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Chemical Structure| 22265-77-6 Chemical Structure| 22265-77-6

Structure of 22265-77-6

Chemical Structure| 22265-77-6

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Product Details of [ 22265-77-6 ]

CAS No. :22265-77-6
Formula : C9H12N2S
M.W : 180.27
SMILES Code : S=C(N)NC1=CC=CC=C1CC
MDL No. :MFCD00041373

Safety of [ 22265-77-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P501-P270-P264-P301+P310+P330-P405
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 22265-77-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22265-77-6 ]

[ 22265-77-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 26346-85-0 ]
  • [ 22265-77-6 ]
  • 4-(2,4-dimethylphenyl)-N-(2-ethylphenyl)-1,3-thiazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% In ethanol; at 20℃; for 1.5h; To a solution of 2-bromo-1-(2,4-dimethyl-thiazol-5-yl)ethanone in ethanol was added N-phenyl-thiourea. The resulting solution was stirred at room temperature for 30 minutes to overnight, followed by removal of ethanol under reduced pressure. The residue thus obtained was treated with saturated NaHCO3(aq) solution and extracted with CH2Cl2. Organic layers were combined, washed with brine, dried over MgSO4(s), filtered, and concentrated to afford a residue. The residue was purified by Isco Combi-Flash Companion column chromatography to give the desired product. <strong>[26346-85-0]2-bromo-1-(2,4-dimethylphenyl)ethanone</strong> (130 mg, 0.572 mmol), ethanol (3.0 mL), and 1-(2-ethylphenyl)thiourea (93.8 mg, 0.520 mmol) were used to carry out the reaction. After the solution was stirred for 1.5 h and work-up, the residue was purified by Isco Combi-Flash Companion column chromatography (0-7% EtOAc in n-hexane) to give 4-(2,4-dimethylphenyl)-N-(2-ethylphenyl)-1,3-thiazol-2-amine (122 mg, 76%) as a yellow solid. 1H NMR (CDCl3, 400 MHz) δ 7.67 (d, 1H), 7.48 (d, 1H), 7.28-7.22 (m, 2H), 7.13 (dd, 1H), 7.10-7.03 (m, 2H), 6.48 (s, 1H), 2.68 (q, 2H), 2.45 (s, 3H), 2.34 (s, 3H), 1.25 (t, 3H); LC-MS (APCI) m/z: 309.2 [M+H]+.
 

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