CAS No. :	1521-41-1
Formula :	C₉H₁₁NO₃
M.W :	181.19
SMILES Code :	COC1=C(OC)C=C(C=C1)C(N)=O
Synonyms :	3,4-Dimethoxybenzamide
MDL No. :	MFCD00017128
InChI Key :	XNDZRGTVUVVHQT-UHFFFAOYSA-N
Pubchem ID :	73705

Safety of 3,4-Dimethoxybenzamide

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 3,4-Dimethoxybenzamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1521-41-1 ]

[ 1521-41-1 ] Synthesis Path-Downstream 1~54

1
[ 50-00-0 ]
[ 1521-41-1 ]
[ 59630-87-4 ]

References: [1]Acta Chimica Academiae Scientiarum Hungaricae,1955,vol. 6,p. 323,330.

2
[ 91-16-7 ]
[ 463-72-9 ]
[ 1521-41-1 ]

References: [1]Justus Liebigs Annalen der Chemie,1888,vol. 244,p. 72.

3
[ 2024-83-1 ]
[ 1521-41-1 ]

References: [1]Chemical Communications,2013,vol. 49,p. 6060 - 6062.
[2]Catalysis science and technology,2015,vol. 5,p. 1606 - 1622.
[3]Organic Letters,2014,vol. 16,p. 4866 - 4869.
[4]Organic Syntheses,1936,vol. 16,p. 4.
Coll. Vol.,1943,vol. II,p. 44.

4
[ 93-15-2 ]
[ 1521-41-1 ]
[ 109979-90-0 ]

References: [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1952,vol. 72,p. 1537.
Chem.Abstr.,1953,p. 10538.

5
[ 1521-41-1 ]
[ 93-07-2 ]

References: [1]Justus Liebigs Annalen der Chemie,1888,vol. 244,p. 72.
[2]Synthetic Communications,2012,vol. 42,p. 541 - 547.

6
[ 1521-41-1 ]
[ 6315-89-5 ]

References: [1]Organic Syntheses,1936,vol. 16,p. 4.
Coll. Vol.,1943,vol. II,p. 44.

7
[ 60100-09-6 ]
[ 93-07-2 ]
[ 1521-41-1 ]

References: [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1942,vol. 62,p. 532; engl. Ref. S. 169.
Chem.Abstr.,1951,p. 2861.

8
[ 3535-37-3 ]
[ 1521-41-1 ]

References: [1]Monatshefte fur Chemie,1901,vol. 22,p. 418.
Monatshefte fuer Chemie,1906,vol. 27,p. 43.
[2]Organic Letters,2005,vol. 7,p. 4777 - 4779.
[3]Acta Chimica Academiae Scientiarum Hungaricae,1980,vol. 103,p. 259 - 270.
[4]European Journal of Medicinal Chemistry,2009,vol. 44,p. 689 - 700.
[5]Journal of Medicinal Chemistry,2009,vol. 52,p. 3366 - 3376.
[6]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 524 - 527.

9
[ 1521-41-1 ]
[ 6921-34-2 ]
[ 3141-93-3 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 2555,2558.

10
[ 1521-41-1 ]
[ 5763-61-1 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1975,p. 1162 - 1171.

11
[ 1521-41-1 ]
[ 2757-23-5 ]
[ 67048-90-2 ]

References: [1]Journal of Organic Chemistry,1978,vol. 43,p. 3736 - 3742.

12
[ 1521-41-1 ]
[ 2024-83-1 ]

References: [1]Organic Letters,2018,vol. 20,p. 6046 - 6050.
[2]Synthesis,1999,p. 64 - 65.
[3]Chemical Communications,2007,p. 301 - 303.
[4]European Journal of Organic Chemistry,2013,p. 1889 - 1893.
[5]Journal of Organic Chemistry,1999,vol. 64,p. 1713 - 1714.
[6]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2003,vol. 42,p. 3148 - 3151.
[7]Advanced Synthesis and Catalysis,2004,vol. 346,p. 1271 - 1274.
[8]Synthetic Communications,1989,vol. 19,p. 1431 - 1436.

13
[ 1521-41-1 ]
[ 82463-75-0 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1982,p. 1149 - 1152.

14
[ 76195-90-9 ]
[ 1521-41-1 ]
[ 76195-91-0 ]

References: [1]Acta Chimica Academiae Scientiarum Hungaricae,1980,vol. 103,p. 259 - 270.
[2]Acta Chimica Academiae Scientiarum Hungaricae,1980,vol. 103,p. 259 - 270.

15
[ 93-07-2 ]
[ 1521-41-1 ]

References: [1]Organic Letters,2018,vol. 20,p. 6046 - 6050.
[2]Synthesis,2003,p. 272 - 276.
[3]Journal of the Chemical Society. Perkin transactions I,1982,p. 1149 - 1152.
[4]Organic Letters,2005,vol. 7,p. 4777 - 4779.
[5]Monatshefte fur Chemie,1901,vol. 22,p. 418.
Monatshefte fuer Chemie,1906,vol. 27,p. 43.

16
[ 67-56-1 ]
[ 1521-41-1 ]
[ 106107-52-2 ]

References: [1]Journal of Organic Chemistry,1997,vol. 62,p. 7495 - 7496.
[2]Organic Syntheses,2002,vol. 78,p. 234 - 234.
[3]Tetrahedron Letters,2007,vol. 48,p. 531 - 533.

17
2-benzoyl-3-(3,4-dimethoxy-phenyl)-3-oxo-propionic acid ethyl ester [ No CAS ]
ammonium hydroxide [ No CAS ]
[ 1521-41-1 ]
[ 55-21-0 ]
[ 4687-37-0 ]
[ 98-86-2 ]

References: [1]Journal of the Chemical Society,1925,vol. 127,p. 1502.

18
3,4-Dimethoxy-benzaldehyde oxime [ No CAS ]
[ 2024-83-1 ]
[ 1521-41-1 ]
[ 33904-02-8 ]

References: [1]Tetrahedron Letters,2002,vol. 43,p. 2455 - 2457.

19
[ 120-14-9 ]
[ 2024-83-1 ]
[ 1521-41-1 ]
[ 33904-02-8 ]

References: [1]Tetrahedron Letters,2003,vol. 44,p. 7437 - 7439.

20
3,4-Dimethoxy-benzaldehyde oxime [ No CAS ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
92%	With [(eta.(5)-pentamethylcyclopentadienyl)Ir(H2O)3](OTf)2; In water; at 110℃; for 12h;Schlenk technique;	To a stirred solution of 3, 4-dimethoxybenzaldehyde oxime (90.6 mg, 0.5 mmol), [Cp * Ir (H20) 3] [0Tf] 2 (5.1 mg, 0.0075 mmol, %) And water (lml) were added sequentially to a 25 ml Schlenk reaction flask. The reaction mixture was allowed to react at 110 C for 12 hours, then cooled to room temperature. The water was removed by rotary evaporation, and the product was isolated by column chromatography. Yield: 92%. (D, J = 1.9Hz, 2H, ArH), 7.34 (dd, J = 8.3Hz and J = 1.9Hz, 1Hz, ArH). NMR (500MHz, CDC13) , 3.88 (d, J = 8.4Hz, 1 H, ArH), 6.00 (br s, 1 H, N H), 5.88 (br s, 1 H, 13C NMR (125 MHz, CDC13)? 169.2, 152.1, 148.9, 125.8, 120.1, 110.7, 110. 2, 3? 56. 0.
82%	With [(eta.(5)-pentamethylcyclopentadienyl)Ir(H2O)3](OTf)2; water; at 110℃; for 12h;Schlenk technique;	A mixture of 3,4-dimethoxybenzaldehyde oxime(83.1 mg, 0.5 mmol),[Cp * Ir (H2O) 3] [OTf] 2 (10.2 mg, 0.0150 mmol, 3 mol%)And water (1 ml) were sequentially added to a 25 ml Schlenk reaction flask.The reaction mixture was allowed to react at 110 C for 12 hours,Cooled to room temperature,Rotary evaporation to remove water,Column to give the title compound,Yield: 82%.
82.9%	With 732-type strongly acidic cation exchange resin; In toluene; for 0.5h;Reflux;	In a container adding veratraldehyde 1.66g, hydroxylamine hydrochloride 0.95g and water 20 ml, heating to 40 C, stirring 30min; room temperature, for 40% aqueous sodium hydroxide solution to adjust the pH=7, filtering, washing, drying, to obtain the eater aldoxime; added in to the container by the radix of the aldoxime, activation of the 732-type strongly acidic cation exchange resin 30g and toluene 40 ml, heating to reflux, the reaction 0.5h; the temperature to room temperature, filter, recovery ion exchange resin, the filtrate is concentrated; the crude product in ethyl acetate/hexane recrystallization, get the compound goal white solid veratridine amide 1.50g, yield is 82.9%.

References: [1]Catalysis science and technology,2014,vol. 4,p. 988 - 996.
[2]Patent: CN104418682,2016,B .Location in patent: Paragraph 0042-0046.
[3]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2003,vol. 42,p. 3148 - 3151.
[4]Patent: CN104418762,2016,B .Location in patent: Paragraph 0047; 0048; 0049; 0050.
[5]Patent: CN106866448,2017,A .Location in patent: Paragraph 0017.

21
[ 869468-93-9 ]
[ 1521-41-1 ]
[ 128581-33-9 ]

References: [1]Organic Letters,2005,vol. 7,p. 4777 - 4779.

22
[ 1521-41-1 ]
[ 65367-74-0 ]

References: [1]Organic Letters,2005,vol. 7,p. 4777 - 4779.

23
[ 1521-41-1 ]
[ 88720-89-2 ]

References: [1]Organic Letters,2005,vol. 7,p. 4777 - 4779.

24
[ 1521-41-1 ]
[ 101293-65-6 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 2555,2558.

25
[ 1521-41-1 ]
[ 132180-47-3 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 2555,2558.

26
[ 1521-41-1 ]
[ 109867-22-3 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 2555,2558.

27
[ 1521-41-1 ]
[ 67049-06-3 ]

References: [1]Journal of Organic Chemistry,1978,vol. 43,p. 3736 - 3742.

28
[ 1521-41-1 ]
[ 67048-46-8 ]

References: [1]Journal of Organic Chemistry,1978,vol. 43,p. 3736 - 3742.

29
[ 1521-41-1 ]
[ 67113-96-6 ]

References: [1]Journal of Organic Chemistry,1978,vol. 43,p. 3736 - 3742.

30
[ 1521-41-1 ]
[ 67113-95-5 ]

References: [1]Journal of Organic Chemistry,1978,vol. 43,p. 3736 - 3742.

31
[ 1521-41-1 ]
[ 5471-40-9 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1975,p. 1162 - 1171.

32
[ 1521-41-1 ]
[ 50450-21-0 ]
[ 2024-83-1 ]
[ 67-68-5 ]

References: [1]Tetrahedron Letters,2009,vol. 50,p. 5532 - 5535.

33
[ 95-14-7 ]
[ 1521-41-1 ]
[ 630-19-3 ]
[ 1158074-47-5 ]

References: [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 3366 - 3376.

34
3-tosyloxyacetyl-1'-benzenesulfonylindole [ No CAS ]
[ 1521-41-1 ]
[ 1220958-34-8 ]

References: [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 1244 - 1249.

35
[ 120-14-9 ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
75%	With hydroxylamine hydrochloride; C59H50ClN2OP2Ru; sodium hydrogencarbonate; In acetonitrile; for 5h;Inert atmosphere; Reflux;	General procedure: The reaction vessel was equipped with magnetic stirring bar, complex catalyst(1 mol%), aldehyde (1 mmol), NH2OHHCl(1 mmol) and NaHCO3 (1 mmol) was taken and the mixture was placed under an atmosphere of N2. Dry and degassed acetonitrile(3 mL) was added and the reaction mixture was refluxed for 5 h.The reaction mixture was then cooled to room temperature and the solvent was evaporated. The residue was dissolved in CH2Cl2,filtered and the solvent was removed. The amide was then purified using column chromatography, which gives the amide in high isolated yield. The products were confirmed by1H NMR spectra.

References: [1]Bulletin of the Korean Chemical Society,2012,vol. 33,p. 2129 - 2130.
[2]Advanced Synthesis and Catalysis,2010,vol. 352,p. 288 - 292.
[3]European Journal of Organic Chemistry,2011,p. 2226 - 2229.
[4]Journal of Organometallic Chemistry,2020,vol. 923.
[5]Organic Letters,2016,vol. 18,p. 5788 - 5791.
[6]New Journal of Chemistry,2016,vol. 40,p. 1626 - 1632.

36
[ 93-03-8 ]
[ 1521-41-1 ]
1,3-bis-(3,4-dimethoxyphenyl)urea [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2010,vol. 352,p. 2588 - 2598.

37
[ 91-16-7 ]
[ 75-52-5 ]
[ 1521-41-1 ]

References: [1]Synthetic Communications,2012,vol. 42,p. 541 - 547.

38
[ 93-03-8 ]
[ 1521-41-1 ]

References: [1]Catalysis Communications,2012,vol. 26,p. 48 - 53.
[2]Green Chemistry,2013,vol. 15,p. 1956 - 1961.

39
3,4-Dimethoxy-benzaldehyde oxime [ No CAS ]
[ 2024-83-1 ]
[ 1521-41-1 ]

References: [1]Synthetic Communications,2013,vol. 43,p. 1778 - 1786.

40
[ 1521-41-1 ]
[ 501-65-5 ]
[ 1404499-96-2 ]

References: [1]Chemical Communications,2013,vol. 49,p. 6060 - 6062.

41
[ 1521-41-1 ]
[ 1444611-72-6 ]

References: [1]Chemical Communications,2013,vol. 49,p. 6060 - 6062.

42
[ 1521-41-1 ]
[ 1444611-74-8 ]

References: [1]Chemical Communications,2013,vol. 49,p. 6060 - 6062.

43
[ 1131-62-0 ]
[ 1521-41-1 ]

References: [1]Advanced Synthesis and Catalysis,2013,vol. 355,p. 3591 - 3596.
[2]Angewandte Chemie - International Edition,2014,vol. 53,p. 6528 - 6532.
Angew. Chem.,2014,vol. 126,p. 6646 - 6650,5.

44
[ 141-32-2 ]
[ 1521-41-1 ]
butyl (Z)-2-(5,6-dimethoxy-3-oxoisoindolin-1-ylidene)acetate [ No CAS ]

References: [1]Organic Letters,2014,vol. 16,p. 4866 - 4869.

45
[ 5888-51-7 ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
81%	With tert.-butylhydroperoxide; ammonia; iodine; In water; at 100℃; for 3h;Sealed tube; Green chemistry;	General procedure: A sealed tube equipped with a magnetic stirring bar was charged with ethylarene (1, 1.0 mmol), aq NH3 (2, 25% aq solution,10.0 mmol), I2 (1.1 mmol), and TBHP (6.0 mmol, 70% aq solution) at r.t. The resulting mixture was heated to 100 C for 3.0 h. After completion of the reaction (monitored by TLC), sat.Na2S2O3 solution (10 mL) was added to the reaction mixture,and it was extracted with EtOAc (2 × 20 mL). The organic layer was washed with brine solution (20 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on 100-200 mesh silica gel using EtOAc-n-hexane (1:2) as the eluent to obtain the corresponding benzamide 3.

References: [1]Synlett,2015,vol. 26,p. 1677 - 1682.

46
[ 61117-58-6 ]
[ 2859-78-1 ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
87%	With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90℃; for 3h;Sealed tube;	General procedure: To a stirred solution of aryl halide (Br/I) (1 mmol) in dry dioxane in a 25 mL sealed tube, was added Pd(OAc)2 (5 mol%), dppf (6 mol %), DIPEA (2 mmol), imidazole (0.25 mmol), ammonium chloride (2 mmol) and then Co2(CO)8 (0.3 mmol). The seal tube was closed immediately and stirred at 90 C for 3h. After the reaction time the reaction mixture was cooled to room temperature. The reaction mixture was filtered through celite pad and washed with dioxane, the filtrate was concentrated under reduced pressure and the residue obtained was purified by column chromatography.

References: [1]Tetrahedron Letters,2015,vol. 56,p. 4864 - 4867.

47
[ 93-07-2 ]
[ 2024-83-1 ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
67%; 30%	With diisobutylaluminium hydride; ammonium chloride; In tetrahydrofuran; at 66℃; for 16h;Inert atmosphere;	General procedure: The solution of aminoalane reagent (prepared from 20 equiv. DIBAL-H in case of ester and lactonesubstrates or from 40 equiv. in case of carboxylic acid and amide substrates) was added to a solutionof carboxylic acid (1 eqiuv.) or its derivative (lactone, ester or amide, 1 equiv.) in anhydrous THF atroom temperature. Stirring was continued for 16 hours at 66 C. After this time, the reaction mixturewas cooled, quenched with aqueous solution of KHSO4 and the product was extracted with CHCl3.The extract was washed with water, dried over anhydrous sodium sulfate, and the solvent was evaporated. The crude product was purified by silica gel chromatography with hexane / ethyl acetateelution.

References: [1]Synlett,2015,vol. 26,p. 2288 - 2292.

48
[ 3943-77-9 ]
[ 2024-83-1 ]
[ 1521-41-1 ]

Yield	Reaction Conditions	Operation in experiment
77%; 23%	With diisobutylaluminium hydride; ammonium chloride; In tetrahydrofuran; at 66℃; for 16h;Inert atmosphere;	General procedure: The solution of aminoalane reagent (prepared from 20 equiv. DIBAL-H in case of ester and lactonesubstrates or from 40 equiv. in case of carboxylic acid and amide substrates) was added to a solutionof carboxylic acid (1 eqiuv.) or its derivative (lactone, ester or amide, 1 equiv.) in anhydrous THF atroom temperature. Stirring was continued for 16 hours at 66 C. After this time, the reaction mixturewas cooled, quenched with aqueous solution of KHSO4 and the product was extracted with CHCl3.The extract was washed with water, dried over anhydrous sodium sulfate, and the solvent was evaporated. The crude product was purified by silica gel chromatography with hexane / ethyl acetateelution.

References: [1]Synlett,2015,vol. 26,p. 2288 - 2292.

49
[ 494-99-5 ]
[ 1521-41-1 ]

References: [1]Advanced Synthesis and Catalysis,2015,vol. 357,p. 2566 - 2570.

50
[ 4302-52-7 ]
[ 1521-41-1 ]

References: [1]Advanced Synthesis and Catalysis,2016,vol. 358,p. 500 - 505.

51
[ 1521-41-1 ]
[ 120329-58-0 ]
[ 1041381-45-6 ]

References: [1]New Journal of Chemistry,2016,vol. 40,p. 1626 - 1632.

52
[ 127-19-5 ]
[ 1521-41-1 ]
methylene bis(3,4-dimethoxybenzamide) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With sodium persulfate; ammonium cerium (IV) nitrate; In water; at 110℃; for 12h;Schlenk technique; Sealed tube;	In a Schlenk tube charged successively 3,4-dimethoxy benzamide (0.5mmol), sodium persulfate (2mmol), ceric ammonium nitrate (0.025mmol), N, N- dimethylacetamide (2 mmol), 1ml of deionized water was added, the system was then sealed and heated in an oil bath at 110 deg.] C after about 12 hours. after completion of the reaction was cooled and extracted with ethyl acetate (15ml × 3), and concentrated by a simple column chromatography ( eluent petroleum ether: ethyl acetate = 2: 1) to giveMethylene-bis-3,4-dimethoxy-benzamide, the yield was 75%

References: [1]Patent: CN104447391,2016,B .Location in patent: Paragraph 0054; 0055; 0056.

53
[ 1521-41-1 ]
2-(3,4-dimethoxyphenyl)quinolin-4(1H)-one [ No CAS ]

References: [1]Tetrahedron Letters,2017,vol. 58,p. 279 - 284.

54
[ 1521-41-1 ]
2-(3, 4-dimethoxyphenyl)-4-phenoxyquinoline [ No CAS ]

References: [1]Tetrahedron Letters,2017,vol. 58,p. 279 - 284.

Historical Records

Technical Information

• Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Hydrogenolysis of Benzyl Ether • Nomenclature of Ethers • Preparation of Alkylbenzene • Preparation of Ethers • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Vilsmeier-Haack Reaction

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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1521-41-1

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CAS No.: 1521-41-1

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