630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Boronic acids/esters >>1,3,2-DioxaborinaneAliphatic BoronsAromatic BoronsBCATBoric AcidsMIDA BoronatesOther BoronatesOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl ChloridesAlcohols
AldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic LiquidsSolid Supported SynthesisStains and Dyes >>
Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Material OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Organic Building Blocks
Bromides
Bromoacetyl chloride
Chemistry
Pharmaceutical Intermediate
Organic Building Blocks
CNS Agents
Bromides
Acyl Chlorides Ponesimod Related Fingolimod Hydrochloride

[ CAS No. 22118-09-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 22118-09-8
Chemical Structure| 22118-09-8
Structure of 22118-09-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 22118-09-8 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 22118-09-8 ]

SDS Specification
Alternatived Products of [ 22118-09-8 ]
Product Citations

Product Details of [ 22118-09-8 ]

CAS No. :22118-09-8 MDL No. :MFCD00000724
Formula : C2H2BrClO Boiling Point : -
Linear Structure Formula :CH2BrC(O)Cl InChI Key :SYZRZLUNWVNNNV-UHFFFAOYSA-N
M.W : 157.39 Pubchem ID :89602
Synonyms :

Safety of [ 22118-09-8 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P280-P305+P351+P338-P310 UN#:3265
Hazard Statements:H314-H335 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 22118-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22118-09-8 ]

[ 22118-09-8 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 110-91-8 ]
  • [ 22118-09-8 ]
  • [ 40299-87-4 ]
YieldReaction ConditionsOperation in experiment
28% With triethylamine; In dichloromethane; at 0 - 20℃;Inert atmosphere; Under the protection of argon, Weigh morpholine (600 muL, 6.9 mmol) in anhydrous dichloromethane (8 mL), Triethylamine (960 muL, 6.9 mmol) was sequentially added dropwise at 0 C. A solution of 2-bromoacetyl chloride (580 muL, 6.9 mmol) in anhydrous dichloromethane (4 mL), Stir overnight at room temperature. After the reaction was completed, water (15 mL) was added to the reaction solution. Extracted with dichloromethane (15 mL x 2), Washed with saturated sodium bicarbonate (8mL x 2) and saturated sodium chloride (10mL x 1), Dry over anhydrous sodium sulfate and evaporate the solvent under reduced pressure. The residue containing compound 97-1 was used directly in the next step without further reaction.
With triethylamine; In dichloromethane; at -25 - 20℃; for 4.75h;Inert atmosphere; flask is charged with bromoacetyl bromide (25 mL), dichloromethane (500 mL) and mixture is stirred under nitrogen atmosphere. The reaction mixture is cooled to -25C followed by slow addition of morpholine (72.7 mL in 500 mL of DCM) at the same temperature over a period of 30 minutes. The reaction mixture is stirred at -25C for 15 minutes, then allowed to attain room temperature at which it is further stirred for 4 hours. The completion of the reaction is monitored by TLC and reaction mixture is sequentially washed with water (2x250 mL) and brine solution (2x100 mL). The organic solvent is subjected to distillation to afford the title compound.
Reference： [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 20 - 24
[2]Patent: CN110627817,2019,A .Location in patent: Paragraph 0755-0758
[3]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1972,vol. 21,p. 2548 - 2549
    Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1972,vol. 21,p. 2613 - 2614
[4]Patent: WO2016/1851,2016,A1 .Location in patent: Page/Page column 23
  • 2
  • [ 22118-09-8 ]
  • [ 1986-47-6 ]
  • [ 133941-07-8 ]
Reference： [1]Journal of Pharmaceutical Sciences,1991,vol. 80,p. 255 - 261
  • 3
  • [ 22118-09-8 ]
  • [ 6519-67-1 ]
  • [ 160061-62-1 ]
Reference： [1]Heterocycles,1994,vol. 38,p. 2051 - 2064
  • 4
  • [ 22118-09-8 ]
  • [ 525-03-1 ]
  • [ 1026419-39-5 ]
Reference： [1]Journal of the American Chemical Society,2003,vol. 125,p. 9588 - 9589
[2]Journal of Medicinal Chemistry,2010,vol. 53,p. 2482 - 2493
[3]Proceedings of the National Academy of Sciences of the United States of America,2010,vol. 107,p. 4573 - 4578
  • 5
  • [ 22118-09-8 ]
  • [ 98-16-8 ]
  • [ 25625-57-4 ]
YieldReaction ConditionsOperation in experiment
64% With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0℃; for 1h; 3-Trifluoromethylaniline (1.6 g, 10 mmol) was dissolved in dichloromethane with DIEA (3.4 mL, 20 mmol), cooled to 0 C, and to this solution bromoacetyl chloride was added as a neat liquid (exothermic). After 1 hour the reaction mixture was washed with IN HCl, dried and concentrated to a brown oil which was purified by column chromatography (10 to 40 % EtOAc/liexanes) to give a light brown oil, 1.8 g, 6.4 mmol, 64% YIELD. 1H NMR (500 MHz, CDC13) S 8. 19 (S, 1H), 7.75 (s, 1H), 7.68 (d, J = 8.1 Hz, 1H), 7.41 (t, J = 7.9 Hz, 1H), 7.35 (d, J = 7.8 HZ,, 3. 96 (s, 2H).
Reference： [1]Patent: WO2005/19190,2005,A2 .Location in patent: Page/Page column 59
[2]Journal of Medicinal Chemistry,2006,vol. 49,p. 7450 - 7465
[3]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 1409 - 1419
[4]ACS Medicinal Chemistry Letters,2016,vol. 7,p. 235 - 239
  • 6
  • [ 22118-09-8 ]
  • [ 66655-67-2 ]
  • 6-(Bromoacetyl)-3,4-dihydro-2(1H)-quinazolinone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride;aluminium trichloride; In carbon disulfide; Step 1 6-(Bromoacetyl)-<strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> Bromoacetyl chloride (6.2 g) is added dropwise to a stirring mixture of <strong>[66655-67-2]3,4-dihydro-2(1H)-quinazolinone</strong> (2.6 g) and anhydrous aluminum chloride (6.3 g) in carbon disulfide (60 ml). The reaction mixture is stirred under reflux for 4.5 hours, the carbon disulfide decanted, and the residue treated with HCl (6N). The resulting solid is poured into ice water, filtered, the filtered solid washed with water and dried in vacuo, affording the desired product, which is used in the next step without further purification.
Reference： [1]Patent: US4666913,1987,A
  • 7
  • [ 22118-09-8 ]
  • [ 1022-13-5 ]
  • N-methyl-(2-benzoyl-4-chloro)-phenyl bromoacetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% In ethyl acetate; Petroleum ether; benzene; (d) Production of N-methyl-(2-benzoyl-4-chloro)-phenyl bromoacetamide A solution of 2-methylamino-5-chlorobenzophenone in a mixture of 200 cc of benzene and 100 cc of ether is chilled to 0° C., followed by the dropwise addition over a period of 25 minutes of 5.8 cc of bromoacetyl chloride in solution in 40 cc of ether. After standing overnight while stirring at room temperature, the mixture is evaporated to dryness. The oily residue triturated in petroleum ether crystallises rapidly. The crystals are filtered, washed with petroleum ether, dissolved in ethylacetate and decoloured with animal charcoal. After filtration and concentration, precipitation with petroleum ether and filtration, 19.3 g of product are recovered. Yield: 82percent. Melting point: 90° C. Plate chromatography: support: silica gel 60 F 254 Merck solvent: ethylacetate/petroleum ether 25/75 development: UV and iodine Rf: 0.43.
Reference： [1]Patent: US4372975,1983,A

Tags: 22118-09-8 synthesis path| 22118-09-8 SDS| 22118-09-8 COA| 22118-09-8 purity| 22118-09-8 application| 22118-09-8 NMR| 22118-09-8 COA| 22118-09-8 structure

Recommend Products
Same Skeleton Products
Related Products
Isomers
Categories
Chemistry
Organic Building Blocks
Acyl Chlorides
Chemistry
Organic Building Blocks
Bromides
Pharmaceutical Intermediate
CNS Agents
Fingolimod Hydrochloride
Pharmaceutical Intermediate
CNS Agents
Ponesimod Related

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Catalytic Hydrogenation • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Rosenmund Reduction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling
Historical Records
; ;