Home Cart 0 Sign in  
X

[ CAS No. 24484-96-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 24484-96-6
Chemical Structure| 24484-96-6
Chemical Structure| 24484-96-6
Structure of 24484-96-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 24484-96-6 ]

Related Doc. of [ 24484-96-6 ]

Alternatived Products of [ 24484-96-6 ]

Product Details of [ 24484-96-6 ]

CAS No. :24484-96-6 MDL No. :MFCD04973545
Formula : C5H4ClN3O2 Boiling Point : -
Linear Structure Formula :- InChI Key :LHFAJLRJEULFIT-UHFFFAOYSA-N
M.W : 173.56 Pubchem ID :5150686
Synonyms :

Calculated chemistry of [ 24484-96-6 ]

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 42.47
TPSA : 84.73 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.68 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.72
Log Po/w (XLOGP3) : 0.96
Log Po/w (WLOGP) : 1.23
Log Po/w (MLOGP) : -0.29
Log Po/w (SILICOS-IT) : -0.77
Consensus Log Po/w : 0.37

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.86
Solubility : 2.4 mg/ml ; 0.0139 mol/l
Class : Very soluble
Log S (Ali) : -2.33
Solubility : 0.818 mg/ml ; 0.00471 mol/l
Class : Soluble
Log S (SILICOS-IT) : -1.66
Solubility : 3.81 mg/ml ; 0.0219 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.03

Safety of [ 24484-96-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 24484-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 24484-96-6 ]
  • Downstream synthetic route of [ 24484-96-6 ]

[ 24484-96-6 ] Synthesis Path-Upstream   1~16

  • 1
  • [ 13091-23-1 ]
  • [ 1681-37-4 ]
  • [ 6980-08-1 ]
  • [ 40497-64-1 ]
  • [ 24484-96-6 ]
Reference: [1] Liebigs Annalen der Chemie, 1991, # 9, p. 875 - 878
  • 2
  • [ 13091-23-1 ]
  • [ 1681-37-4 ]
  • [ 40497-64-1 ]
  • [ 24484-96-6 ]
Reference: [1] Liebigs Annalen der Chemie, 1991, # 9, p. 875 - 878
  • 3
  • [ 19798-80-2 ]
  • [ 6980-08-1 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
37%
Stage #1: at -8 - 20℃; for 0.333333 h; Salt-ice bath
Stage #2: With ammonia In water at 0 - 25℃;
Example 13(a) 4-Chloro-3-nitropyridin-2-amine(Aust. J. Chem. 1982, 35, 2025.)4-Chloro-2-aminopyridine (10 g, 77.5 mmol) was dissolved in concentrated sulfuric acid (10OmL) and using a salt-ice bath, was cooled to ca. -8 0C. Fuming nitric acid was slowly added whilst stirring and at such a rate that a temperature < 0 °C was maintained. The reaction mixture was then stirred for 20 minutes at ambient temperature and carefully poured onto ice. Ammonium hydroxide (32percent) was carefully added. Ice was used to maintain temperature < 25 0C until the solution reached pH 3. The solid product was filtered, washed with water and re-crystallised from 1:1 wateπEtOH. The solid was added in small portions to ice-cold concentrated sulfuric acid (200 mL) at a rate allowing a temperature of <4 °C to be maintained. Once addition was complete, the reaction mixture was allowed to reach ambient temperature. After 2.5 h at room temperature, 2 regioisomers (1:1), the 3 and 5-nitro compounds were observed (LCMS). The reaction mixture was poured onto ice and basifed with ammonium hydroxide (32percent). Filtration and subsequent washing with water provided the mixture of the 2 regioisomers. The products were dissolved in ethyl acetate to which was added heptane to effect trituration of the undesired regioisomer. Filtration of this isomer and evaporation of the ethyl acetate provided the desired product along with 15-20percent of the undesired isomer. These isomers could also be separated using silica flash chromatography (Combiflash.(R). system) with a suitable EtOAC/heptane gradient. (5 g, 37 percent). MS (ESI) m/z 172 (M-I), 174. RT (LCMS, 254nm) 2.2 min
32%
Stage #1: for 0.0833333 h; Cooling with ice
Stage #2: at 0 - 55℃; for 1.16667 h;
To a 100 ml round-bottomed flask containing 2-amino-4-chloropyridine (0.480g, 3.75 mmol) cooled in an ice bath was added concentrated sulphuric acid (5.4 g). Thereaction mixture was stirred for 5 min and then nitric acid (70percent; 0.36 g) was addeddropwise. The reaction mixture was stirred at 0 °C for 10 min, then heated to 55 °C andstirred at this temperature for 1 h. It was cooled to room temperature and diluted with ice-1 0 water. The pH was carefully adjusted to ~ 7.5 with 10percent aqueous NaOH whereupon ayellow precipitate formed. This was filtered off, washed with water and dried in vacuoover P205. The product was purified by silica column chromatography (elution withdichloromethane) to provide in order of elution: 4-Chloro-3-nitropyridin-2-amine as ayellow solid (0.21 0 g, 32percent), 1 H-NMR (500 MHz, DMSO-d6) 6.87 (d, J = 5.2 Hz, 1 H,15 pyridine C-H), 7.21 (s, 2H, NH2), 8.11 (d, J = 5.2 Hz, 1 H, pyridine C-H). [00118] 4-chloro-5-nitropyridin-2-amine (0.080 g, 12percent): 1H-NMR (500 MHz, DMSO-d6)6.58 (s, 1 H, pyridine C-H) 7.58 (s, 2H, NH2), 8.79 (s, 1 H, pyridine C-H).
Reference: [1] Tetrahedron Letters, 2012, vol. 53, # 42, p. 5597 - 5601
[2] Patent: WO2007/40438, 2007, A2, . Location in patent: Page/Page column 59
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[5] Patent: WO2013/190320, 2013, A1, . Location in patent: Paragraph 00117; 00118
[6] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 8, p. 2512 - 2515
  • 4
  • [ 24484-97-7 ]
  • [ 6980-08-1 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
1.47 g at 0 - 20℃; for 3 h; The compounds were prepared as described in the literature with major modifications. To a solution of 4-chloropyridin-2-amine 9 (2.60 g, 0.02 mol) in sulfuric acid (96percent, 40 mL) was slowly added fuming nitric acid (20 mL) under intensively stirring at 0 C over a period of 6 h. The reaction mixture was allowed to stay at 0-5 C for 3 days and then poured into ice water (120 g).The mixture was adjusted to pH 3-5 with ammonium hydroxide (25percent, 160 mL) and the yellow precipitate filtered, washed with cooled water, and dried at room temperature to give 4-chloro-2-nitraminopyridine intermediate (3.46 g, 99percent) as yellow crystals; mp 204-205 C. The crude nitramine (2.73 g, 0.016 mol) was carefully dissolved in small portions into cooled sulfuric acid (96percent,54 mL) under constant stirring. The solution was allowed to warm to room temperature and stirred for further 3 h. After that, the reaction mixture was poured into ice water (60 g) and adjusted topH 6-7 with ammonium hydroxide (25percent, 150 mL) until a yellow crystalline precipitate was formed. The cooled product (mixture of 3- and 5-nitro isomers) was filtered under normal pressure, dried at room temperature over night, and washed several times with ethyl acetate (170 mL) until the color of the crystalline precipitate had turned to a slight yellow. The residue left after filtration was dissolved in ethanol (100 mL), boiled for 15 min, filtered to removethe insoluble precipitate, and recrystallized from dichloromethane/petroleum ether (50percent, 50 mL) to give the pure product 11 (Fraction 1). The combined ethyl acetate layers were evaporated to dryness and purified by repeated column chromatography on silica gel using 50percent dichloromethane/ethyl acetate as eluent. Chromatographically purified products were additionally recrystallized from dichloromethane/petroleum ether (50percent, each 50 mL), evaporated, and dried at 70 C to give pure product 10 (Fractions 2and 4) and 11 (Fraction 3, for details, see Supplementary data,Fig. S2).4.2.1. 4-Chloro-3-nitropyridin-2-amine (10). Slight yellow needles (1.47 g, 42percent over two steps); mp 176-177 C; Rf (50percent CH2Cl2/EtOAc) 0.69; 1H NMR (500 MHz, DMSO-d6) dH: 6.85 (1H, d,J5.36 Hz, H-5), 7.21 (2H, br s, NH2), 8.11 (1H, d, J5.36 Hz, H-6); 13CNMR (125 MHz, DMSO-d6) dC: 113.2 (C5), 129.5 (C3), 136.0 (C4),152.1 (C6), 152.8 (C2); LC/ESI-MS calcd for C5H4ClN3O2 m/z 173.0,found 171.9 [MH]e, 174.9 [MH].4.2.2. 4-Chloro-5-nitropyridin-2-amine (11).22b Yellow crystals(1.05 g, 30percent over two steps); mp 260-261 C; Rf (50percent CH2Cl2/EtOAc)0.48; 1H NMR (500 MHz, DMSO-d6) dH: 6.58 (1H, s, H-3), 7.59 (2H,br s, NH2), 8.79 (1H, s, H-6); 13C NMR (125 MHz, DMSO-d6) dC: 108.4(C3), 133.5 (C5), 137.1 (C4), 149.7 (C6), 162.7 (C2); LC/ESI-MS calcd for C5H4ClN3O2 m/z 173.0, found 171.9 [MH]
Reference: [1] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034
[2] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2035 - 2040
[3] Tetrahedron, 2016, vol. 72, # 41, p. 6455 - 6466
  • 5
  • [ 13091-23-1 ]
  • [ 1681-37-4 ]
  • [ 6980-08-1 ]
  • [ 40497-64-1 ]
  • [ 24484-96-6 ]
Reference: [1] Liebigs Annalen der Chemie, 1991, # 9, p. 875 - 878
  • 6
  • [ 24484-96-6 ]
  • [ 4487-56-3 ]
YieldReaction ConditionsOperation in experiment
33% With hydrogenchloride; sodium nitrite In water at 0 - 25℃; for 51 h; To 4-chloro-5-nitropyridine-2-amine (Method 92, 4.40 g, 21.0 mmol) in concentrated HCl (70 ml) was added sodium nitrite (4.36 g, 63.1 mmol) potion wise at 0-5 0C. After 1 hour at 0-5 °C, the reaction was warmed to room temperature and stirred for 50 hours. Ice (100 g) was added and the mixture was extracted wit ether (2x50 ml) and dried over sodium sulfate. The solvent was removed under reduced pressure and the resulted residue was purified by column chromatography (hexane-DCM = 1 : 5) to give the title compound as a white solid (1.47 g, 33percent). 1H NMR (400 MHz) 9.18 (s, IH), 8.22 (s, IH).
Reference: [1] Patent: WO2006/87530, 2006, A1, . Location in patent: Page/Page column 73
  • 7
  • [ 19798-80-2 ]
  • [ 6980-08-1 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
37%
Stage #1: at -8 - 20℃; for 0.333333 h; Salt-ice bath
Stage #2: With ammonia In water at 0 - 25℃;
Example 13(a) 4-Chloro-3-nitropyridin-2-amine(Aust. J. Chem. 1982, 35, 2025.)4-Chloro-2-aminopyridine (10 g, 77.5 mmol) was dissolved in concentrated sulfuric acid (10OmL) and using a salt-ice bath, was cooled to ca. -8 0C. Fuming nitric acid was slowly added whilst stirring and at such a rate that a temperature < 0 °C was maintained. The reaction mixture was then stirred for 20 minutes at ambient temperature and carefully poured onto ice. Ammonium hydroxide (32percent) was carefully added. Ice was used to maintain temperature < 25 0C until the solution reached pH 3. The solid product was filtered, washed with water and re-crystallised from 1:1 wateπEtOH. The solid was added in small portions to ice-cold concentrated sulfuric acid (200 mL) at a rate allowing a temperature of <4 °C to be maintained. Once addition was complete, the reaction mixture was allowed to reach ambient temperature. After 2.5 h at room temperature, 2 regioisomers (1:1), the 3 and 5-nitro compounds were observed (LCMS). The reaction mixture was poured onto ice and basifed with ammonium hydroxide (32percent). Filtration and subsequent washing with water provided the mixture of the 2 regioisomers. The products were dissolved in ethyl acetate to which was added heptane to effect trituration of the undesired regioisomer. Filtration of this isomer and evaporation of the ethyl acetate provided the desired product along with 15-20percent of the undesired isomer. These isomers could also be separated using silica flash chromatography (Combiflash.(R). system) with a suitable EtOAC/heptane gradient. (5 g, 37 percent). MS (ESI) m/z 172 (M-I), 174. RT (LCMS, 254nm) 2.2 min
32%
Stage #1: for 0.0833333 h; Cooling with ice
Stage #2: at 0 - 55℃; for 1.16667 h;
To a 100 ml round-bottomed flask containing 2-amino-4-chloropyridine (0.480g, 3.75 mmol) cooled in an ice bath was added concentrated sulphuric acid (5.4 g). Thereaction mixture was stirred for 5 min and then nitric acid (70percent; 0.36 g) was addeddropwise. The reaction mixture was stirred at 0 °C for 10 min, then heated to 55 °C andstirred at this temperature for 1 h. It was cooled to room temperature and diluted with ice-1 0 water. The pH was carefully adjusted to ~ 7.5 with 10percent aqueous NaOH whereupon ayellow precipitate formed. This was filtered off, washed with water and dried in vacuoover P205. The product was purified by silica column chromatography (elution withdichloromethane) to provide in order of elution: 4-Chloro-3-nitropyridin-2-amine as ayellow solid (0.21 0 g, 32percent), 1 H-NMR (500 MHz, DMSO-d6) 6.87 (d, J = 5.2 Hz, 1 H,15 pyridine C-H), 7.21 (s, 2H, NH2), 8.11 (d, J = 5.2 Hz, 1 H, pyridine C-H). [00118] 4-chloro-5-nitropyridin-2-amine (0.080 g, 12percent): 1H-NMR (500 MHz, DMSO-d6)6.58 (s, 1 H, pyridine C-H) 7.58 (s, 2H, NH2), 8.79 (s, 1 H, pyridine C-H).
Reference: [1] Tetrahedron Letters, 2012, vol. 53, # 42, p. 5597 - 5601
[2] Patent: WO2007/40438, 2007, A2, . Location in patent: Page/Page column 59
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[5] Patent: WO2013/190320, 2013, A1, . Location in patent: Paragraph 00117; 00118
[6] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 8, p. 2512 - 2515
  • 8
  • [ 19798-80-2 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
41% at 0 - 20℃; 4-Chloropyridin-2-amine (4) (5.2g, 40.6mmol) was carefully dissolved in conc. sulfuric acid (25mL). The reaction mixture was cooled to 0°C and then fuming nitric acid (1.5mL) was added dropwise with stirring. The reaction mixture was allowed to stand for overnight at room temperature, or until a drop mixed with water, gave no precipitate (the nitro-amine is insoluble in dilute acid). The red reaction mixture was then poured into crushed ice and bought to pH 5–6 by adding ammonia solution (28percent). The separated yellow precipitate was removed by filtration, washed well with ice water and dried. The solids were impregnated onto silica gel and purified by flash chromatography (EtOAc : petroleum ether=1:1) to give compound 4-chloro-5-nitropyridin-2-amine (5) as a yellow solid [28,29]. Yield: 2.88g, 41percent, mp: 257–259°C. 1H NMR (DMSO-d6, ppm) δ: 8.81 (s, 1H, CH), 7.76 (s, 1H, CH), 6.59 (s, 2H, NH2). ESI-MS: m/z 174.3 (M+1), C5H4ClN3O2 [173.00].
Reference: [1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 531 - 538
[2] Tetrahedron, 2016, vol. 72, # 41, p. 6455 - 6466
  • 9
  • [ 13091-23-1 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
33% at -33 - 20℃; for 5 h; To 4-chloro-3-nitropyridine (10.0 g, 63.1 mmol) in 500 ml of liquid ammonium was added potassium permanganate (19.9 g, 126.1 mmol). The reaction was stirred at this temperature (-33 0C) for 5 hours then slowly warmed to room temperature. After evaporation of ammonia, water (1 L) was added. The solid formed was collected by filtration and washed with water (2 L). The solid was extracted with 1 : l=DCM:EtOAc (5x500 ml). The solvent was removed and the resulting solid was recrystallized from EtOAc (400 ml) to give the title compound as a yellow solid (4.4 g, 33percent). 1HNMR (400 MHz) 8.88 (s, IH), 7.65 (b, 2H), 6.62 (s, IH).
Reference: [1] Patent: WO2006/87530, 2006, A1, . Location in patent: Page/Page column 73
  • 10
  • [ 24484-97-7 ]
  • [ 6980-08-1 ]
  • [ 24484-96-6 ]
YieldReaction ConditionsOperation in experiment
1.47 g at 0 - 20℃; for 3 h; The compounds were prepared as described in the literature with major modifications. To a solution of 4-chloropyridin-2-amine 9 (2.60 g, 0.02 mol) in sulfuric acid (96percent, 40 mL) was slowly added fuming nitric acid (20 mL) under intensively stirring at 0 C over a period of 6 h. The reaction mixture was allowed to stay at 0-5 C for 3 days and then poured into ice water (120 g).The mixture was adjusted to pH 3-5 with ammonium hydroxide (25percent, 160 mL) and the yellow precipitate filtered, washed with cooled water, and dried at room temperature to give 4-chloro-2-nitraminopyridine intermediate (3.46 g, 99percent) as yellow crystals; mp 204-205 C. The crude nitramine (2.73 g, 0.016 mol) was carefully dissolved in small portions into cooled sulfuric acid (96percent,54 mL) under constant stirring. The solution was allowed to warm to room temperature and stirred for further 3 h. After that, the reaction mixture was poured into ice water (60 g) and adjusted topH 6-7 with ammonium hydroxide (25percent, 150 mL) until a yellow crystalline precipitate was formed. The cooled product (mixture of 3- and 5-nitro isomers) was filtered under normal pressure, dried at room temperature over night, and washed several times with ethyl acetate (170 mL) until the color of the crystalline precipitate had turned to a slight yellow. The residue left after filtration was dissolved in ethanol (100 mL), boiled for 15 min, filtered to removethe insoluble precipitate, and recrystallized from dichloromethane/petroleum ether (50percent, 50 mL) to give the pure product 11 (Fraction 1). The combined ethyl acetate layers were evaporated to dryness and purified by repeated column chromatography on silica gel using 50percent dichloromethane/ethyl acetate as eluent. Chromatographically purified products were additionally recrystallized from dichloromethane/petroleum ether (50percent, each 50 mL), evaporated, and dried at 70 C to give pure product 10 (Fractions 2and 4) and 11 (Fraction 3, for details, see Supplementary data,Fig. S2).4.2.1. 4-Chloro-3-nitropyridin-2-amine (10). Slight yellow needles (1.47 g, 42percent over two steps); mp 176-177 C; Rf (50percent CH2Cl2/EtOAc) 0.69; 1H NMR (500 MHz, DMSO-d6) dH: 6.85 (1H, d,J5.36 Hz, H-5), 7.21 (2H, br s, NH2), 8.11 (1H, d, J5.36 Hz, H-6); 13CNMR (125 MHz, DMSO-d6) dC: 113.2 (C5), 129.5 (C3), 136.0 (C4),152.1 (C6), 152.8 (C2); LC/ESI-MS calcd for C5H4ClN3O2 m/z 173.0,found 171.9 [MH]e, 174.9 [MH].4.2.2. 4-Chloro-5-nitropyridin-2-amine (11).22b Yellow crystals(1.05 g, 30percent over two steps); mp 260-261 C; Rf (50percent CH2Cl2/EtOAc)0.48; 1H NMR (500 MHz, DMSO-d6) dH: 6.58 (1H, s, H-3), 7.59 (2H,br s, NH2), 8.79 (1H, s, H-6); 13C NMR (125 MHz, DMSO-d6) dC: 108.4(C3), 133.5 (C5), 137.1 (C4), 149.7 (C6), 162.7 (C2); LC/ESI-MS calcd for C5H4ClN3O2 m/z 173.0, found 171.9 [MH]
Reference: [1] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034
[2] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2035 - 2040
[3] Tetrahedron, 2016, vol. 72, # 41, p. 6455 - 6466
  • 11
  • [ 13091-23-1 ]
  • [ 1681-37-4 ]
  • [ 6980-08-1 ]
  • [ 40497-64-1 ]
  • [ 24484-96-6 ]
Reference: [1] Liebigs Annalen der Chemie, 1991, # 9, p. 875 - 878
  • 12
  • [ 24484-93-3 ]
  • [ 24484-96-6 ]
Reference: [1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 531 - 538
  • 13
  • [ 99586-65-9 ]
  • [ 24484-96-6 ]
Reference: [1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 531 - 538
  • 14
  • [ 98-98-6 ]
  • [ 24484-96-6 ]
Reference: [1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 531 - 538
  • 15
  • [ 53750-66-6 ]
  • [ 24484-96-6 ]
Reference: [1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 531 - 538
  • 16
  • [ 13091-23-1 ]
  • [ 1681-37-4 ]
  • [ 40497-64-1 ]
  • [ 24484-96-6 ]
Reference: [1] Liebigs Annalen der Chemie, 1991, # 9, p. 875 - 878
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 24484-96-6 ]

Chlorides

Chemical Structure| 22353-35-1

[ 22353-35-1 ]

2-Amino-3-chloro-5-nitropyridine

Similarity: 0.85

Chemical Structure| 1137475-57-0

[ 1137475-57-0 ]

2-Bromo-4-chloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 4487-56-3

[ 4487-56-3 ]

2,4-Dichloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 31872-63-6

[ 31872-63-6 ]

3-Bromo-4-chloro-5-nitropyridine

Similarity: 0.79

Chemical Structure| 65370-42-5

[ 65370-42-5 ]

4-Chloro-2-nitropyridine

Similarity: 0.72

Amines

Chemical Structure| 22353-35-1

[ 22353-35-1 ]

2-Amino-3-chloro-5-nitropyridine

Similarity: 0.85

Chemical Structure| 4214-76-0

[ 4214-76-0 ]

2-Amino-5-nitropyridine

Similarity: 0.77

Chemical Structure| 2586-99-4

[ 2586-99-4 ]

5-Nitropyridine-2,4-diamine

Similarity: 0.72

Chemical Structure| 18344-51-9

[ 18344-51-9 ]

2-Amino-3-methyl-5-nitropyridine

Similarity: 0.72

Chemical Structure| 84487-03-6

[ 84487-03-6 ]

6-Chloro-5-nitropyridin-2-amine

Similarity: 0.71

Nitroes

Chemical Structure| 22353-35-1

[ 22353-35-1 ]

2-Amino-3-chloro-5-nitropyridine

Similarity: 0.85

Chemical Structure| 1137475-57-0

[ 1137475-57-0 ]

2-Bromo-4-chloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 4487-56-3

[ 4487-56-3 ]

2,4-Dichloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 31872-63-6

[ 31872-63-6 ]

3-Bromo-4-chloro-5-nitropyridine

Similarity: 0.79

Chemical Structure| 4214-76-0

[ 4214-76-0 ]

2-Amino-5-nitropyridine

Similarity: 0.77

Related Parent Nucleus of
[ 24484-96-6 ]

Pyridines

Chemical Structure| 22353-35-1

[ 22353-35-1 ]

2-Amino-3-chloro-5-nitropyridine

Similarity: 0.85

Chemical Structure| 1137475-57-0

[ 1137475-57-0 ]

2-Bromo-4-chloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 4487-56-3

[ 4487-56-3 ]

2,4-Dichloro-5-nitropyridine

Similarity: 0.82

Chemical Structure| 31872-63-6

[ 31872-63-6 ]

3-Bromo-4-chloro-5-nitropyridine

Similarity: 0.79

Chemical Structure| 4214-76-0

[ 4214-76-0 ]

2-Amino-5-nitropyridine

Similarity: 0.77