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Chemical Structure| 2381-75-1 Chemical Structure| 2381-75-1

Structure of 2381-75-1

Chemical Structure| 2381-75-1

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Product Details of [ 2381-75-1 ]

CAS No. :2381-75-1
Formula : C8H9ClN2O2
M.W : 200.62
SMILES Code : O=C(NN)COC1=CC=C(Cl)C=C1
MDL No. :MFCD00705185

Safety of [ 2381-75-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P301+P312+P330

Application In Synthesis of [ 2381-75-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2381-75-1 ]

[ 2381-75-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2905-56-8 ]
  • [ 6160-65-2 ]
  • [ 2381-75-1 ]
  • [ 1489288-71-2 ]
YieldReaction ConditionsOperation in experiment
74% To a suspension of TCDI (230mg, 1.29mmol, 1.1eq) in anhydrous THF (2.6mL) was added the hydrazide 2q (235mg, 1.17mmol, 1eq) and the reaction mixture was refluxed for 24h. The reaction mixture was cooled, the amine N-methyl-(4-phenylbutyl)amine (246mg, 1.23mmol, 1.05eq) was added and the reaction mixture was stirred for a further 72h. The crude reaction mixture was diluted with EtOAc and washed with 1N HCl, H2O, brine, dried (MgSO4) and concentrated. The residue was purified by flash chromatography on silica gel (cyclohexane/EtOAc 1:0 to 1:1 (v/v)) to afford the desired compound (106mg). White powder.
  • 2
  • [ 1878-91-7 ]
  • [ 2381-75-1 ]
  • [ 944529-34-4 ]
 

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