ No CAS ]
  • C41H35F4N6O4Pol [ No CAS ]
  • C45H39N6O6PolS [ No CAS ]
  • C45H38ClN6O4PolS [ No CAS ]
  • C44H44N7O4Pol [ No CAS ]
  • C47H41N6O5Pol [ No CAS ]
  • C45H39ClN7O4Pol [ No CAS ]
  • C47H41N6O6Pol [ No CAS ]
  • C45H45N8O5Pol [ No CAS ]
  • C44H44N9O6Pol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ISOPROPYLAMIDE; at 60℃;Combinatorial reaction / High throughput screening (HTS); Step 2. Catalytic amination of the solid supported 8-iodo-l-methyl-4,5-dihydro- lH-pyrazolo [4,3-h] quinazoline-3-carboxamide; <n="82"/>Using a 4 niL Argonaut Trident synthesizer cassette, 200 mg (0.11 mmol) of the resin from step 1 above, were charged into separate vials. To each of the reactor vials flushed with argon, finely divided potassium carbonate (0.15 g, 1.1 mmol), palladium acetate [Pd(OAc)2] (2.5mg, 0.011 mmol, 10%), (HK)-BINAP (6.8 mg, 0.011 mmol, 10%) and the corresponding amine (0.22 mmol, 2 equivalents) in degassed (argon) dimethyacetamide (2 mL) were added. The resulting mixture was agitated at 600C for 10 hours on the Argonaut Trident Automated Library Synthesizer (ALS) station. The Trident ALS station was programmed to continuously mechanically agitate the resin at 6O0C while a nitrogen gas "sparge" was incorporated to re-suspend the scarcely soluble potassium carbonate. Nitrogen gas sparging was incorporated once per hour, for a 30 second duration, throughout the 16-hour heating cycle.The resin was drained from the synthesis cocktail and washed using the Argonaut Trident External Agitation Thermal Unit (EATU) synthesis station with DMA (3 x 2 mL, 5 min.). The above catalytic amination cycle was repeated a second time using the previously described procedure.Upon completion of the second amination cycle, the resin was drained from the synthesis cocktail and washed using the Argonaut Trident EATU synthesis station with DMF (1 x 2 mL, 5 min.), with water (1 x 2 mL, 5 min.), with DMF/water (1 : 1) (3 x 2 mL, 5 min.), with DMF (3 x 2 mL, 5 min.), with methanol (3 x 2 mL, 5 min.) and with DCM (3 x 2 mL, 5 min.).
  • 2
  • [ 405175-13-5 ]
  • [ 21627-58-7 ]
  • [ 1002158-47-5 ]
  • 3
  • [ 188014-56-4 ]
  • [ 21627-58-7 ]
  • [ 1392493-91-2 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;
  • 4
  • [ 20426-80-6 ]
  • [ 21627-58-7 ]
  • [ 1392493-59-2 ]
  • 5
  • [ 3508-94-9 ]
  • [ 21627-58-7 ]
  • [ 1392493-44-5 ]
  • 6
  • [ 1578-63-8 ]
  • [ 21627-58-7 ]
  • [ 1392493-42-3 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;
  • 7
  • [ 29645-00-9 ]
  • [ 21627-58-7 ]
  • [ 1392494-07-3 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;
  • 8
  • [ 658-93-5 ]
  • [ 21627-58-7 ]
  • [ 1392493-70-7 ]
  • 9
  • [ 49609-84-9 ]
  • [ 21627-58-7 ]
  • 2-chloro-N-(2-(pyrrolidin-1-yl)phenyl)nicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% Stage #1: 2-(pyrrolidin-1-yl)-phenylamine With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 2-Chloronicotinoyl chloride In dichloromethane for 0.5h; 3.2.3. Synthesis of Compounds III: 2-Chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide (1b) General procedure: A solution of 2-(piperidin-1-yl)aniline (0.2 g, 0.025 mol), dichloromethane (25 mL) and triethylamine (0.5 mL) was added to a 50 mL flask and cooled to 0 °C in an ice bath. After ten minutes, 2-chloronicotinoyl chloride (0.22 g) was added [20,21]. The mixture was stirred for 30 min, and then concentrated under reduced pressure to give a crude product. The pure 2-chloro-N-(2-(piperidin-1-yl)phenyl) nicotinamide (1b) was obtained by column chromatography (EtOAc:PE = 8:1) purification yield 88%;
  • 10
  • [ 58757-38-3 ]
  • [ 21627-58-7 ]
  • 6-chloro-N-(2-(pyrrolidin-1-yl)phenyl)nicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% Stage #1: 2-(pyrrolidin-1-yl)-phenylamine With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 6-Chloronicotinoyl chloride In dichloromethane for 0.5h; 3.2.3. Synthesis of Compounds III: 2-Chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide (1b) General procedure: A solution of 2-(piperidin-1-yl)aniline (0.2 g, 0.025 mol), dichloromethane (25 mL) and triethylamine (0.5 mL) was added to a 50 mL flask and cooled to 0 °C in an ice bath. After ten minutes, 2-chloronicotinoyl chloride (0.22 g) was added [20,21]. The mixture was stirred for 30 min, and then concentrated under reduced pressure to give a crude product. The pure 2-chloro-N-(2-(piperidin-1-yl)phenyl) nicotinamide (1b) was obtained by column chromatography (EtOAc:PE = 8:1) purification yield 88%;
  • 11
  • [ 698-00-0 ]
  • [ 21627-58-7 ]
  • C18H23N3 [ No CAS ]
  • 12
  • [ 150560-58-0 ]
  • [ 21627-58-7 ]
  • 5-isopropyl-2',3',3a',5'-tetrahydro-1'H-spiro[indoline-3,4'-pyrrolo[1,2-a]quinoxalin]-2-one [ No CAS ]
  • 13
  • [ 18711-15-4 ]
  • [ 21627-58-7 ]
  • 4,6-dichloro-2',3',3a',5'-tetrahydro-1'H-spiro[indoline-3,4'-pyrrolo[1,2-a]quinoxalin]-2-one [ No CAS ]
  • 14
  • [ 40133-07-1 ]
  • [ 21627-58-7 ]
  • N-(2-(pyrrolidin-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide [ No CAS ]
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