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[ CAS No. 278597-30-1 ] {[proInfo.proName]}

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Chemical Structure| 278597-30-1
Chemical Structure| 278597-30-1
Structure of 278597-30-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 278597-30-1 ]

CAS No. :278597-30-1 MDL No. :MFCD07779212
Formula : C13H13Cl2NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 286.15 Pubchem ID :-
Synonyms :

Safety of [ 278597-30-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 278597-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 278597-30-1 ]

[ 278597-30-1 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 56962-11-9 ]
  • [ 278597-30-1 ]
  • [ 278597-32-3 ]
YieldReaction ConditionsOperation in experiment
63% With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20℃; for 4h; A solution of <strong>[56962-11-9]2-chloro4-hydroxy-benzaldehyde</strong> (0.5 g, 3.2 mmol) and 3-(2,6-dichlorophenyl)4-hydroxymethyl-5-isopropyl-isoxazole (0.9 g, 3.2 mmol) and triphenylphosphine (0.84 g. 3.2 mmol) in dichloromethane (10 mL) was treated with diisopropyl azodicarboxylate (0.63 mL, 3.2 mmol) dropwise. A brief exotherm was observed and the reaction was stirred at ambient temperature 4 hours. The solvent was removed in vacuo and the resulting residue was purified by flash chromatography on silica gel using dichloromethane as the mobile phase. Yield=0.86 g. (63percent) of 3-(2,6-dichlorophenyl)-4-(3'-chloro4'-formylphenoxy)-methyl-5-isopropyl-is oxazole.
  • 2
  • [ 28489-45-4 ]
  • [ 278597-30-1 ]
  • [ 1010107-93-3 ]
YieldReaction ConditionsOperation in experiment
88% With di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 20℃; for 12h; To a suspension of <strong>[28489-45-4]6-methyl-5-nitro-pyridin-2-ol</strong> (0.625 g, 4.1 mmol), [3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-yl]-methanol (1.51g, 5.3mmol) (for preparation refer to: ) and triphenylphosphine (1.91g, 7.4mmol) in benzene (12ml) was added dropwise diisopropyldiazenedicarboxylate (1.57g, 7.8mmol) and the reaction mixture was stirred at room temperature for 12h. The mixture was concentrated under reduced pressure and purified by reversed phase HPLC (column Reprosil-Pur C18-A9, 250*20 mm, gradient elution acetonitrile:water (2:1) - pure acetonitrile) to give 1.53 g (88%) of 6-[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-ylmethoxy]-2-methyl-3-nitro-pyridine as colourless powder.
  • 3
  • [ 21901-41-7 ]
  • [ 278597-30-1 ]
  • 2-[3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-ylmethoxy]-4-methyl-5-nitro-pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 20℃; for 12h; The product derived from step 2 (0.15g, 1.0mmol), [3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-yl]-methanol (0.28g, 1.0mmol) and triphenylphosphine (0.29g, 1.1mmol) in benzene (10 ml) were treated dropwise with diisopropyldiazenedicarboxylate (0.024g, 1.2mmol) and the reaction mixture was stirred at room temperature for 12h. The volatiles were evaporated and the crude material was purified by column chromatography on silica (eluent hexanes:ethyl acetate 3:1) to give 0.15g (56%) of 2-[3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-ylmethoxy]-4-methyl-5-nitro-pyridine
  • 5
  • [ 17609-80-2 ]
  • [ 278597-30-1 ]
  • 2-chloro-4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}aniline [ No CAS ]
YieldReaction ConditionsOperation in experiment
53% With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20℃; for 16h; A mixture of <strong>[17609-80-2]4-amino-3-chlorophenol</strong> (1.14 g, 7.9 MMOL), triphenylphosphine (2.08 g, 7.9 MMOL), [3-(2, 6-DICHLOROPHENYL)-5-ISOPROPYLISOXAZOL-4-YL] METHANOL (2.27 g, 7.9 MMOL) in dichloromethane (20 mL) was treated with DIISOPROPYLAZIDODICARBOXYLATE (1.57 ML, 7.9 MMOL) dropwise. After stirring at ambient temperature for 16h, the material was chromatographed on silica gel eluting with dichloromethane. Yield = 1.73 g (53%) OF 2-CHLORO-4-[3-(2, 6-DICHLOROPHENYL)-5-ISOPROPYLISOXAZOL-4- yl]methoxy}aniline.
  • 6
  • [ 22123-14-4 ]
  • [ 278597-30-1 ]
  • [ 1245613-57-3 ]
  • 7
  • [ 278597-30-1 ]
  • [ 104253-44-3 ]
  • [ 1573119-83-1 ]
  • 8
  • [ 68301-59-7 ]
  • [ 278597-30-1 ]
  • 1-(2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy]phenyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; for 2h; To a solution of l-(2-chloro-4-hydroxyphenyl) ethan- 1-one (150 mg, 0.88 mmol), Compound INT-001 (250 mg, 0.87 mmol) andtriphenylphosphane (346 mg, 1.32 mmol) in tetrahydrofuran (5 mL) was added DIAD (267 mg, 1.32 mmol) dropwise at 0C. The resulting solution was allowed warm to roomtemperature and stirred for another 2 h. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 10). This resulted in 300 mg (78%) of the title compound as a white solid. LC-MS (ESI, m/z):[M+H]+= 438.0, 440.0.
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