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Chemical Structure| 109-00-2 Chemical Structure| 109-00-2
Chemical Structure| 109-00-2

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Product Citations

Yan, Kaili ; Kwon, Hyuna ; Huddleston, Morgan ; Jiang, De-en ; Sun, Yujie ;

Abstract: Electrocatalytic biomass valorization has attracted increasing interest over the years. Amongst many possible products from biomass upgrading, pyridine-containing chems. are rarely reported. Herein, we describe an electrochem. synthesis of 3-pyridniol from biomass-derived furfurylamine in 0.1 M H2SO4, taking advantage of the Br-/Br+ redox cycle and the strong acidic condition in driving the final dehydration step. Such an electrosynthesis approach was able to achieve a 97% yield of 3-pyridinol from the nearly complete conversion of furfurylamine. A number of control experiments aided by computational investigation were carried out to elucidate the key mechanistic steps of the ''one-pot'' conversion of furfurylamine to 3-pyridinol.

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Product Details of 3-Hydroxypyridine

CAS No. :109-00-2
Formula : C5H5NO
M.W : 95.10
SMILES Code : OC1=CC=CN=C1
MDL No. :MFCD00006378
InChI Key :GRFNBEZIAWKNCO-UHFFFAOYSA-N
Pubchem ID :7971

Safety of 3-Hydroxypyridine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-Hydroxypyridine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 109-00-2 ]
  • Downstream synthetic route of [ 109-00-2 ]

[ 109-00-2 ] Synthesis Path-Upstream   1~3

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  • [ 109-00-2 ]
  • [ 80650-45-9 ]
References: [1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5473 - 5476.
[2] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1253 - 1256.
[3] Patent: WO2014/176258, 2014, A1, .
[4] Organic Letters, 2015, vol. 17, # 3, p. 426 - 429.
[5] Chemical Communications, 2017, vol. 53, # 95, p. 12814 - 12817.
[6] Patent: WO2009/117421, 2009, A2, .
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  • [ 109-00-2 ]
  • [ 350-46-9 ]
  • [ 80650-45-9 ]
References: [1] Patent: US9138427, 2015, B2, .
  • 3
  • [ 109-00-2 ]
  • [ 76066-07-4 ]
References: [1] Tetrahedron, 1986, vol. 42, # 5, p. 1475 - 1485.
 

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