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CAS No. : | 625-92-3 |
Formula : | C5H3Br2N |
M.W : | 236.89 |
SMILES Code : | BrC1=CN=CC(Br)=C1 |
MDL No. : | MFCD00014634 |
InChI Key : | SOSPMXMEOFGPIM-UHFFFAOYSA-N |
Pubchem ID : | 69369 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110℃; for 16h;Inert atmosphere; | A mixture of 3,5-dibromo-pyridine (20 g, 84 mmol), CuT (4.76 g, 25 mmol), KI (83.7 g,504 mmol) and N,N-dimethyl-ethane-1,2-diamine (4.4 g, 50.4 mmol) in dioxane (400 mL)was stilTed at 110C for 16 hours. The reaction solution was filtered and the filtrate wasconcentrated under reduced pressure to give a crude solid which was washed with EtOAc(100 mL) and DCM (100 mL) to give the title product as a white solid (13 g, 47%). MS:331.5 (M+H). It was used directly in the next step without further purification. | |
With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110℃; for 16h;Inert atmosphere; | A mixture of 3,5-dibromopyridine (20 g, 84 mmol), CuT (4.76 g, 25 mmol), KI (83.7 g,504 mmol) and N?, N2-dimethylethane-1,2-diamine (4.4 g, 50.4 mmol) in dioxane (400 mL) was stirred at 110C for 16 hours. During this time, the reaction progress was monitored by LC/MS. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to afford a solid, which was then washed with EtOAc (100 mL)and DCM (100 mL) to give the crude title compound as a gray solid (13 g, 47%). MS:331.50 (M+Hj. It was used in the next step without further purification. | |
With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110℃; for 16h;Inert atmosphere; | A mixture of 3,5-dibromopyridine (20 g, 84 mmol), CuT (4.76 g, 25 mmol), KI (83.7 g,504 mmol) and N?, N2-dimethylethane-1,2-diamine (4.4 g, 50.4 mmol) in dioxane (400mL) was stirred at 110C for 16 hours. During this time, the reaction progress wasmonitored by LC/MS. The reaction mixture was filtered and the filtrate was concentratedunder reduced pressure to afford a solid, which was then washed with EtOAc (100 mL) and DCM (100 mL) to give the crude title compound as a gray solid (13 g, 47%). MS:331.50 (M+Hj. It was used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20% | tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; ethyl acetate; | Example 123A 4-(5-Bromo-pyridin-3-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester A solution of the 3,5-dibromo-pyridine (12.8 g, 68.8 mmol) and piperazine-1-carboxylic acid tert butyl ester (10 g, 42.4 mmol) in 200 mL of dioxane was treated with Pd2(dba)3 (5 g, 5.5 mmol), 2-(di-tbutyl-phosphino)biphenyl (4 g, 13.4 mmol), and sodium t-butoxide (7.2 g, 75 mmol). The reaction was heated to 95° C. for 8 h then cooled and filtered through celite. The mixture was evaporated and the residue was purified by flash column chromatography on silica gel, eluding with a solvent gradient of 1:4 ethyl acetate/hexane to 100percent ethyl acetate. Recovered 2.9 g of product (20percent). MS (ESI) m/z 344 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With n-butyllithium; oxone; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; | Step 2 3-Bromo-5-Methylsulfonylpyridine To 3,5-dibromopyridine (2.96 g, 12.5 mmol) in diethyl ether (70 ml) at -78 C. was added n-butyllithium 1.6M in hexanes (8.6 ml, 13.7 mmol) and the resulting mixture was stirred in the cold for 3 hours. Dimethyl disulfide (1.12 ml, 12.5 mmol) was added and the mixture was warmed to room temperature, then partitioned between ether and water. To the crude product from evaporation of the organic phase was added tetrahydrofuran (80 ml), methanol (20 ml), oxone (17 g) and enough saturated aqueous sodium bicarbonate to afford a slightly basic medium. After stirring for 4 hours at room temperature, an excess of 1M aqueous sodium metabisulfite was added, the organic solvents were evaporated, and the residue was partitioned between ethyl acetate and water. The crude product from the organic phase was stirred in a small volume of ethyl acetate and filtered to afford the 3-Bromo-5-methylsulfonylpyridine compound as a solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120℃; | EXAMPLE 21 Preparation of (5-Bromopyridin-3-yl)-4-piperidin-1-ylmethylphenyl)amine (73). A vial was charged with palladium acetate (16.8 mg, 5 mol %), (+/-)BINAP (46.7 mg, 5 mol %) and toluene (5 mL). The mixture was stirred and flushed with nitrogen for 10 min. Another round bottom flask was charged with 3,5-dibromopyridine (355.4 mg, 1.5 mmol), amine 72 (342.5 mg, 1.8 mmol) and cesium carbonate (2.44 g, 7.5 mmol). Then the Pd(OAc)2/BINAP solution was added to the flask and the vial was rinsed with additional toluene (5 mL). The resulting mixture was flushed with nitrogen for 5 min and subsequently heated in a preheated oil bath at 120 C. under vigorous stirring overnight. After cooling, the mixture was filtered and the solid was washed with CH2Cl2. The organic layers were combined and evaporated under reduced pressure to give a brown solid. The solid was purified via flash column chromatography, eluding with hexane/EtOAc to give the product as a yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium acetate;palladium diacetate; In tetrahydrofuran; for 5h;Reflux; Inert atmosphere;Product distribution / selectivity; | Example 3; Synthesis of Compound of Formula IV To a flame dried 3-neck round bottom flask fitted with a condenser, a nitrogen inlet, and a rubber septum was added PcyBiPh (84 mg, 0.20 mmol) and Pd(OAc)2 (19.0 mg, 0.080 mmol). The flask was then protected from the atmosphere and was charged with anhydrous THF (10 mL) and the solution was degassed by purging N2 through the stirred solution. After 15 minutes, the reaction mixture was charged with 3,5-dibromopyridine (0.315 g, 1.33 mmol), pinacolate diborane (0.338 g, 2.66 mmol), dry KOAc (0.217 g, 12.2 mmol), and the mixture was heated at reflux for 5 hours. The reaction mixture was cooled to room temperature and charged with the compound 2, (1.60 g, 3.2 mmol), Na2CO3 (1.20 g, 11.3 mmol), Cs2CO3 (1.10 g, 3.38 mmol), and degassed H2O (0.25 mL). The mixture was then heated at reflux for 20 hours, after which it was cooled to room temperature and concentrated to dryness. The crude material thus obtained was suspended in H2O, collected by filtration, and washed with H2O. The dried solid was chromatographed through SiO2 (3-5% MeOH/CH2Cl2) to give compound of formula IV as a colorless solid. Yield: 0.851 g, 64%. 1H NMR (400 MHz, CD3OD/CD2Cl2, 25 C.) delta7.46 (m, 4H), 7.66 (t, 4H), 7.72 (m, 6H), 7.83 (m, 2H), 7.90 (m, 2H), 8.07 (m, 10H), 8.26 (m, 4H), 8.33 (t, 1H), 8.44 (t, 4H), 8.54 (m, 4H), 8.89 (m, 4H), 8.93 (m, 2H). | |
With potassium acetate;palladium diacetate; CyJohnPhos; In tetrahydrofuran; for 5h;Inert atmosphere; Reflux; | EXAMPLE 3: synthesis of compound of formula IV[0040] To a flame dried 3-neck round bottom flask fitted with a condenser, a nitrogen inlet, and a rubber septum was added PcyBiPh (84 ing, 0.20 mmol) and Pd(OAc)2 (19.0 mg, 0.080 mmol). The flask was then protected from the atmosphere and was charged with anhydrous THF (10 mL) and the solution was degassed by- purging N2 through the stirred solution. After 15 minutes,, the reaction mixture was charged with 3.5-dibromopyridine (0.315 g, 1.33 mmol), pinacolate diborane (0.338 g, 2.66 mmol), dry KOAc (0.217 g, 12.2 mmol), and the mixture was heated at refiux for 5 hours. The reaction mixture was cooled to room temperature and charged with the compound 2, (1.60 g, 3.2 mmol), Na3CO3 (1.20 g, 11.3 mmolX Cs2CO3 (1.10 g, 3.38 mmol). and degassed H2O (0.25 mL). The mixture was then heated at refiux for 20 hours, after which it was cooled to room temperature and concentrated to dryness. The crude materia. thus obtained was suspended in H2O. collected by filtration, and washed with H2O. The dried solid was chromatographed through Sitheta2 (3-5% MeOH/CH2Cl2) to give compound of formula IV as a colorless solid. Yield: 0.851 g, 64%. 1H NMR (400 MH/, CD3OD/CD2Cl2, 25 C) 61.46 Cm, 4H), 7.66 (t, 4H), 7.72 (m, 6H), 7.83 (m, 2H), 7.90 (m, 2H), 8.07 (m, 10H), 8.26 (m, 4H), 8.33 (t, 1H), 8.44 (t, 4H), 8.54 (n% 4H), 8.89 (m, 4H), 8.93 (m, 2H). | |
With potassium acetate;palladium diacetate; CyJohnPhos; In 1,4-dioxane; at 110℃; for 3h;Inert atmosphere; | EXAMPLE 9: synthesis of compound of formula XJ0047J To a schlenk tube was charged 3,5-dibromopyridine (50 mg, 0.21 mmol), pinacolate diborane (0.117 g, 0.462 mmol), dry KOAc (0.1 g, 1 mmol), ligandPCvBin (6.7 mgt 0.0 3 mg, 0.03 mmoL 3%). The schlenk tube was evacuated and filled with argon three times. The schlenk was placed in an argon atmosphere. Anhydrous dioxane (6 tnL) was added. The flask was then heated at 1 K) C for 3 hours under argon atmosphere. Then compound 3 (0.25 g, 0.5 mmol), dry KOAc (0,1 g, 1 mmolX, ligand PCyBin (6.7 mg, 0,017 mmol, 4%) and Pd(OAc)Z (3 nig, 0.013 mmol, 3%) and 5 ml dioxane were added into above reaction solution, then reiluxed at 1 10 X overnight under argon atmosphere. Then cooled to ambient temperature. Distilled water (30 mL) was added via a funnel, and the resulting mixture was filtered on a Bchner funnel. The filtrate was transferred to a separatory funnel and extracted with CIhCh O x 30 mL). The combined organic phases were dried over Na^SO4, filtered on filter paper and concentrated to dryness by rotary evaporation (30 C, 25 mmHg). The resulting yellow solid was purified by column chromatography affording as a white solid 94 mg (45%). 1H NMR (400 MHz, CDCI3) delta 8.94 (m, 6H), 8.64 (m, 4H), 8.20 (m, 1H), 7.97-7.91 (m, 16H). 7.82-7.63 (m, 18H), 7.41 (m, 4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64.4% | With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; water; toluene; for 9h;Reflux; | Step 5: Synthesis of Intermediate (G)45.1 g (84 mmol) of the intermediate (F), 20.0 g (84 mmol) of 3,5-dibromopyridine, and 2.44 g (2.1 mmol) of tetrakis-(triphenyl phosphine) palladium were suspended in 600 ml of tetrahydrofuran and 400 ml of toluene, and then the suspension was added with a solution in which 23.3 g (169 mmol) of potassium carbonate was dissolved in 400 ml of water. The obtained mixture was heated and refluxed for 9 hours. The reaction fluid was separated into two layers, and an organic layer thereof was cleaned with a sodium chloride saturated aqueous solution and dried with anhydrous sodium sulfate.The organic solvent was removed by distillation under a reduced pressure, and the residue was recrystallized by toluene. The precipitated crystals were separated by filtration and cleansed with toluene to provide 30.7 g (64.4%) of the intermediate (G). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Step 1 : A solution of THF:toluene (2.1 1 mL:2.11 mL) and -BuLi (0.923 ml, 1.48 mmol) was cooled to -10 C. The reaction mixture was purged/filled with argon (3x). w-Butyl magnesium chloride (0.369 ml, 0.739 mmol) was added to the reaction mixture and stirred for 30 minutes. 3,5-Dibromopyridine (0.5 g, 2.1 11 mmol) was added to the reaction mixture over the course of 30 minutes, keeping bath below -10 C and stirred for 1 hour. Ethyl 3- oxocyclopentanecarboxylate (0.330 g, 2.11 1 mmol) was added to the reaction mixture and stirred at -10 C for ~5 minutes. The reaction mixture was warmed to room temperature, diluted with saturated ammonium, extracted DCM (3x), and combined organic layers were concentrated under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate/hexanes) to afford ethyl 3-(5-bromopyridin-3-yl)-3-hydroxycyclopentanecarboxylate. MS ESI calc'd for Ci3Hi7BrN03 [M + H]+ 314 and 316, found 314 and 316. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
125 mg | To a cooled (?15° C.) solution of 3,5-dibromopyridine (1.2 g, 5.0 mmol) in THF (12 mL) is added a solution of isopropylmagnesium chloride-lithium chloride complex in THF (1.7 M; 2.9 mL, 4.9 mmol). The resultant mixture is stirred at ?15° C. for 30 min and dihydro-furan-3-one (517 mg, 6.0 mmol) is added. After stirring for 16 h, the reaction is quenched with saturated aqueous NH4Cl solution and is extracted with EtOAc. The combined organic extracts are washed with water and brine, dried and concentrated under reduced pressure. Purification by flash column chromatography provides 125 mg of 3-(5-bromo-pyridin-3-yl)-tetrahydro-furan-3-ol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100℃; for 12h;Inert atmosphere; | A solution of Pd2(dba)3 (322 mg, 0.352 mmol) and XantPhos (204 mg, 0.352 mmol) in dioxane (10 mL) was stirred at 50 C for 5 min under N2. Then 3,5-dibromopyridine (1.00 g, 4.20 mmol), <strong>[109-11-5]morpholin-3-one</strong> (356 mg, 0.352 mmol) and Cs2C03 (2.30 g, 7.00 mmol) was added to the solution. The resulting mixture was stirred at 100 C for 12 h under N2. A black brown solid was formed. TLC (EtO Ac/PE = 2: 1) showed starting material was consumed completely and the new point was formed at Rf = 0.28. The reaction mixture was filtered and the filtrate was concentrated. Amounts of crude product were increased using the same procedure. The combined amounts of crude were then purified by combi flash (with 6% EtOAc in pentane) to give 4-(5-bromopyridin-3-yl)<strong>[109-11-5]morpholin-3-one</strong> (510 mg, yield: 51%) as a yellow solid. NMR (400 MHz, CDCb) d 3.81 (2H, t , J = 5.2 Hz), 4.05 (2H, t, J= 5.2 Hz), 4.36 (2H, s), 7.97 (1H, d, J = 2.0 Hz), 8.57 (2H, dd, J = 4.0, 2.0 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 100℃; for 16h;Inert atmosphere; | Step 4: Preparation of 2-(5-bromopyridin-3-yl)-5-methyl-1,2,5-thiadiazolidine 1,1-dioxide. [0771] A mixture of <strong>[67104-97-6]2-methyl-1,2,5-thiadiazolidine 1,1-dioxide</strong> (50 mg, 0.37 mmol), 3, 5- dibromopyridine (261 mg, 1.10 mmol), Cul (21 mg, 0.11 mmol), CS2CO3 (179 mg, 0.550 mmol) and DMEDA (19 mg, 0.22 mmol) in anhydrous dioxane (4 mL) was degassed and purged with N2 for 3 times. Then the resulting reaction mixture was heated at 100 C for 16 hours under N2 atmosphere. The reaction mixture turned into blue suspension from yellow. LCMS showed the purity of the desired product is 31% (Rt = 0.692 min; MS Calcd: 291.0; MS Found: 291.6 [M+H]+). The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by Combi Flash (20% to 60% EtOAc in PE) to give 2-(5- bromopyridin-3-yl)-5-methyl-1,2,5-thiadiazolidine 1,1-dioxide (58 mg, yield: 54%) as a white solid. NMR (400 MHz, CDCb) d 2.88 (3H, s), 3.53-3.58 (2H, m), 3.87 (2H, t, J= 6.4 Hz), 7.81 (1H, t, J= 2.4 Hz), 8.39 (1H, d, J= 2.4 Hz), 8.46 (1H, d, J= 2.0 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 110℃; | In a 100 ml three-necked flask, 3,5-dibromopyridine and <strong>[133730-34-4]2,4-dimethoxyphenylboronic acid</strong> were added thereto in a molar ratio of 1: 2, and then anhydrous sodium carbonate and the catalyst 10% mol of [1,1'-bis (Diphenylphosphino) ferrocene]palladium dichloride, using 1,4-dioxane and water in a volume ratio of 4: 1 as a solvent, refluxing at 110 C in an oil bath overnight, the reaction is complete The solvent was evaporated, extracted with water and dichloromethane, dried over anhydrous sodium sulfate, and the mixture was separated through a silica gel column to obtain 3,5-bis (2,4-dimethoxyphenyl) pyridine as a white solid with a yield of 78%. |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 110℃; | In a 100 mL three-necked flask, 2.4 g of 3, 5-dibromopyridine (CAS: 625-92-3) and 3.6 g of 2, 4-dimethoxyphenylboronic acid were added to the beaker at a molar ratio of 1: 2. Then add 2.1g of anhydrous sodium carbonate and 0.4g of tetratriphenylphosphine palladium, use 1,4-dioxane 80 mL and 20 mL of water as solvents, and heat to reflux at 110 C in an oil bath overnight. The solvent was evaporated, extracted with water and dichloromethane, dried over anhydrous sodium sulfate, and the organic phase was separated. The obtained organic phase was concentrated and purified by column chromatography to obtain bis (2,4-dimethoxyphenyl) pyridine as a white solid. |
Tags: 3,5-Dibromopyridine | Pyridines | Bromides | Organic Building Blocks | Heterocyclic Building Blocks | 625-92-3
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P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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